Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0740441 (acute diarrhea)
 2,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Group A rotavirus was identified in 51 of 245 (20.8%) cases with acute diarrhoea in Chennai analysed between December 1997 and March 1999. Forty eight of the 51 specimens were subgrouped and serotyped. A total of 110 rotavirus positive specimens (inclusive of 62 rotavirus positive cases reported earlier) were analysed for their subgroup (SG) specificity and genomic profiles. SGI and SGII specificity were detected in 60 per cent and 20 per cent of the cases studied. Twenty two cases showed dual SG specificity (SGI + II). Nine electropherotypic patterns (7 'short' and 2 'long') were observed with a predominance of short pattern in 87 of the 110 (79.1%) positive cases studied. Long electropherotypes were found in 23 (20.9%). Serotyping of the 48 rotavirus positives revealed a higher proportion of serotype-2 (68.8%) followed by serotype-1 (14.6%) and serotype-3 in 1 case. Mixed infection of G1-G2 was observed among 7 cases analysed, which revealed G[2,1], P[4,8] genotype specificity. Dual infection of P[4]-P[8] genotypes was observed in 12 cases with G[2] specificity.
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PMID:Genomic diversity of group A rotavirus RNA from children with acute diarrhoea in Chennai, south India. 1082 67

Giardiasis is the most worldwide parasitic disease with the major clinical impact on infant and children. Two genotypes were reported commonly among humans (assemblage A and B). In this study, genotypes of Giardia intestinalis clinical isolates obtaining from 24 gastrointestinal symptomatic Saudi primary school children and 16 asymptomatic ones were explored by real-time polymerase chain reaction using the high resolution melting curve analysis targeting intergenic spacer (IGS) region rDNA of G. intestinalis. Children having acute, intermittent, and chronic diarrhea were 14, 5, and 5, respectively. Among all the giardiasis subjects, assemblage B was 37.5% followed by both of assemblages AI and AII with 30% and 27.5%, respectively. Mixed infection with the three previous assemblages was present in 5% of cases. Among symptomatic children, the prevalence of assemblage B was 62.5% then followed by assemblage AI (16.7%) and assemblage AII with 12.5%. All of the children who harbored G. intestinalis assemblages B were symptomatic, while asymptomatic ones had only assemblage AI and AII with 50% each. The difference was statistically highly significant. In symptomatic patients having acute diarrhea, assemblage B was present in 71.5%, while assemblage AI and AII were equal with 7.1%. All of the patients (14.3%) with mixed infection had acute diarrhea. In intermittent diarrhea, assemblage AI and B were equally distributed with 40% each. In chronic diarrhea, assemblage AI and AII were equal with 20% each, while assemblage B was found in 60%. The difference was statistically not significant. In conclusion, assemblage B is the commonest, while assemblage A is a predominant in symptomatic and asymptomatic giardiasis Saudi children, respectively. So human transmission is the common risk factor among symptomatic, while zoonotic transmission is a common risk factor in asymptomatic ones. On the other hand, a strong correlation between assemblage B and symptoms and no relation between genotypes and types of diarrhea are found. Also, PCR with HRM in one-step closed-tube methods is able to genotype G. intestinalis IGS rDNA without using the sequencing methods or the electrophoresis.
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PMID:Genotypes of Giardia intestinalis clinical isolates of gastrointestinal symptomatic and asymptomatic Saudi children. 2083 11

Objective: To explore pathogen spectrum constitution of acute diarrhea in outpatient and emergency of Zhejiang Province, and provide basis for treatment, prevention and control of the disease. Methods: During January 2009 to December 2014, we selected seven sentinel hospitals in different regions of Zhejiang, monitored and researched on pathogen spectrum in patients with acute diarrhea from outpatient and emergency. We recorded patients' personal basic information, the main symptoms and signs, and collected stool samples (5 g). Eight kinds of bacteria (Vibrio cholerae, Shigella spp., Salmonella spp., Diarrheagenic E. coli, Vibrio parahaemolyticus, Aeromonas hydrophila, Yersinia enterocolitica and Plesiomonas shigelloides) and five kinds of viruses (Rotavirus, Norovirus, Sappovirus, Astrovirus and Adenovirus) were detected. Chi-square test and Fisher's exact probability method were used to compare different characteristics of patients with single bacterial infection, single virus infection and multiple infection (bacteria-bacteria, bacteria-viruses, virus-virus). Results: During 2009 to 2014, 9 364 fecal samples from acute diarrhea patients were collected and tested, among which 3 500 cases were tested positive, with total positive rate of 37.38%. Positive rates of bacteria and viruses were 13.14% (1 230 cases) and 20.75% (1 943 cases), respectively. Mixed infection positive rate of multiple pathogens was 3.49% (327 cases). Positive rate of Vibrio parahaemolyticus (5.96% , 558 cases) was the highest among bacterial pathogens, followed by pathogenic Escherichia coli (3.86%, 361 cases). Viruses were mainly Norovirus (10.73%, 1 005 cases) and rotavirus (8.35%, 782 cases). A big difference existed in diarrheogenic pathogen spectrum between patients less than 15 years old and patients equal or older than 15 years old. Pathogens for patients less than 15 years old were mainly virus, with the positive rate of 32.69% (1 014 cases). However, the positive rate of bacteria was 16.86% (1 056 cases) in patients equal or older than 15 years old. Single bacterial infection was highest in age group of 25-34 years old (18.62%, 302 cases) , single virus infection was highest in age group of 1-4 years old (41.12%, 435 cases) , and mixed infections of multiple pathogens were mainly existed in age group of 1-4 years old (7.37%, 78 cases) . Pathogen positive rate were increasing year by year. Pathogen positive rate of patients with acute diarrhea has obvious seasonality, with single bacterial infection being highest during July to September and single virus infection being highest during December to March. Pathogen spectrum of outpatient and emergency patients with acute diarrhea in Zhejiang Province changed a little from 2009 to 2014, mainly rotavirus (22.34% (782/3 500)), norovirus (28.71% (1 005/3 500)), vibrio parahaemolyticus (15.92% (558/3 500)) and Escherichia coli (10.31% (361/3 500)). However, pathogen spectrums in different years owned different features. Conclusion: Common pathogens in outpatient and emergency patients with acute diarrhea in Zhejiang Province were tested with significant seasonal epidemic law. The composition of pathogenic spectrum was variant in different age group. Constitutes of major pathogen spectrum in different years differed a little.
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PMID:[Monitoring and research on pathogen spectrum in patients with acute diarrhea from sentinel hospital of Zhejiang Province during 2009 to 2014]. 2805 13