Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0740441 (acute diarrhea)
 2,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute diarrhea is a major killer of children in the developing world. Underlying malnutrition and occurrence of complications of illness explain the high fatality rate. Oral rehydration prevents death associated with dehydration. Persistent and invasive diarrhea remains an important cause of death. Control of diarrhea through cost-effective public health measures is needed.
 ...
PMID:Diarrheal diseases in the developing world. 767 69

A prospective, placebo-controlled, triple blind clinical trial was carried out in Pakistan to determine the effect of Lactobacillus GG on the course of acute diarrhea in hospitalized children. Forty children (mean age, 13 months) were enrolled and after rehydration received either oral Lactobacillus GG (n = 21) or placebo (n = 19) twice daily for 2 days, in addition to the usual diet. The clinical course of diarrhea was followed during the treatment period. Features on admission into the study groups were similar and were characterized by severe diarrhea, malnutrition and inappropriate management before presentation. Response was evident on Day 2 when the frequency of both vomiting and diarrhea was less in the Lactobacillus group. In those who had presented with acute nonbloody diarrhea (n = 32), the percentage of children with persistent watery diarrhea at 48 hours was significantly less in the Lactobacillus group: 31% vs. 75% (P < 0.01). No significant difference was observed by 48 hours in those presenting with bloody diarrhea. The relevance of this finding to the management of diarrhea in the tropics is discussed.
 ...
PMID:Lactobacillus GG promotes recovery from acute nonbloody diarrhea in Pakistan. 774 91

Cryptosporidium oocysts were detected microscopically in the concentrated faecal smears (stained by modified kinyoun's acid fast stain) in 13 out of 100 (13 per cent) cases of acute diarrhoea (AD < 2 weeks duration), 7 out of 50 (14 per cent) cases of chronic diarrhoea (CD > 2 weeks duration) and none in 50 age matched controls. The grades of malnutrition of the cases and controls were calculated by the weight for age criteria and the immune status assessed by the levels of serum immunoglobulins and SIgA in duodenal fluids. Malnutrition was observed in 6 out of 13 cases (46.1 per cent) in acute and 6 out of 7 cases (85.71 per cent) in chronic cryptosporidial diarrhoeas. There was no significant statistical difference (P > 0.05) in serum immunoglobulins and SIgA levels in chronic cryptosporidiosis. SIgA was significantly reduced (P > 0.05) in cases of acute cryptosporidiosis. Cryptosporidium is an important cause of symptomatic infection in apparently immunocompetent children not having been detected in a single non-diarrhoeal control. Further a low SIgA could contribute to acute symptomatic cryptosporidiosis by favouring colonization with the parasite.
 ...
PMID:Assessment of the immune and nutritional status of the host in childhood diarrhoea due to cryptosporidium. 775 98

Clinical and laboratory studies on a total of 211 of infants and young children admitted to the National Santa Cruz General Hospital for various types of diarrhoea during 1991-1992 are described. A peak cluster was observed in children aged 1 year of which 80 per cent were acute diarrhoea and the remaining 20 per cent were prolonged or chronic diarrhoea. The major bacterial pathogen was enteropathogenic Escherichia coli. Other bacterial pathogens such as Klebsiella, Shigella, Cholera, etc., were detected. Ascaris, E. histolytica, Giardia and Ankylostoma were also detected. Many of the patients infected with enteropathogenic E. coli showed elevated serum titre to these bacterial antigens. Most of the detected E. coli and Shigella revealed that they were resistant to ampicillin, trimethoprim/sulfamethoxazole, and erythromycin, and some were resistant to gentamycin and chloramphenicol in vitro tests. It was difficult to make a diagnosis by clinical diagnosis alone for cholera of the el Tor Ogawa type. The detection of faecal leukocytes seems to be an useful predictor for diagnosis of invasive diarrhoea with mucobloody stools. Faecal pH and erythrocytes did not seem to be reliable diagnostic predictors. Fourteen cases (7 per cent) died of diarrhoeal disease. Many of them had complications with marked dehydration, hypoelectrolytaemia, malnutrition and infections, and rapid deterioration within 10 days despite rehydration therapy. Timely rapid rehydration and restoration of electrolytes followed by suitable management of complications are necessary.
 ...
PMID:Clinical evaluation and bacterial survey in infants and young children with diarrhoea in the Santa Cruz district, Bolivia. 785 44

Ninety-five children between 9 months and 3 years (mean age 14.4 months) with acute diarrhoea were enrolled by simple random sampling and studied for the presence of xerophthalmia and subclinical vitamin-A deficiency (detected by ocular impression cytology). The objective of the study was to estimate the prevalence of vitamin-A deficiency in these children and to evaluate its role as a risk factor for acute diarrhoea. The results were compared with 96 sex-and age-matched (mean age 15.79 months) controls belonging to similar nutritional grades and socioeconomic status who did not have diarrhoea and attended the hospital for treatment of minor ailments or for immunizations. Clinically evident xerophthalmia was observed in 12.6% of cases with acute diarrhoea and in 10.4% of controls. Ocular impression cytology suggested vitamin-A deficiency in 48.4% of cases and 40.6% of controls. However, on comparing the study group with the controls, there was no significant difference in vitamin-A deficiency in the 2 groups on clinical examination (p > 0.05) or by ocular impression cytology (p > 0.05). The prevalence rate of vitamin-A deficiency increased with the severity of malnutrition in cases (p < 0.05) as well as in controls (p < 0.05), but subclinical vitamin-A deficiency was detected even in well-nourished cases (35%) and controls (22.7%). Our results suggest a high prevalence of vitamin-A deficiency in young children from our study population with or without diarrhoea and even in well-nourished children. The association of vitamin-A deficiency was not significantly different in cases of acute diarrhoea than in the controls.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Vitamin A deficiency in children with acute diarrhoea. 796 42

Gastroenteritis in children is usually treated with the graded introduction of milk feeds after rehydration. Although having never been rigorously tested, the practice of gradually increasing milk strength over several days has been considered an appropriate means of warding against lactose intolerance and preventing sensitization to cow's milk antigens. These guidelines were formulated in Europe and North America and invariably lead to a reduction in nutrient intake. Malnourished children in developing countries, however, may experience an average 5-6 episodes of acute diarrhea per year and the nutrient effects are cumulative. A recent study from Latin America explored whether continued feeding is safe for infants under age 6 months and whether malnourished children respond adversely. Infants randomly assigned to receive full strength cow's milk immediately after rehydration did not have more treatment failures, higher stool outputs, or longer lasting diarrhea than those whose feeds were regarded to full strength over 48 hours. It is unclear, however, whether the youngest or more malnourished subjects were overrepresented in the treatment failures. Results also indicate that deciding to change treatment should not be dictated by the presence of reducing substances in the faeces; the majority of infants with reducing substances in their stools did well. This study offers the first scientific support for rapidly reintroducing full-strength milk formula after gastroenteritis is malnourished patients under 6 months of age. The 10% of infants in which dehydration recurs after reintroducing milk feeds are still difficult to manage. In the absence of yogurt or lactose-free formula, a locally-produced modular feed of chicken, starch, and vegetable oil may be suitable.
 ...
PMID:Dietary management of acute diarrhoea in childhood. 809 51

In individual children in developed countries it is possible to follow a sequence of infection of the gastrointestinal tract leading to chronic diarrhoea which, if it long persists, may in turn lead to undernutrition. Both in individuals and epidemiologically in developing countries it is, by contrast, often difficult to be certain whether infection precedes under-nutrition or vice versa. Chronic diarrhoea is heterogeneous and aetiology varies from community to community. Unlike acute diarrhoea, for which there is highly effective unitary therapy (oral rehydration therapy), diverse therapies are required for chronic diarrhoea based on specific diagnoses and so render community strategies difficult. The importance of adequate calorie intake is emphasized but when there is intolerance to food ingested this is counter-productive. The relative importance of post-infective food intolerance remains controversial and in many communities is unknown. Increasing emphasis is now given to the role of infection in pathogenesis of diarrhoea and malnutrition, e.g. the acquired immune deficiency syndrome and Helicobacter pylori. Hospital-based case studies including small intestinal biopsy in individual communities, by virtue of an 'iceberg effect', may prove useful for insights into aetiology and pave the way for interventions, e.g. antibiotics or dietary therapy.
 ...
PMID:Diarrhoeal disease: current concepts and future challenges. Malnutrition and infection. 810 42

To examine the relationship between acute diarrhea and vitamin A status, a study was conducted in 137 children (72 with diarrhea and 65 illness-free control subjects) in the city of Lima, Peru. Serum retinol was measured spectrophotometrically in samples collected in 1987 and kept frozen until they were analyzed simultaneously in 1989. Serum retinol was significantly lower in the children with diarrhea (mean +/- SD: 0.51 +/- 0.48 mumol/L) than in those without diarrhea (1.00 +/- 0.32 mumol/L; 1 mumol/L retinol = 28.6 micrograms/dL). The multivariate estimate of the effect of diarrhea (-0.464 mumol/L) in a model that incorporated age, sex, and acute malnutrition (ie, weight-for-height) as confounding variables was essentially the same as the unadjusted difference (-0.492 mumol/L). Thus, this model showed that the retinol concentration in the serum depends greatly on the presence of diarrhea. These findings suggest that diarrhea, as has been shown for other infections, may lead to lower circulating retinol concentrations and perhaps to its depletion.
 ...
PMID:Association of diarrhea and low serum retinol in Peruvian children. 831 81

In vitro uptake of 14C-labelled amino acids by segments of small intestine was determined in sucking (2-4-d-old) Wistar rats. Intragastric injections of heat-stable (ST) toxin of enterotoxigenic Escherichia coli (ETEC) were given to produce fluid accumulation, defined as a gut weight: carcass weight value of > 0.085. Continued active uptake of the prototypic amino acids, leucine (by active transport system 1 for monoamino monocarboxylic (neutral) amino acids), lysine (by active transport system 2 for dibasic amino acids), and proline (by active transport system 3 for N-substituted amino acids), persisted during the active fluid accumulation response to ETEC ST toxin. The mean Kt and mean Vmax of the amino acid transport systems were similar in control (non-injected) and ST toxin-injected rats. The present study provides a scientific basis for the use of amino acids in oral rehydration solutions utilizing amino acid transport systems which are linked to absorption of Na (and water) so that reduction in diarrhoeal stools can be achieved, and emphasizes the importance of maintaining feeding during acute diarrhoea to prevent development of malnutrition.
 ...
PMID:The effect of Escherichia coli heat-stable (STA) enterotoxin on in vitro uptake of amino acids by small intestine of sucking rats during fluid accumulation. 832 51

A case control study was done at the Institute of Child Health, Madras, among prospectively recruited children aged 1-23 months to identify the risk factors for persistent diarrhea. Cases were children with diarrhea persisting for > 14 days. Controls were children with acute diarrhea who had recovered within 7 days. Two controls for each case, matched for age were recruited. The total number of cases and controls recruited were 170 and 340. Fifteen risk factors for association with persistent diarrhea were studied. When the factors were adjusted for covariables by logistic regression, only 6 factors were found to be significant, namely, malnutrition (OR 2.9; 95% CI 1.9-4.5), dysenteric stools (OR 2.4; 95% CI 1.3-4.3), indiscriminate use of antimicrobials (OR 2.4; 95% CI 1.6-3.9), associated illnesses (OR 2.1; 95% CI 1.5-3.1), stools > 10/day (OR 1.8; 95% CI 1.2-2.8) and persistence of dehydration (OR 1.4; 95% CI 1.2-1.7). However, when invasive diarrhea was excluded, weight loss during study period became a significant factor. It is concluded that all children with acute diarrhea should be investigated for associated illnesses and treated adequately, indiscriminate use of antimicrobials should be avoided and nutritional support should be provided.
 ...
PMID:Risk factors for persistent diarrhea among children under 2 years of age. Case control study. 837 79


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>