Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0740441 (acute diarrhea)
 2,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The efficacy of cholestyramine in acute infantile diarrhea was evaluated in 2 placebo-controlled, randomized, double-blind trials at the Tampere University Central Hospital. In the 1st, cholestyramine, 2 g. 4 times daily, or an equivalent amount of placebo were given, in addition to fluid replacement therapy to 52 infants hospitalized for acute non bacterial diarrhea. The mean duration of watery diarrhea was 2.6 +or- 1.4 days in the placeob group, which was considerably the mean of 0.8 +or- 0.7 days in the cholestryramine group (p 0.001). Cholestyramine treated infants also shwed a better tendency to gain weight. In the 2nd trial, 40 infants with acute diarrhea of less the 24 hours duration were treated as out-patients with cholestyramine (n=15) 2 g. twice daily for 3 days, or with a placebo (n=25), in addition to oral fluids and rapid return to full feedings. The watery diarrhea mean duration in infants receiving cholestyramine was 0.9 +or- 1.1 days, which was significantly the 2.9 +or- 1.5 days in the placebo group (p 0.001). Weight gain was similar in both groups. Cholestyramine therapy was not associated with acidosis or hyperchloremia. It was concluded that 2 g. cholestyramine twice daily is effective in infants in shortening the course of watery diarrhea of rotavirus of nonspecific origin.
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PMID:Efficacy of cholestyramine in acute infantile diarrhoea: placebo-controlled double-blind trial in hospitalized children and in outpatients. 639 3

Acquired vesico-rectal fistula is an uncommon complication of pelvic malignant tumors, surgical injury, inflammatory disorders such as tuberculosis infection, radiotherapy and less commonly diverticulum of the urinary tract. The fistula is often identified by urinary tract abnormalities such as dysuria, recurrent urinary tract infection, pneumaturia, and fecaluria. Here, we report an unusual case of a patient with a vesico-rectal fistula of tuberculous origin, presenting with severe acute diarrhea, metabolic acidosis, hyperchloremia and hypokalemia while with only mild urinary tract symptoms. The patient was cured by tuberculostatic therapy.
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PMID:Acute diarrhea and metabolic acidosis caused by tuberculous vesico-rectal fistula. 2538 96