Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0740441 (acute diarrhea)
 2,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The efficacy of 200mg oral ofloxacin given twice daily for 3 days was evaluated in 98 hospitalized cases with acute diarrhea or dysentery. Sixty cases were female, most of whom were laborers.Vibrio cholerae, Vibrio parahaemolyticus, Shigella flexneri, Shigella boydii, Shigella sonnei, Aeromonas hydrophila, Aeromonas spp., and Plesiomonas shigelloides were isolated from fecal samples in 36 of 86 cases (42%) with diarrhea and 5 of 12 cases (46%) with dysentery.E. coli agglutinated with various E. coli polyvalent antisera were found in another 25 cases (26%). With the exception of E. coli, most of the clinical isolates were highly susceptible to ofloxacin and norfloxacin with minimal inhibitory concentrations (MIC90) of 0.047-0.38 and 0.016-0.25mg/L, respectively. A total cure was achieved in 96.5% of cases with diarrhea and in 100% of cases with dysentery. There was a delayed response in two cases and only one case clinically failed to respond.V. cholerae was repeatedly isolated on day 3 in another case who had recovered on day 2, and 1 case developed gangrenous cholecystitis and ischemic enteropathy after an initial response to ofloxacin.
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PMID:Therapeutic Efficacy of Oral Ofloxacin in Acute Diarrhea and Dysentery. 2968 53

Protein losing enteropathy (PLE), a very rare disease with hypoproteinemia and edema as its characteristics, is caused by various diseases resulting in protein depletion from the gut. The diagnosis is relatively difficult due to its complex pathogeneses. The present paper reported a case whose symptom started with acute diarrhea and hypoproteinemia. Gastrointestinal endoscopies showed digestive ulcers and colon polyp. The treatments contained albumin infusion, Chinese herbal decoction and other symptomatic therapies. The hypoproteinemia become even worse and edema occurred after 4 days' treatment. A larger dose of albumin infusion (40-60 g/d) and modified herbal decoctions were prescribed. A final diagnosis of eosinophilic gastroenteritis (EG) complicated with PLE was confirmed by histopathological examination of a repeated gastroscopy. After three weeks' treatment, the serum albumin level was raised and the edema subsided gradually. In conclusion, herbs may have an effect on PLE patients, but PLE resulting from EG is very complex and easy to misdiagnose, especially in atypical conditions. Further studies are required to find the exact mechanisms.
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PMID:Protein losing enteropathy caused by eosinophilic gastroenteritis: A case report. 3218 44


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