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Query: UMLS:C0740441 (acute diarrhea)
 2,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Studies aimed at improving treatment strategies for patients with acute diarrhea have included the clinical testing of modifications to the standard oral rehydration solution. A malabsorbed carbohydrate has been found to improve resuscitation, probably through the recruitment of colonic absorptive capacity. A reduced osmolarity solution is safe in adults and as effective as the standard solution. For non-nursing infants, increasing the frequency of feeding with reduced volume results in comparable total caloric intake and diminishes the risk of prolonged diarrhea. Increasing resistance of important enteric pathogens to inexpensive and newer antibiotics continues to be a concern. Reports from Asia of decreased Salmonella typhi resistance to chloramphenicol, attributed to restricted antibiotic usage, may indicate a reversal of the usual trend. A strategy to block the action of shiga toxins in the gut through the use of recombinant bacteria has shown promise in a mouse model. A small but well-designed study supported the use of either norfloxacin or amoxicillin-clavulanic acid in the treatment of small bowel overgrowth syndrome. Studies exploring passive immunity strategies for the treatment of Escherichia coli, Cryptosporidium, and Candida infections have reported variable levels of success.
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PMID:Treatment of gastrointestinal infections. 1703 Nov 49

Severe congenital neutropenia (SCN) is a rareE primary immunodeficiency disorder characterized by early onset recurrent infections in association with persistent severe agranulocytosis. To identify the clinical, immunohematological, and molecular characteristics of patients with SCN, 18 Iranian patients with the mean age of 8.8 +/- 5.8 years were investigated in this study. All of these patients experienced severe neutropenia; the mean of absolute neutrophil count was 281.4 +/- 137.7 cells/mm3. Bone marrow findings were typified by a myeloid maturation arrest at the promyelocyte-myelocyte stage in these patients. Molecular analysis revealed different mutations in the ELA-2 gene of one patient and in the HAX-1 gene of another three patients. The most common presenting complaints in these patients were superficial abscesses, oral ulcers, cutaneous infections, omphalitis, and pneumonia. During the course of illness, all patients developed mucocutaneous manifestations, and 16 cases had respiratory infections. The most commonly manifestations were abscesses, oral ulcers, pneumonia, periodontitis, otitis media, cutaneous infections, mucocutaneous candidiasis, and acute diarrhea. Three patients died because of a severe infection. Although SCN is a rare disorder, early onset of severe and recurrent infections should always raise a suspicion, which deserves further evaluation for detecting such disorder.
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PMID:The clinical, immunohematological, and molecular study of Iranian patients with severe congenital neutropenia. 1758 55