Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0730345 (microalbuminuria)
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Human Gene/Protein
chloride intracellular channel 5A 12.0
uromodulin precursor 12.0
TMEM60 11.4
NRBP1 11.4
DOK6 11.0
SCAF8 10.4
Cardiotrophin 1 10.4
FEEL-2 10.4
RPH3A 10.4
CNKSR3 10.1
ZO3 10.1
MEGF1 10.0
GSTK1-1 9.8
FNDC1 9.4
IER3IP1 9.3
adenylate cyclase 6 9.1
Chitinase-3-like protein 1 9.1
heparan sulfate proteoglycan core protein 9.0
SPRC 9.0
PIP5K1B 9.0
FEEL-1 9.0
TFDP2 9.0
GABRR1 8.9
organic anion transporter 5 8.9
IDDM 8.8
SLC6A13 8.8
CUBN 8.7
annexin A9 8.6
B2 microglobulin 8.6
YKT6 8.6
BCAS3 8.5
REG1A 8.4
NIDDM 8.4
protein kinase C substrate 80K-H 8.4
CHN1 8.4
OATP4C1 8.1
Angiotensin II receptor 8.0
CLIC5 8.0
NDST2 7.9
XAGE-1b 7.9
albumin 7.8
LVM 7.8
Dipeptidyl-peptidase IV 7.8
ubiquitin D 7.7
angiotensin II receptor 7.7
GFR 7.6
matrix metalloproteinase 10 7.6
N-acetyl-beta-D-glucosaminidase 7.5
MBOAT7 7.5
Peroxisome proliferator activated receptor gamma 7.5
putative G-protein 7.4
hedgehog interacting protein 7.4
Albumin 7.4
angiotensin receptor 7.3
calpain 10 7.3
N-acetyl-beta-glucosaminidase 7.2
HLA-A2 antigen 7.2
endothelial cell-selective adhesion molecule 7.2
Alb 7.2
haptoglobin-related protein 7.2
CALM 7.2
ACE 7.1
AMBP 7.1
enhancer of zeste 2 7.1
Nephrin 7.1
VDB 7.0
fibrinogen alpha chain 7.0
Retinol-binding protein 4 7.0
Apo(a) 6.9
cubilin 6.9
beta-2-microglobulin 6.8
GIR 6.8
kidney injury molecule 1 6.8
podocalyxin 6.8
podocin 6.8
apolipoprotein A-V 6.8
NAG 6.7
LAMB2 6.7
HSPG 6.7
cystatin C 6.6
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Disease
Nodular diabetic glomerulosclerosis 13.0
Hypertensive renal failure 13.0
Carotid arteriosclerosis 13.0
NIDDM4 13.0
microalbuminuria 13.0
stage IIB melanoma 13.0
NIDDM3 13.0
Clinical diabetic nephropathy 12.0
Incipient diabetic nephropathy 11.4
Renal parenchymal hypertension 11.0
Cardiac dilatation 10.6
NIDDM2 10.5
Dyschromatopsia 10.4
Sickle cell nephropathy 10.1
NIDDM1 10.0
CSME 10.0
Macroangiopathy 9.8
diabetic nephropathy 9.6
background retinopathy 9.4
Nodular glomerulosclerosis 9.2
Diabetic microangiopathy 8.9
Fanconi-like syndrome 8.8
Proliferative retinopathy 8.7
Non-dipping 8.7
Cardiovascular morbidity 8.6
hypertensive retinopathy 8.4
HIVAN 8.4
retinopathy 8.2
metabolic syndrome X 8.1
kidney hypertrophy 8.1
Lacunar infarction 8.0
Proteinuria 7.9
proteinuria 7.9
nephrosclerosis 7.8
renal disease 7.7
Hypertensive retinopathy 7.7
Hypertensive retinopathy 7.7
Reflux nephropathy 7.5
glomerulopathy 7.4
hypertensive cardiomyopathy 7.4
type 1 diabetes 7.4
Multicystic dysplastic kidney 7.3
white coat hypertension 7.3
Rapidly progressive glomerulonephritis 7.3
Chronic kidney disease (CKD) 7.2
Rabson-Mendenhall syndrome 7.1
Wolcott-Rallison syndrome 7.1
ventricular hypertrophy 7.1
craniofrontonasal syndrome 7.0
Renal amyloidosis 7.0
hyporeninemic hypoaldosteronism 7.0
hypertensive nephropathy 7.0
orthostatic proteinuria 7.0
acroparesthesia 6.9
autonomic neuropathy 6.9
GSD I 6.9
essential hypertension 6.9
MODY3 6.9
borderline hypertension 6.9
cardiovascular risk factor 6.9
diabetic retinopathy 6.8
NPHS2 6.8
diabetic angiopathy 6.8
type 2 diabetes 6.6
Endothelial dysfunction 6.6
abdominal obesity 6.6
DM2 6.5
MODY1 6.5
renal impairment 6.5
glomerulosclerosis 6.5
MODY2 6.5
dyslipidemia 6.4
systolic hypertension 6.4
JMS 6.4
renal insufficiency 6.3
uncomplicated hypertension 6.3
peripheral vascular disease 6.2
IRMA 6.2
hypohidrosis 6.2
renal failure 6.1
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Symptom
excessive urination 9.0
Signs and Symptoms 5.8
leg cramps 5.8
disturbed balance 5.1
acute low back pain 4.8
ketonuria 4.8
Burning 4.7
overweight 4.0
muscle cramps 3.1
HSA 3.0
polyuria 3.0
tingling 2.6
Sedation 2.6
angina 2.5
alexithymia 2.2
polydipsia 1.8
cough 1.7
snoring 1.5
hepatomegaly 1.5
sleepiness 1.3
dizziness 1.3
dysarthria 1.1
hepatosplenomegaly 0.8
acute stress 0.8
constipation 0.6
lethargy 0.5
chest pain 0.5
myalgia 0.3
tinnitus 0.3
exhaustion 0.2
arthralgia 0.1
hypercapnia -0.0
diarrhea -0.1
low back pain -0.3
thinning -0.5
back pain -0.6
anorexia -0.8
headache -0.8
abdominal pain -1.0
hypothermia -1.1
pain -1.1
anesthesia -1.2
weakness -1.3
nausea -1.6
starvation -1.7
fatigue -1.7
dyspnea -1.8
Drug
Dilazep dihydrochloride 11.4
Succinic Acid 11.4
Lotrel 10.5
Amiloride hydrochloride 9.8
Norvasc 9.1
Benazepril hydrochloride 8.9
Benfotiamine 8.8
Olmesartan 8.4
Alacepril 8.3
Gliquidone 8.2
Ramipril 8.2
Trandolapril 8.1
Lercanidipine 8.0
Perindopril 7.6
Cilnidipine 7.5
Insulin lispro 7.3
Tenidap 7.2
Azelnidipine 7.1
Albumin 7.1
Losartan potassium 7.1
Indapamide 7.0
Amlodipine besylate 7.0
Valsartan 6.9
Gliclazide 6.7
Methyldopa 6.6
Cicletanine 6.6
Cilostazol 6.3
Indapamide 6.1
Lacidipine 6.0
Iopromide 6.0
Isoptin 5.9
Cilazapril 5.8
Rebamipide 5.7
Rosiglitazone 5.6
Rimonabant 5.6
NAG 5.5
Guar gum 5.4
Angiotensin II 5.3
EPI 5.2
Aminoguanidine 5.2
Isradipine 4.9
Aliskiren 4.9
Captopril 4.8
IPD 4.7
ADM 4.7
Bayer 4.6
DM1 4.6
ROC 4.4
Orlistat 4.4
Hydrochlorothiazide 4.3
Tenofovir 4.3
CTT 4.3
Liraglutide 4.2
Epigallocatechin 4.1
Rosuvastatin 4.1
CVA 4.1
Cibacron Blue 4.1
Vitamin A 4.0
Clofibrate 3.8
Diurnal 3.8
Urokinase 3.7
Vitamin E 3.6
Nephron 3.6
Dakar 3.5
BH4 3.4
PMPA 3.3
CPR 3.2
Atenolol 3.2
Amiloride 3.1
Nephron 3.1
Salbutamol 2.9
Clopidogrel 2.8
Vitamin B 2.7
nitroglycerin 2.6
ZnCl2 2.6
ZnCl2 2.6
Lovastatin 2.6
Dial 2.6
Growth hormone 2.4
Amiloride 2.4
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Enzyme
matrix metalloproteinase 10 7.8
creatininase 7.1
beta-D-fucosidase 7.0
ACE 6.7
tyrosine phenol-lyase 6.5
renin 6.1
thrombin-activatable fibrinolysis inhibitor 6.0
prostasin 5.7
alanine aminopeptidase 5.4
methionine synthase reductase 5.3
12-lipoxygenase 4.8
aldose reductase 4.6
biotinidase 4.3
SCP 4.1
leucine aminopeptidase 3.9
kallikrein 3.8
dipeptidyl peptidase IV 3.8
tissue plasminogen activator 3.7
MTD 3.7
CD13 3.7
tissue kallikrein 3.7
PAH 3.7
transketolase 3.6
type III procollagen 3.5
isoamylase 3.4
SST 3.4
AGT 3.4
alpha-galactosidase 3.2
delta-aminolevulinic acid dehydratase 3.1
methylenetetrahydrofolate reductase 2.9
methylenetetrahydrofolate reductase 2.9
CAD 2.9
CAD 2.8
CAD 2.8
N-acetyltransferase 2.8
hexosaminidase 2.7
lysyl oxidase 2.7
NADPH oxidase 2.7
NADPH oxidase 2.6
plasmin 2.6
BMT 2.6
chymase 2.6
LPL 2.5
lipoprotein lipase 2.5
alpha-glucosidase 2.5
acyl-CoA dehydrogenase 2.5
glucokinase 2.5
3-hydroxy-3-methylglutaryl coenzyme A reductase 2.4
deoxyribonuclease 2.4
MAT 2.4
alpha-mannosidase 2.4
deoxyribonuclease 2.4
glucose-6-phosphatase 2.4
5'-nucleotidase 2.3
aryl hydrocarbon hydroxylase 2.3
ceruloplasmin 2.2
DTA 2.2
MAT 2.2
cathepsin L 2.0
chondroitinase 2.0
cathepsin D 1.9
AMPK 1.9
lactase 1.9
chondroitinase 1.9
soluble epoxide hydrolase 1.8
PDK1 1.8
APC 1.8
TAT 1.7
thrombin 1.6
AMP-activated protein kinase 1.6
CPR 1.6
urokinase-type plasminogen activator 1.6
glutathione peroxidase 1.5
lactate dehydrogenase 1.4
gamma-glutamyl transpeptidase 1.4
AST 1.4
protein kinase C 1.4
hyaluronidase 1.4
beta-glucosidase 1.3
thromboplastin 1.3
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Compound
Dilazep dihydrochloride 11.4
Irbesartan 9.2
Fosinopril 8.7
Moexipril 8.3
Candesartan cilexetil 8.2
Telmisartan 7.8
Candesartan 7.7
5-aminovalerate 7.6
Perindopril 7.3
Canrenone 7.3
LPR 7.3
Rilmenidine 7.2
creatinine 7.1
6R-BH4 6.9
Eplerenone 6.8
Pima 6.8
Valacyclovir 6.8
MHT 6.7
pentosidine 6.7
Moxonidine 6.6
Eprosartan 6.6
Enalapril 6.6
Hippuran 6.6
Biuret 6.4
Losartan 6.3
FUR 6.2
ADMA 6.1
12(S)-HETE 6.1
Cerivastatin 6.1
Amlodipine 5.9
DBP 5.9
Quinapril 5.9
Pantoprazole 5.9
8-iso-PGF2alpha 5.9
Sorbinil 5.8
Diabetol 5.8
Indoxyl sulfate 5.8
DBP 5.8
Angiotensin II 5.7
PCB 126 5.6
PIH 5.6
Gb3 5.6
DQ1 5.6
1,5-AG 5.6
Cystine 5.5
Fructosamine 5.5
Diabetol 5.4
11-dehydro-thromboxane 5.4
Bisoprolol 5.3
Pioglitazone 5.3
hippurate 5.3
12-hydroxyeicosatetraenoic acid 5.3
aldosterone 5.3
NDS 5.2
Hydrochlorothiazide 5.2
OCDD 5.1
Carvedilol 5.1
DCA 5.0
DCA 5.0
4-Hydroxynonenal 4.9
Rhein 4.9
Angiotensin I 4.9
Pentoxifylline 4.9
Doxazosin 4.8
IPD 4.8
methylguanosine 4.7
Fibrinogen 4.7
Apocynin 4.7
Fenofibrate 4.7
Heparan sulfate 4.7
Melamine 4.6
homocysteine 4.6
HBA 4.6
Tetrahydrobiopterin 4.5
Cotinine 4.5
Acarbose 4.4
STZ 4.4
Inulin 4.4
Hydroxyurea 4.4
DOCA 4.3
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