Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0730345 (microalbuminuria)
 4,018 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Detailed examination was performed in 1781 subjects with occult fasting hyperglycaemia (FH), 211 known diabetics (KD), and their corresponding non-diabetic controls (80 CFH, 216 CKD), all found by screening of a well-defined population aged 60-74 years. All but one FH and 90% of KD could be classified as non-insulin-dependent diabetes mellitus (NIDDM) when evaluated by a glucagon-C-peptide test. Urine excretion of albumin and beta 2-microglobulin and the creatinine clearance were examined over 1 hour in the resting state. The results show that elderly non-diabetics have a wide range of albumin excretion rates. Occult fasting hyperglycaemia is associated with increased albuminuria not detectable by conventional tests for urinary proteins in males, whereas females do not have increased microalbuminuria. Known NIDDM is associated with increased albuminuria in both sexes indicating a sex difference in the threshold for albuminuria only in subjects with occult fasting hyperglycaemia. The albumin/beta 2-microglobulin excretion ratio indicates that the higher albumin excretion rates associated with occult fasting hyperglycaemia and known NIDDM are of glomerular origin.
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PMID:Microalbuminuria in elderly hyperglycaemic patients and controls. 295 Nov 94

The use of services from the primary health care system and hospital outpatient clinics was studied in persons aged 60-74 years. We studied 228 persons with known diabetes (KD) (52 insulin treated, 101 OHA, 66 diet, 9 untreated) and 87 with fasting hyperglycaemia (FH) and compared with sex and age matched controls (223 CKD, 82 CFH). Information on all services provided by the primary health care system during the 12 months before ascertainment was obtained from local and national registers. FH did not receive more primary care services and did not visit outpatient clinics more than controls. Two to three times more KD than controls received all kinds of services from general practice or visited outpatient clinics. No difference was seen for specialists, except for dentists and otologists who provided fewer services to KD than to CKD. Of insulin treated KD 56% had greater than or equal to 10 contacts with physicians during the year, independent of residual beta-cell function. The corresponding proportions for OHA-treated and diet treated KD were 27% and 29%. Outpatient clinics were visited by 79% of insulin treated KD (88% with high and 65% with low C-peptide secretion), 26% of OHA-treated KD and 33% of diet-treated KD. The prevalence of ischaemic heart disease, hypertension, and microalbuminuria was not increased in the KD using most primary care services.
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PMID:Ambulatory medical care for elderly diabetics: the Fredericia survey of diabetic and fasting hyperglycaemic subjects aged 60-74 years. 296 9