Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0730345 (
microalbuminuria
)
4,018
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To investigate the role of
vitronectin
in the progression of diabetic nephropathy, plasma concentrations of
vitronectin
were measured by enzyme-linked immunosorbent assay in patients with diabetes mellitus and compared with normal control subjects. In diabetic patients with normoalbuminuria and
microalbuminuria
, plasma concentrations of
vitronectin
were significantly higher than those of control subjects. Plasma concentrations of
vitronectin
in diabetic patients with chronic renal failure were significantly lower than those with normal renal function. There was a significant positive correlation between plasma concentration of
vitronectin
and blood platelet counts. In the early stage of diabetic nephropathy,
vitronectin
may be increased caused by synthesis from activated platelets. With progression of diabetic nephropathy, plasma
vitronectin
may be decreased because of accumulation in sclerotic glomeruli and arteriosclerotic lesions. In conclusion, the plasma concentration of
vitronectin
appears to be an important marker for the progression of diabetic nephropathy.
...
PMID:Changes in plasma concentrations of vitronectin in patients with diabetic nephropathy. 752 68
