Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0729233 (Thoracic)
 6,478 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
smooth muscle myosin heavy chain SM2 11.3
ATS 9.3
ZNF444 9.1
MTL5 8.9
cysteine dioxygenase type 1 8.9
P2RX5 8.9
BAP-1 8.9
surfactant protein A1 8.8
CRKL protein 8.6
SECT 8.5
GK2 8.4
POLE2 8.2
tesmin 8.2
OLF 8.1
Ig kappa chain 8.1
SEMG 8.1
Cep120 8.0
spinocerebellar ataxia 7 7.8
WDR35 7.7
ZO2 7.7
V5-6 7.7
BTS 7.6
Alpha-1 antitrypsin 7.6
KAB1 7.6
MS4A2 7.5
SAP-2 7.4
TUBE 7.4
MMP19 7.3
DGK 7.3
MCM7 protein 7.2
ETFA 7.1
NSR1 7.0
HERMES 6.9
paired box gene 8 6.9
DLGAP5 6.9
IPAF 6.9
TNIK 6.9
SFTPA1 6.8
RFC4 6.8
FOXE3 6.8
MYLK 6.8
CD157 6.7
HLA-A33 6.7
KLF17 6.6
Odin 6.6
STS 6.6
PAT2 6.6
KCNMB1 6.5
ILF 6.5
Transcription factor E3 6.4
lok 6.4
HDH 6.3
T12 6.3
PRKG1 6.2
PTGDR 6.2
TMEM127 6.2
Z-protein 6.2
CRKL 6.1
T11 6.0
OPLL 6.0
granulocyte chemotactic protein-2 6.0
ARSA 5.9
T10 5.9
AIS 5.9
ninein 5.9
cardiac calsequestrin 5.8
MDH2 5.8
TIS) 5.8
FLIR 5.8
GREAT 5.7
FMR2 5.7
osteoglycin 5.7
CLCR 5.7
MCM5 5.7
LRC 5.7
SYS 5.7
FEV 5.7
SIN1 5.6
TTF1 5.5
thyroid transcription factor-1 5.5
napsin A 5.5
myosin phosphatase target subunit 1 5.5
PEF 5.5
SLC34A2 5.4
V75 5.4
scavenger receptor class B type 1 5.4
CD124 5.3
ITCH 5.3
K23 5.3
ERAS 5.3
CAV 5.3
COPD 5.3
MM46 5.2
INV 5.2
IFITM1 5.2
Trehalase 5.2
metastasis-associated protein 5.1
SPS1 5.1
CASQ2 5.1
MCM4 5.1
CRB 5.1
RalGDS 5.1
ACTA2 5.1
CHI3L1 5.1
BL2 5.1
DLD 5.0
TED 5.0
p63) 5.0
phospholipase inhibitor 4.9
Cardiac troponin I 4.9
MIP1 4.9
PLAP 4.9
Glycoprotein IIb 4.9
Wilms tumor 1 4.9
Car 4.8
PAMP 4.8
NPO 4.8
TGFB2 4.8
BMF 4.8
delta-sarcoglycan 4.8
neuronal apoptosis inhibitory protein 4.8
NUT 4.8
RYR2 4.8
ABG 4.8
thyroid transcription factor 1 4.8
FANCI 4.7
RITA 4.7
MTA1 4.7
EPP 4.7
GRASP 4.7
VHL protein 4.7
Transforming growth factor-alpha 4.7
COB 4.7
E6-AP 4.7
dach 4.6
Angiopoietin-2 4.6
SLC7A11 4.6
TYMS 4.6
6A1 4.6
OX2 4.6
UDG 4.6
NIP 4.6
FBN1 4.6
PLAG1 4.5
SCAP 4.5
EPAS1 4.5
HTX 4.5
alpha-1 antitrypsin 4.5
p150Glued 4.5
COP 4.5
pancreatic stone protein 4.5
ASK 4.5
LAMA 4.5
MCM7 4.4
CMAP 4.4
ENDO 4.4
STE20 4.4
FFR 4.4
PNN 4.4
pericentrin 4.4
more...
Disease
thoracic disc degeneration 12.3
Thoracic 12.3
Unresolved pneumonia 12.3
Aortic Disease 11.5
Pleural endometriosis 10.9
Thoracic radiculopathy 10.3
RB-ILD 10.3
Tuberculous arthritis 10.2
pulmonary circulation disorder 10.1
Chronic gastric volvulus 9.7
Iatrogenic pneumothorax 9.7
Oesophageal necrosis 9.7
Gastroesophageal intussusception 9.7
Rheumatoid lung 9.7
Nerve paralysis 9.5
Pulmonary Pathology 9.5
MSMD 9.5
pleural disorder 9.5
Chylous effusion 9.5
Thoracic Disease 9.5
Respiratory bronchiolitis-associated interstitial lung disease 9.3
Pleomorphic malignant fibrous histiocytoma 9.3
Postoperative atelectasis 9.3
Extrahepatic bile ducts 9.1
thoracic disc prolapse 9.1
Pericardial cyst 9.1
IgE-mediated allergic asthma 8.9
Sensory deficit 8.9
Traumatic chylothorax 8.9
Primary cutaneous nocardiosis 8.9
thoracic neoplasm 8.9
cardiovascular infection 8.8
Empyema necessitans 8.8
Pleural metastases 8.7
Rasmussen's aneurysm 8.7
stage IIIB NSCLC 8.6
Thoracic aortic aneurysm 8.6
Cor Pulmonale 8.6
Nonspecific interstitial pneumonia 8.6
Bone Dysplasia 8.6
Bacterial pericarditis 8.6
Pulmonary vasculitis 8.5
Tricuspid valve disease 8.5
ERS 8.4
Neuromuscular scoliosis 8.4
Acute esophagitis 8.3
Mediastinal mass 8.3
epiphysitis 8.2
Malignant acanthosis nigricans 8.2
Postoperative stroke 8.1
Pulmonary failure 8.1
Catamenial pneumothorax 8.1
NSIP 7.9
Flail chest 7.9
fibroelastosis 7.9
stage IIIA NSCLC 7.9
bone abscess 7.9
Pulmonary calcification 7.9
Cardiorespiratory failure 7.9
community acquired pneumonia 7.8
metastatic parathyroid carcinoma 7.8
chylopericardium 7.8
Endobronchial lipoma 7.7
Organizing pneumonia 7.7
BALT lymphoma 7.7
Mucinous cystadenocarcinoma 7.6
Disseminated aspergillosis 7.6
Thymolipoma 7.6
Cervical lymphadenitis 7.6
Meningeal melanocytoma 7.6
Pleural infection 7.6
lung consolidation 7.5
Angiostrongyliasis 7.5
Wound sepsis 7.5
Restrictive lung disease 7.5
chylothorax 7.5
systemic blastomycosis 7.4
Postoperative pneumonia 7.4
Reexpansion pulmonary edema 7.4
hemopneumothorax 7.3
Gastric dilatation 7.3
Obesity hypoventilation syndrome 7.3
Tarlov cyst 7.3
Cauda equina 7.3
Spinal epidural hematoma 7.3
Bovine respiratory disease complex 7.2
limited-stage small cell lung cancer 7.2
megaesophagus 7.2
Tracheal rupture 7.2
Ganglioneuroblastoma 7.1
Idiopathic pneumonia syndrome 7.1
Papillary adenocarcinoma 7.0
Cerebral aspergillosis 7.0
Adenocarcinoma in situ 7.0
Congenital tuberculosis 7.0
Spontaneous pneumothorax 6.9
Splenosis 6.9
Pleomorphic carcinoma 6.9
Ganglioneuroblastoma 6.8
Pulmonary blastoma 6.8
recurrent SCLC 6.8
pneumothorax 6.8
Late pregnancy 6.8
Lymphangiomatosis 6.8
UIP 6.8
Ectopic ACTH syndrome 6.8
Coronary artery stenosis 6.8
Mycobacterium kansasii infection 6.8
Pulmonary veno-occlusive disease 6.7
Primary mediastinal large B-cell lymphoma 6.7
broncholithiasis 6.7
Aortic rupture 6.7
anthracosilicosis 6.7
extensive stage SCLC 6.7
honeycomb lung 6.7
empyema 6.7
Vulva 6.6
pulmonary granuloma 6.6
Pleura 6.6
Nonimmune hydrops fetalis 6.6
pyopneumothorax 6.6
gastrointestinal reflux 6.6
Pleura 6.6
bronchioloalveolar carcinoma 6.5
anthracosis 6.5
Spinal cord infarction 6.5
complete paraplegia 6.5
Necrotizing vasculitis 6.5
traumatic lung 6.5
STS 6.5
Scheuermann's disease 6.5
Pancoast tumor 6.5
obstructive airway disease 6.5
Spinal cord ischemia 6.4
fibrothorax 6.4
Oppenheim 6.4
meningomyelitis 6.4
Twiddler's syndrome 6.4
aortic aneurysm 6.4
Pulmonary sarcoidosis 6.4
bronchiectasis 6.4
recurrent thyroid cancer 6.3
ACTH-dependent Cushing's syndrome 6.3
Pancoast 6.2
aerophagia 6.2
hemangiosarcoma 6.2
Homozygous familial hypercholesterolemia 6.2
classic Kaposi's sarcoma 6.2
Esophageal perforation 6.2
Plastic bronchitis 6.2
nodular malignant melanoma 6.2
pleural plaque 6.1
interstitial lung disease 6.1
actinomycetoma 6.1
Hemodynamic instability 6.1
Latent tuberculosis 6.1
Harley 6.1
silicotuberculosis 6.1
Oropharyngeal dysphagia 6.1
tension pneumothorax 6.0
more...
Symptom
Expiratory dyspnea 10.7
Sulfur granules 9.9
runny eyes 9.9
thoracic spine dysfunction 9.9
Monoparesis 9.5
Rhonchi 9.3
Radiating pain 8.7
cervical spine dysfunction 8.4
Thoracic pain 7.9
reproductive problem 7.1
Lhermitte's sign 6.9
sighing 6.7
labored breathing 6.5
productive cough 6.5
Platypnea 6.5
diastolic murmurs 6.1
hemoptysis 6.0
feeling tired 6.0
precordial pain 5.8
chronic cough 5.8
blushing 5.8
paraparesis 5.7
tachypnea 5.7
respiratory problem 5.6
wheezing 5.4
Respiratory symptoms 5.4
cough 5.4
pleuritic chest pain 5.4
dyspnea 5.4
shortness of breath 5.3
persistent cough 5.3
rales 5.3
non-productive cough 5.1
lethargy 5.1
chest tightness 5.0
Physical findings 4.9
Deafferentation 4.9
throat irritation 4.8
Spastic 4.8
Regurgitation 4.7
regurgitation 4.7
back pain 4.6
chest pain 4.5
abnormal breathing 4.5
leg edema 4.5
analgesia 4.4
tingling 4.3
respiratory distress 4.2
Postoperative pain 4.2
nasal discharge 4.2
retching 4.2
decreased appetite 4.1
numbness 4.0
cyanosis 4.0
neck pain 3.9
anorexia 3.8
shoulder pain 3.8
neuralgia 3.8
prostration 3.7
exertional dyspnea 3.7
night sweats 3.6
abdominal fullness 3.6
consciousness disturbance 3.6
belching 3.6
hypertonia 3.6
paresthesia 3.4
blackout 3.4
stridor 3.4
sneezing 3.4
pallor 3.3
syncopal episodes 3.3
leg pain 3.3
lightheadedness 3.3
anesthesia 3.3
weakness 3.2
emaciation 3.2
colic 3.2
hyperesthesia 3.2
asthenia 3.2
adenitis 3.1
collapse 3.1
excessive sweating 3.1
hepatomegaly 3.1
Gastrointestinal symptoms 3.1
halitosis 3.0
presyncope 3.0
atypical chest pain 2.9
acute pain 2.9
syncope 2.9
hypercapnia 2.9
Sedation 2.9
limb pain 2.9
snoring 2.8
flank pain 2.8
polydipsia 2.7
hoarseness 2.7
paresis 2.6
hypocapnia 2.5
distraction 2.5
hepatosplenomegaly 2.5
clubbing 2.5
hemiplegia 2.3
pain 2.3
otalgia 2.3
polyuria 2.3
blurred vision 2.2
eds 2.2
Hudson 2.2
hypothermia 2.2
discomfort 2.1
abnormal gait 2.1
hypoproteinemia 2.1
epigastric pain 2.1
vomiting 2.1
abdominal pain 2.0
nausea and vomiting 2.0
discomfort 2.0
dysuria 2.0
low back pain 2.0
sleepiness 1.9
spasticity 1.9
myalgia 1.9
sore throat 1.8
chills 1.8
sciatica 1.7
dizziness 1.6
fatigue 1.6
angina 1.6
enuresis 1.6
bloating 1.6
Ill 1.4
cachexia 1.4
splenomegaly 1.3
acute abdominal pain 1.3
pelvic pain 1.3
fever of unknown origin 1.2
heartburn 1.2
ataxia 1.1
exhaustion 1.1
rhinorrhea 1.1
Wind 0.9
dry eye 0.9
ENT 0.9
thinning 0.8
nausea 0.7
HSA 0.7
cancer pain 0.7
acute abdomen 0.7
bone pain 0.7
ophthalmoplegia 0.6
arthralgia 0.5
cerebellar ataxia 0.4
memory loss 0.4
spasm 0.4
headache 0.4
diarrhea 0.4
apathy 0.3
constipation -0.1
hyperoxia -0.1
overweight -0.1
more...
Drug
Sodium cromoglicate 9.5
Efaproxiral 9.3
Volley 9.1
Pyrolite 8.3
Peanut oil 7.2
Spiriva 7.2
Paraplatin 6.7
Fluticasone propionate 6.4
Navelbine 6.3
Maxon 6.0
Ketalar 5.7
Atrovent 5.6
Alteplase 5.4
Alteplase 5.3
Ipriflavone 5.3
Alteplase 5.2
Isoniazid 5.2
Vinorelbine 5.1
PFT 4.9
Vardenafil 4.8
Gemzar 4.7
Bivalirudin 4.6
Talc 4.5
Gliclazide 4.4
Anakinra 4.3
Clodronate 4.3
CDX 4.3
Apixaban 4.1
Methylprednisolone 4.0
Sumatran 4.0
Triad 4.0
Mirtazapine 4.0
Asthma 4.0
Fondaparinux 3.9
Dexon 3.9
Perindopril 3.9
Flavin 3.9
Trib 3.9
Triad 3.9
CDX 3.8
Modafinil 3.7
Bupivacaine 3.7
SBT 3.6
Gefitinib 3.6
Pemetrexed 3.6
Azithromycin 3.6
Omalizumab 3.6
Irinotecan 3.6
Aminoguanidine 3.5
Award 3.5
Trifluoperazine 3.5
Gastro 3.4
Valsartan 3.4
Orion 3.4
Cardiovasc 3.3
Vicryl 3.2
Denosumab 3.2
TES 3.1
Infliximab 3.1
Infliximab 3.1
CED 3.1
Tuberculin 3.1
Metrizamide 3.1
linolenate 3.0
RFP 3.0
Serum albumin 3.0
Taxotere 3.0
Meropenem 3.0
IL-1ra 2.8
CTA 2.8
GEO 2.7
CPR 2.5
Fraction 2.5
Docetaxel 2.5
Amoxicillin 2.4
Aprotinin 2.4
Photofrin 2.4
Adriamycin 2.4
TTC 2.4
CPT-11 2.4
Sodium nitroprusside 2.3
nitroglycerin 2.3
Check 2.3
Salbutamol 2.3
Frontal 2.3
Taxol 2.2
MRC 2.1
CAM 2.1
CDP 2.1
Phentolamine 2.1
Horizon 2.0
Vitamin B 2.0
Methylene blue 1.9
ETS 1.9
Phenytoin 1.9
Alliance 1.9
BLM 1.9
Posture 1.9
ETA 1.8
Prednisolone 1.7
Amiloride 1.7
AZT 1.7
balanced salt solution 1.7
Bayer 1.6
Albumin 1.6
Atropine 1.6
Angiotensin II 1.5
ENT 1.5
Amiloride 1.4
Monit 1.3
Itraconazole 1.3
Propofol 1.2
Dakar 1.2
ACT 1.2
TAT 1.0
Ouabain 1.0
ROC 0.9
Nitric Oxide 0.9
MAP 0.9
Rituximab 0.8
Indomethacin 0.6
CTX 0.5
Kenyan 0.5
Nephron 0.5
Fluorescein 0.4
niacin 0.4
ampicillin 0.2
Portal 0.2
ABC 0.2
Glutathione -0.1
ICI -0.1
Leaf -0.1
Histamine -0.2
CaCl2 -0.4
CaCl2 -0.4
CaCl2 -0.4
PTH -0.5
THF -0.7
citric acid -1.0
ascorbate -1.2
Nephron -1.3
IL-2 -1.6
Gel -1.6
Dial -1.6
CSF -1.7
vitamin E -1.8
ROS -2.0
caffeine -2.1
NADH -2.2
IFN-gamma -2.6
Dermatol -3.4
lysine -3.6
Enzyme
GK2 7.8
glycerol 3-phosphate dehydrogenase 4.6
diacylglycerol kinase 4.3
lysyl oxidase 4.0
ACAT 3.8
BAL 3.6
MTD 3.0
NAT 2.9
type III procollagen 2.8
FAST 2.7
MCS 2.7
PRA 2.6
PKG 2.6
PAT 2.5
TSP-1 2.5
FFT 2.5
ALDH 2.5
Rex 2.4
guanylate cyclase 2.4
NO synthase 2.3
tissue plasminogen activator 2.3
farnesyltransferase 2.2
CAD 2.2
CAD 2.2
CAD 2.1
matrix metalloproteinase 2 2.1
arylsulfatase 2.0
dihydropyrimidine dehydrogenase 2.0
MAP 2.0
neutrophil elastase 1.9
dopamine beta-hydroxylase 1.8
gamma-glutamylcysteine synthetase 1.8
histidine decarboxylase 1.7
MDR 1.7
DAT 1.7
deoxyribonuclease 1.7
farnesyltransferase 1.7
chalcone synthase 1.7
elastase 1.7
deoxyribonuclease 1.7
Alternating 1.7
beta-lactamase 1.6
DTA 1.5
phosphoglucose isomerase 1.5
AOR 1.5
CD13 1.5
cholesterol acyltransferase 1.3
heme oxygenase 1.2
MMP 1.2
aldehyde dehydrogenase 1.2
PAH 1.2
NADPH oxidase 1.1
ACE 1.1
TAT 1.0
lactate dehydrogenase 1.0
CD10 1.0
DNase 0.9
NADPH oxidase 0.9
CPR 0.9
thromboplastin 0.9
MDP 0.9
myosin light chain kinase 0.9
renin 0.8
firefly luciferase 0.8
gamma-glutamyl transpeptidase 0.7
protein phosphatase 2A 0.7
aspartate aminotransferase 0.7
CPT 0.6
ricin 0.6
sulfatase 0.6
aldose reductase 0.6
aldolase 0.5
CPT 0.5
S1 nuclease 0.4
PDE 0.4
enolase 0.4
alanine aminotransferase 0.4
ERK 0.3
superoxide dismutase 0.1
MEK 0.1
CPT 0.1
malate dehydrogenase 0.1
creatine kinase 0.1
transcriptase 0.1
DNA methyltransferase -0.0
ceruloplasmin -0.0
hexokinase -0.1
alkaline phosphatase -0.1
phosphorylase -0.2
phospholipase C -0.3
phosphodiesterase -0.3
CYP3A4 -0.4
ribonuclease -0.4
ribonuclease -0.4
catalase -0.5
prostate-specific antigen -0.5
NOS -0.6
glutathione peroxidase -0.6
tyrosine hydroxylase -0.6
APC -0.7
thrombin -0.8
xanthine oxidase -0.8
trypsin -0.8
calcineurin -0.8
pepsin -0.8
tyrosinase -0.9
lipase -0.9
peroxidase -0.9
adenylate cyclase -1.0
urokinase-type plasminogen activator -1.1
lysozyme -1.1
phosphatidylinositol 3-kinase -1.2
protein kinase -1.2
protein kinase C -1.3
AMPK -1.3
luciferase -1.4
acid phosphatase -1.4
AMP-activated protein kinase -1.4
mitogen-activated protein kinase -1.5
beta-galactosidase -1.6
focal adhesion kinase -1.6
RNase -1.7
RNA polymerase -1.8
caspase-3 -1.9
RNase -1.9
collagenase -1.9
proteasome -2.6
reverse transcriptase -2.7
ATPase -2.7
ACS -4.0
Compound
ethanimidamide 8.9
Eriochrome Cyanine R 8.5
1-tridecene 7.7
Kavain 7.4
Maneb 7.1
Hydrocodone 6.6
Retinyl acetate 6.3
BAPN 6.2
T11 6.2
Trifluralin 6.2
Fluticasone 6.1
Calycosin 6.0
T10 6.0
Ectoine 5.8
Pyridinoline 5.8
Fluticasone 5.8
Diosmin 5.8
Prilocaine 5.7
FOA 5.7
Nefazodone 5.6
Hyperoside 5.6
2-ethylhexanoic acid 5.4
Methacholine 5.3
Ergotamine 5.2
Pyruvate 5.2
Tirofiban 5.2
NCD 5.2
Captan 5.1
Esculetin 5.0
Cefuroxime 5.0
AHA 5.0
Cyclone 4.9
AME 4.8
TMQ 4.8
Mibefradil 4.8
Fusidic acid 4.8
Aztreonam 4.7
Flavone 4.6
Cardamine 4.6
ICRF-187 4.6
Lentinan 4.6
Telithromycin 4.5
Relaxant 4.4
Trimethylamine 4.4
ASK 4.3
Oxycodone 4.3
Mirtazapine 4.2
Lithium chloride 4.2
nonanoic acid 4.2
nonanoic acid 4.2
nonanoic acid 4.2
Methylprednisolone 4.1
Dexmedetomidine 4.1
Coronal 4.1
INH 4.1
Chlorambucil 4.1
T13 4.1
nonanoic acid 4.1
Thiopental 4.1
Betulinic acid 4.0
Elastin 4.0
Azithromycin 4.0
TNM 4.0
2,4,5-T 4.0
Ach 3.9
TEG 3.9
Metyrapone 3.8
Metyrapone 3.7
DLT 3.7
Bupivacaine 3.7
Emery 3.7
BSO 3.7
Prone 3.7
DEA 3.7
Labetalol 3.6
DEA 3.6
Topotecan 3.6
TBC 3.6
Methysergide 3.6
BzATP 3.6
Terbutaline 3.6
Epirubicin 3.6
12-hydroxyeicosatetraenoic acid 3.6
AIR 3.6
TES 3.6
CPB 3.6
DEA 3.6
Disodium cromoglycate 3.5
AAT 3.5
nonanoic acid 3.5
Trifluoperazine 3.5
A 71 3.5
A 3 3.5
CCNU 3.4
Flavin 3.4
SVC 3.4
Venlafaxine 3.4
Hexamethonium 3.4
Diazoxide 3.4
Cortisone 3.4
Bordeaux 3.4
Pyrazinamide 3.3
BAS 3.3
Nitro-L-arginine 3.3
Tyramine 3.3
Paroxetine 3.3
Azathioprine 3.3
Protoporphyrin IX 3.3
Salbutamol 3.2
Tigecycline 3.2
Conjugated linoleic acid 3.2
isopropyl myristate 3.2
BAL 3.2
Danazol 3.1
TAA 3.1
Atorvastatin 3.1
Topotecan 3.1
Bupropion 3.1
Organon 3.1
ACI 3.1
Thiobarbituric acid 3.1
DBD 3.0
Etanercept 3.0
Tempol 3.0
DOCA 2.9
prostaglandin F1 2.9
Clarithromycin 2.9
Phenylephrine 2.9
Wellcome 2.8
CBDCA 2.8
CBDCA 2.8
HAP 2.8
Rifampicin 2.8
Clindamycin 2.8
A 42 2.7
Erythromycin 2.7
RELA 2.7
Amikacin 2.7
Metoprolol 2.7
AFC 2.7
L-PAM 2.7
PAT 2.7
L-PAM 2.6
Pioglitazone 2.6
CAP 2.6
Pentoxifylline 2.6
Amiodarone 2.6
Metoprolol 2.6
AICAR 2.6
INT 2.6
MOD 2.5
CHIP 2.5
Acetazolamide 2.5
Enalapril 2.5
Fibrinogen 2.5
Suramin 2.5
Vincristine 2.4
Formal 2.4
Pima 2.4
Chloroquine 2.4
more...