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Query: UMLS:C0729233 (Thoracic)
 6,478 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thoracic duct lymph (TDL) of nonimmune rats and mice was examined for the presence of antigen-carrying cells immediately following a single injection of 125I-labelled or fluorescence-labelled serum protein antigens. Small numbers of cells laden with antigen (approximately 1/2000 to 1/5000) were identified in TDL and blood by autoradiography or fluorescence microscopy. The antigen-laden (Ag-L) cells resembled macrophages in that a large number adhered to plastic, they phagocytosed bacteria or a particulate dye, were non-specific esterase positive, radioresistant and could take up more than one antigen at one time in vivo. Surface phenotyping using monoclonal antibodies against rat cell markers established that Ag-L cells did not express Ia determinants. The results suggest the existence of a subpopulation of macrophage-related cells that may be involved in the transport of antigen and in stimulation of antibody responses.
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PMID:Antigen transport. I. Demonstration and characterization of cells laden with antigen in thoracic duct lymph and blood. 712 28

The present study was designed to investigate whether N-alpha-tosyl L-arginine methyl ester [TAME]-esterase activation could be the result of endothelial dysfunction. Thoracic aorta from rats was mounted in an organ bath containing Krebs solution. Intact and endothelium denuded aortic strips were challenged with different concentrations of TAME (10(-15)-10(-1) m). The effects of aspirin, a cyclo-oxygenase pathway inhibitor, were also studied on [TAME]-esterase induced contraction on rat aorta strips. Our results showed that aspirin definitely blocked TAME-esterase induced contractions on rat aortic strips. In conclusion, the present work supported the hypothesis that [TAME]-esterase induced contraction in rat aorta in vitro was mediated through release of prostaglandin(s) as a result of endothelial dysfunction.
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PMID:Effects of aspirin on N-alpha-tosyl L-arginine methyl ester [TAME]-esterase induced contractions on rat aorta in vitro. 1258 32