Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0729233 (Thoracic)
 6,478 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thoracic duct lymphocytes (TDL) from C3H/Tif and BALB/c mice were studied for their in vitro reactivity to the B cell mitogens lipopolysaccharide (LPS) and lipoprotein (LP). Roughly 4% and 10% of the surface immunoglobulin (Ig)-positive cells in these populations could be stimulated by LPS and LP, respectively, to generate clones of IgM-secreting cells. Among LPS-reactive B cells, roughly 30% developed into clones which also produced IgG3 or IgG2, while only a very small fraction (1-2%) of all precursors could give rise to clones secreting IgG1 and IgA. Freshly collected TDL from some batches of C3H/HeJ mice displayed a high proportion of Ig-containing B cell blasts (5-10%), which did not secrete enough Ig to be detected as plaque-forming cells (PFC). These cells, however, under appropriate culture conditions and stimulated by LP (but not by Nocardia mitogen), differentiated to PFC of the various Ig classes without dividing.
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PMID:Characterization of mouse thoracic duct B lymphocytes. I. Evidence of functional heterogeneity. 700 May 21

The 29th President of the Society of Thoracic Surgeons, Benson R. Wilcox, MD, died at his home in Fearington Village Center, NC, on May 11, 2010. In 2 weeks, he would have been 78 years old, and the focus of a birthday celebration for his wife, Patsy Davis, his 4 children, Adelaide, Sandra, Melissa, and Reid, 11 grandchildren, and many loved ones. With his death, caused by brain cancer, the University of North Carolina lost one of its most prolific and loyal sons, and the profession of thoracic surgery, one of its wisest leaders. Two facts are certain: Ben will be remembered forever by his students, residents, and colleagues, and our sky is, indeed, Carolina blue.
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PMID:Benson R. Wilcox--industry, genius, judgment. 2073 54