Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0729233 (Thoracic)
 6,478 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The efficacy and toxicity of cisplatin/etoposide and carboplatin/etoposide combinations along with thoracic irradiation were prospectively assessed in patients with small cell lung cancer. Both combinations were equally effective. However, the carboplatin/etoposide regimen caused significantly less nausea, vomiting, nephrotoxicity, and neurotoxicity, and it was easier to administer. Dose intensity and treatment delays were similar in both groups. Thoracic irradiation given concurrently with chemotherapy is feasible and seems to offer a survival advantage. The relapse rate also is lower among patients who have received radiation therapy, and recurrences tended to be outside of the lung. Overall, a survival benefit was identified for patients aged between 50 and 65 years who had limited disease, good performance status, and only one metastatic site. Prophylactic brain irradiation in a subset of patients reduced brain metastasis, but the difference did not reach significance. From this trial, it is concluded that carboplatin/etoposide combination therapy is highly effective and is well tolerated by patients with small cell lung cancer. In limited disease, this combination can be given concurrently with thoracic irradiation and offers a survival advantage.
 ...
PMID:Cisplatin/etoposide versus carboplatin/etoposide chemotherapy and irradiation in small cell lung cancer: a randomized phase III study. Hellenic Cooperative Oncology Group for Lung Cancer Trials. 805 70

Small cell lung cancer comprises a histologic subgroup of bronchogenic carcinomas distinguished particularly by a responsiveness to cytotoxic agents, and equally by a strong tendency to disseminate, both to mediastinal and distant sites. At one time considered suitable only for short-term palliation by radiation therapy, this disease is now managed by both systemic and regional approaches, typically with close integration of radiotherapy and chemotherapy. Thoracic irradiation produces modest improvements in both survival and local control in small cell lung cancer, when the clinical extent is limited to the chest. The optimal parameters of dose, treatment volume, fractionation, and temporal integration with chemotherapy are not yet defined. When the disease is more extensive radiotherapy plays a useful palliative role. New biological insights are being brought to the clinic, and have stimulated new therapeutic initiatives in the treatment of this disease. Modified radiotherapy fractionation schemes and sophisticated integration of chemotherapy and radiation therapy have resulted in further advances. In addition to improved response rates and median survivals, combined modality approaches suggest, in addition, the possibility of cured subset in cases of disease confined to the chest. The adverse effects of thoracic irradiation are manageable and the more serious can be prevented with careful attention to volume and technique. Radiotherapy offers relief of many symptoms and cost-effective palliation of metastatic lesions in most body sites. Considered as a significant problem in oncology, and apart from efforts at primary prevention, major progress in this disease is most likely to result from research focussed on the limited disease subset, which, unfortunately, consists of no more than half the incident cases. These patients have a median survival of 12-18 months, and are sufficiently numerous that it is possible to detect meaningful treatment progress in clinical trials of a reasonable size. Nevertheless, the marked advances of two decades ago, when chemotherapy first came into widespread use, are not seen today. Progress is now more likely to be seen in modest improvements in survival or tumor control rates when control and experimental regimens are compared statistically in large trials or in meta-analyses. While the evidence supports the use of thoracic radiotherapy the ideal drug combination is unknown, and there is a real need for new agents of substantially greater activity than those available today. While more rational combinations of agents may be possible, it seems likely that the limits of tolerance are being reached.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:The role of radiation oncology in small cell lung cancer. 806 11

Thoracic oncology practice is changing with the end of the century. New diagnostic tools like photodetection allow to diagnose at a white light undetectable level. Preneoplastic lesions or very early cancers that can be locally treated by photochemotherapy, cryotherapy or brachytherapy. The natural history of lung cancer will also be better known. Concerning advanced disease, cisplatin chemotherapy improves survival of patients with stage III non-small cell lung cancer in combination with surgery or chest irradiation and of those with stage IV in comparison with best supportive care alone. New approaches in small cell lung cancer seem promising like accelerated chemotherapy, early chest radiotherapy and maintenance treatment. Moreover, a series of new active cytotoxic agents has been recently identified. The complexity of these modalities makes more and more necessary a integrated pluridisciplinary approach of the lung cancer patient.
 ...
PMID:[Current topics in pulmonary oncology]. 941 43

A combined modalities approach--radiotherapy plus chemotherapy to the treatment of limited small cell lung cancer are presented. There are three strategies for the treatment: sequential, concurrent and alternative therapy. Concurrent and alternative appear to be preferred. Thoracic radiotherapy can be administered continuously or "split course". There is a trend favouring the combination of Cisplatin + Vepeside as the chemotherapy regimen of choice in combined modality therapy for limited small cell lung cancer.
 ...
PMID:[Combined modalities in the treatment of limited small cell lung cancer]. 962 77

The incidence of elderly patients with small cell lung cancer is increasing in Japan. Because of the variation in their physical function and increasing co-morbid disease, elderly patients are usually excluded from clinical trials. Questionnaires were sent to 40 institutes of the "West Japan Thoracic Oncology Group", and answers from 33 (83%) institutes were obtained. Eighty-five percent of replies recognized the need of trials for limited disease (LD) and 70% for extensive disease (ED). We investigated the methods of staging procedures, and management of 351 small cell lung cancer patients aged 70 years or older diagnosed from 1994 to 1996 in 28 institutes. There were 173 patients aged 70-74, 120 aged 75-80, and 58 aged 80 years or older. Staging procedures including chest CT, abdominal CT, abdominal CT or Echo. Brain CT or MRI and bone scinti scan were performed in 333 (95%) patients. One hundred fifty-nine of 178 patients with LD and 143 of 168 patients with ED received anticancer therapy. Although 48% of PS 0-1 patients received 4 courses or more of chemotherapy, among the patients with ED 24% of patients with PS 2 and 19% of PS 3 patients received adequate chemotherapy. The response rate was 79% for LD and 69% for ED. Many elderly patients received insufficient courses and/or doses of chemotherapy but achieved a good response. Median survival for patients with LD and ED was 12 and 6 months, respectively. To determine suitable regimens for elderly patients with lung cancer, more clinical trials are definitely needed.
 ...
PMID:[How should we treat elderly patients with small cell lung cancer?--information gathered by questionnaires and analysis of 351 patients aged 70 or over. West Japan Thoracic Oncology Group]. 1041 Jan 49

Small cell lung cancer (SCLC) accounts for approximately 14% of all cases of lung cancer. Combination chemotherapy is the most effective treatment modality for SCLC and recently, several new active drugs have emerged. Combinations of platinum agents with CPT-11 or gemcitabine have been successfully compared in phase III trials against the cisplatin/etoposide standard. Modest improvements in the outcome of patients with SCLC have been noted over the last two decades. Thoracic irradiation given concurrently with chemotherapy improves survival compared with sequential chemotherapy and radiation, but this approach is associated with more toxicity. Moreover, the optimal doses and fractionation of thoracic irradiation remain to be determined. Three-dimensional treatment planning is under investigation. Prophylactic cranial irradiation (PCI) has established a role in the management of patients who have achieved a complete response to the initial therapy. Novel molecular targeted therapies are among the strategies currently being investigated in SCLC.
 ...
PMID:Progress in the therapy of small cell lung cancer. 1501 73

Small Cell Lung Cancer (SCLC) is highly sensitive to chemotherapy and radiotherapy. However, despite initial responses, relapses are common and most patients eventually succumb to this disease. Patients with limited-disease SCLC represent approximately 30% of all patients with SCLC, and are potentially curable when treated with combined chemotherapy and thoracic radiotherapy (TRT). Chemotherapy consists of four cycles of the combination of cisplatin and etoposide (PE). Thoracic radiotherapy should be started with the first or second cycle of chemotherapy, and preferably administered twice daily for 3 weeks. Prophylactic cranial irradiation (PCI) is recommended for patients who achieve a complete response. Surgery is of limited value in SCLC, except in patients who present with a solitary pulmonary nodule. Approximately 20% to 25% of patients with limited disease (LD)-SCLC can be cured with this aggressive approach. Newer treatment modalities are currently under investigation.
 ...
PMID:Combined modality therapy for limited-disease small cell lung cancer. 1561 Jul 16

Based on both clinical and laboratory data that suggested that tamoxifen (TAM) enhanced the effectiveness of cisplatin (DDP)-based chemotherapy regimens, the Cancer and Leukemia Group B (CALGB) designed and initiated a prospective, randomized phase III trial to test the efficacy of the addition of high-dose TAM to a standard chemoradiation regimen of DDP and etoposide (VP-16) in patients with limited-stage small cell lung cancer (LS-SCLC). Between August 6, 1993, and January 15, 1999, 319 patients with LSSCLC were accrued to CALGB 9235. Patients were randomized to receive chemotherapy with or without high-dose TAM. Treatment on the non-TAM containing arm (arm 1) included DDP (80 mg/m2 intravenously day 1 only) and VP-16 (80 mg/m2 intravenously days 1-3) given every 3 weeks for a total of 5 cycles. Patients treated on arm 2 received the identical chemotherapy regimen as described here with the addition of high-dose TAM (80 mg orally twice per day), which was given for 5 days each cycle starting 1 day before the DDP. Thoracic radiation (XRT) given at 200 cGy 5 days per week to a total dose of 50 Gy began on day 1 of cycle 4 of chemotherapy and overlapped with cycle 5. Prophylactic cranial irradiation was offered to all patients who achieved a complete response or near-complete response. A total of 307 patients are evaluable for response. After the completion of the chemoradiation portion of the treatment, the overall response rate (ORR) was 88% for 154 patients treated without tamoxifen and 84% for 153 patients treated with tamoxifen with complete response (CR) rates of 49% and 50%, respectively. The median failure-free survivals of 12.3 months and 10.5 months and the overall survivals of 20.6 months and 18.4 months, respectively, were not statistically significant between the 2 arms. Toxicity was similar with and without tamoxifen. This phase III trial failed to demonstrate a positive effect on either the response or survival for the addition of TAM to standard etoposide-cisplatin-radiation management for patients with LS-SCLC. However, these data continue to support a positive effect of chemoradiation in the treatment of patients with LS-SCLC.
 ...
PMID:A phase III trial evaluating the combination of cisplatin, etoposide, and radiation therapy with or without tamoxifen in patients with limited-stage small cell lung cancer: Cancer and Leukemia Group B Study (9235). 1568 40

Thoracic radiotherapy has an established role in the management of limited-disease small-cell lung cancer (LD SCLC). However, essential questions relating to the optimisation of thoracic radiotherapy remain unanswered, including volume of irradiation, optimal total dose, fractionation, timing and sequencing of radiation. This review highlights the need for well-designed multi-national trials aimed at the optimisation and standardisation of radiotherapy for LD SCLC.
 ...
PMID:Thoracic radiotherapy for limited-stage small-cell lung cancer: controversies and future developments. 1637 83

Radiotherapy is one of the main treatment modalities in lung cancer, contributing to both its cure and palliation. Thoracic irradiation has traditionally been considered the mainstay of treatment in inoperable stage III non-small cell lung cancer. However, despite technical developments and the addition of chemotherapy, the curative potential of radiotherapy in this subset of patients is disappointingly poor. The role of radiotherapy as an adjunct to pulmonary resection (preoperative and postoperative) is questionable, but well-designed and executed phase III studies are lacking. An important application of radiotherapy is palliation of tumor-related symptoms in the chest and in metastatic sites, such as bones and brain. In small cell lung cancer, routine applications of radiotherapy include chest radiotherapy in limited disease and prophylactic cranial irradiation in complete responders to chemotherapy, each increasing survival by about 5%.
 ...
PMID:The role of radiotherapy in lung cancer: where is the evidence? 1748 1


<< Previous 1 2 3 4 Next >>