Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0729233 (Thoracic)
 6,478 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Atypical mycobacterial infection mostly develops in the lung and its occurrence outside of the lung is very rare. We report a case of mycobacterium avium complex (MAC) infection found with chronic empyema piercing out of the thoracic wall, to which surgical treatment was very successful. A 72-year old male had been treated for an abscess of right thoracic wall. MAC was isolated from thoracic effusion. Thoracic window and pan-pleuro-pneumonectomy was performed. No recurrence of MAC infection was found up to 1 year and 4 months when he died of accident.
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PMID:[Surgical treatment of mycobacterium avium complex infection in a patient with chronic empyema]. 812 83

Described by Reich and Johnson in 1992 [2], the Lady Windermere syndrome occurs exclusively in non-smoking women over the age of 60 years, without significant pre-existing pulmonary disease. It comprises bronchial dilatation, typically in the middle lobe and lingula, together with secondary infection by atypical mycobacteria (Mycobacterium avium in the first cases). Among the 17 cases of atypical mycobacterial infection that we have seen in the past 14 years, there were seven cases of this syndrome. It was associated with cough, sputum, sometimes haemoptysis, febrile episodes and deterioration of general health. The diagnostic criteria and treatment were defined by the American Thoracic Society. The pathophysiological hypothesis proposed by Reich and Johnson was that voluntary suppression of the cough led to congestion of the bronchi and secondary infection with atypical mycobacteria. Currently it is thought more likely that the following factors are involved: progressive increase in dilatation of small bronchi, delayed diagnosis, morphological abnormalities of the thorax, hormonal factors, immune deficiency, genetic neutrophil dysfunction, and even heterozygous forms of cystic fibrosis.
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PMID:[The Lady Windermere syndrome: clinical and bacteriological data and progress in seven cases]. 2268 89