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The outcome of 48 pregnancies from 42 patients with systemic lupus erythematosus was studied. Their mean age and the duration of the disease were 28.47 and 4.42 years, respectively. The conception occurred when the disease was inactive or quiescent in 45 and active in 3. Four pregnancies were terminated by criminal abortion. Flares occurred in 16 pregnancies. The kidney and mucocutaneous system were the 2 organs that flared most commonly. The fetal outcomes were term delivery in 18 (40.90%), prematurity in 17 (38.64%), spontaneous abortion in 6 (13.64%) and still birth in 3 (6.82%). There was no statistical difference in pregnancy loss and successful delivery between pregnant patients with and without flares. Concerning 35 successful live births, those pregnancies without flares had significantly more full term deliveries (p < 0.02), higher gestational age (p < 0.002) and more birth weight (p < 0.001) than those with flares. Small for gestational age was seen in 20%. Pregnancy with active renal disease had a poor fetal outcome. There were no cases of congenital anomalies or neonatal lupus. Maternal complications were more common in patients with flares.
Asian Pac J Allergy Immunol 1999 Jun
PMID:Pregnancy outcome in Thai patients with systemic lupus erythematosus. 1046 42

An analysis of birth weight was undertaken on secondary data derived from the Malaysian Family Life Survey II. A total of 1629 last singleton live birth infants was analysed with the aim of identifying from the variables available potential risk factors for low birth weight. Univariate and subsequently multivariate analyses were carried out for this purpose. The incidence of low birth weight was 11.8 percent. Race, parity and prematurity were found to be significantly associated with low birth weight after controlling of the other variables. The findings indicate that more work needs to be done to establish the underlying reasons for low birth weight in Malaysia.
Asia Pac J Public Health 1999
PMID:Analysis of birth weight data from the Malaysian Family Life Survey II. 1119 61

PURPOSE. The pupose of this study was to compare maternal and paternal risk factors and the outcomes of Asian Pacific Islander (API) pregnancies with other racial/ethnic groups (Black, Hispanic, and White) in Illinois. METHODS. We examined computerized birth certificate files in Illinois to descriptively analyze birth outcomes and parental characteristics for births occurring between 1989 and 1993. Infant mortality tables were examined for birth cohorts born from 1989 to 1992. Rates among Illinois API groups were presented for the following: maternal and paternal socio-demographic factors; maternal medical risk factors, amount of prenatal care and type of method of delivery; newborn complications and various morbidity outcomes; and, early neonatal mortality. For comparison, simliar Illinois data are presented for Blacks and Whites and Hispanics. We statistically evaluated the significance in variability of rates. PRINCIPAL FINDINGS. APIs in Illinois experienced a lower infant mortality rate. API mothers were more likely to be married, beyond the teenage years, have more education and smoke less often during their pregnancy than any of the other racial/ethnic groups. In addition, API mothers were more likely to experience primiparity rather than high parity. We detected statistically signifacnt differences for maternal and paternal socio-demographic characteristics among the four populations (p<0.0001). Similarly we found statistically significant differences in risk factors during pregnancy and labor and delivery complications among four race/ethnic population (p<0.0001). CONCLUSIONS. Fetal, neonatal, post-natal and infant mortality rates were the lowest among APIs when compared to Hispanic, Black and White neonates. These differences were statistically signifacant. However, rates of inadequate prenatal care, labor and elivery complications, prematurity and low birth weight were not similarly lower among APIs. RELEVANCE TO ASIAN AND PACIFIC ISLANDER AMERICAN POPULATIONS. This paper provides a state-level examination of parental risk factors and birth outcomes among APIs. KEY WORDS. infant mortality rates; pregnancy outcomes; prenatal care; maternal risk factors; paternal risk factors; women; Illinois.
Asian Am Pac Isl J Health 1995
PMID:Maternal and Paternal Risk Factors and Birth Outcomes among Asian and Pacific Islanders in Illinois. 1156 95

Many disorders that affect the brain can cause shape changes in subcortical structures, and these may provide biomarkers for disease detection and progression. Automatic tools are needed to accurately identify and characterize these alterations. In recent work, we developed a surface multivariate tensor-based morphometry analysis (mTBM) to detect morphological group differences in subcortical structures, and we applied this method to study HIV/AIDS, William's syndrome, Alzheimer's disease and prematurity. Here we will focus more specifically on mTBM in neonates, which, in its current form, starts with manually segmented subcortical structures from MRI images of a two subject groups, places a conformal grid on each of their surfaces, registers them to a template through a constrained harmonic map and provides statistical comparisons between the two groups, at each vertex of the template grid. We improve this pipeline in two ways: first by replacing the constrained harmonic map with a new fluid registration algorithm that we recently developed. Secondly, by optimizing the pipeline to study the putamen in newborns. Our analysis is applied to the comparison of the putamen in premature and term born neonates. Recent whole-brain volumetric studies have detected differences in this structure in babies born preterm. Here we add to the literature on this topic by zooming in on this structure, and by generating the first surface-based maps of these changes. To do so, we use a dataset of manually segmented putamens from T1-weighted brain MR images from 17 preterm and 18 term-born neonates. Statistical comparisons between the two groups are performed via four methods: univariate and multivariate tensor-based morphometry, the commonly used medial axis distance, and a combination of the last two statistics. We detect widespread statistically significant differences in morphology between the two groups that are consistent across statistics, but more extensive for multivariate measures.
Signal Inf Process Assoc Annu Summit Conf APSIPA Asia Pac 2012 Dec
PMID:Surface fluid registration and multivariate tensor-based morphometry in newborns - the effects of prematurity on the putamen. 2993 10