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Query: UMLS:C0728731 (prematurity)
 7,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Isolated dog hearts perfused with blood from a donor dogand driven at two heart rates were used to compare the effects of propranolol with those of its quaternary ammonium derivative on atrial, atrioventricular (AV) nodal, and His-Purkinje conduction. Propranolol slowed only AV-nodal conduction, increasing the minimal conduction time and the effect of prematurity, without affecting fatigue. Practolol did not have this effect. Dimethylpropranolol had similar but not identical effects on the AV node, but also slowed atrial and ventricular conduction. In contrast with the quaternary derivative of lidocaine, dimethylpropranolol's effect on atrial and ventricular conduction was not dependent on the heart rate. The effect of dimethylpropranolol on ventricular conduction was observed at doses lower than those reported by others to be antiarrhythmic.
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PMID:The effect of propranolol and dimethylpropranolol on cardiac conduction. 48 71

The effects of lidocaine and methyl lidocaine on cardiac conduction were studied using His bundle recordings from isolated blood perfused dog hearts. The input and output characteristic of the atrioventricular (AV) node can be described as consisting of three components, namely, minimal conduction time, fatigue, and the effect of prematurity (deltaCT). Lidocaine (2.5-10.0 mg/kg) increased minimal conduction time but not fatigue. Methyl lidocaine (1.25-5.0 mg/kg) increased both. A dose of 5 mg/kg or less of either drug caused a nonparallel shift of the deltaCT curve to the right. High doses of lidocaine (10 mg/kg) cause deltaCT to become rate-dependent. Lidocaine slowed atrial conduction only slightly. Atrial block prevented the observation of the effect of methyl lidocaine in doses higher than 5.0 mg/kg. Both drugs showed greater effect on atrial conduction at fast heart rate. Lidocaine did not affect ventricular conduction time at slow heart rates and had only minimal effects at fast heart rates. Methyl lidocaine increased ventricular conduction time at all heart rates. The results of this study indicate that lidocaine and methyl lidocaine have entirely different spectra of activity on cardiac conduction, in that their effect on AV nodal conduction do not differ greatly whereas the quaternary analog has a much stronger depressant effect on atrial and ventricular conduction.
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PMID:Effect of lidocaine and methyl lidocaine on cardiac conduction. 85 Jan 38

Since the obstetrician has the first opportunity to influence the mother, he should be knowledgeable about breast-feeding. Prenatal preparation, discussion of fears and anxieties, and the provision of literature are outlined as elements of successful nursing. The anatomy and physiology of nursing include a discussion in lay terms of milk production and milk ejection (let down), nipple examination, nursing posture, simulated nursing technique, breast massage and manual expression. Elements of nursing during hospital stay discussed are parturition, the nursing staff, jack-nifing the infant in preparation for feeding, breaking suction, feeding schedule, milk tension, foremilk, ejection reflex and the formation of hindmilk, aids in milk ejection, frequency and length of feedings, the use of both breasts, the draught, demand feeding and rooming in, dehydration, brassiere, uterine cramps, sore nipples, prematurity, cesarean section, and multiple births. Infant requirements, jaundice, postpartum examination, stools, colic, rashes, medication, contraception, bottle-feeding, maternal diet, fatigue and stress, leaking, the working mother, solid foods, breast infection and weaning are discussed as a part of the posthospital period.
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PMID:The obstetrician's approach to the breasts and breastfeeding. 112 77

In a recent report on prematurity and work in pregnancy based on the Montreal survey noteworthy increases in both preterm births (less than 37 weeks) and infants of low birth weight (less than or equal to 2500 g) were found in women in certain specific occupations or whose work entailed heavy lifting, shift work, long hours, or great fatigue. Because of the large overlap between preterm births and low birth weight, the latter was further analysed with allowance for gestational age in order better to separate factors retarding fetal growth from those shortening gestation. The association of low birth weight with specific occupations, long working hours, and fatigue largely disappeared, suggesting that the effect of these factors was to shorten gestation. By contrast, the association with lifting heavy weights and with shift work persisted, suggesting that these factors retarded fetal growth as well as increasing the risk of preterm birth.
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PMID:Work in pregnancy and birth weight for gestational age. 293 Jul 30

Illness associated adenovirus infection is described in 15 immunocompromised patients. Patients were immunocompromised by severe underlying disease, immunosuppressive or corticosteroid therapy or by age (prematurity). Evidence of adenovirus infection was obtained by either viral isolation or, in two cases, characteristic adenovirus inclusion bodies at postmortem study. All clinical illness was associated with high fever (temperature greater than 39 degrees C). Eighty per cent of the patients had severe systemic complaints including malaise, lethargy, fatigue and night sweats; a similar number of gastrointestinal symptoms. Pulmonary complaints were described in 11 of 15 cases and included cough (67 per cent) and tachypnea (53 per cent). Roentgenologic evidence of pneumonia was demonstrated in 12 of 15 patients (80 per cent). Elevation of serum hepatic enzyme levels (serum glutamic pyruvic transaminase (SGPT)) occurred in eight of 11 patients (73 per cent) and was moderate to severe (serum glutamic pyruvic transaminase greater than 450 IU/liter) in five of 11 (45 per cent). Nine patients died; seven after a rapid downhill course and two after a prolonged illness. Evidence of adenovirus infection microscopically by autopsy in the lung, liver or both is demonstrated in four patients with fulminant systemic illness. Adenovirus infection should be considered in the etiology of severe overwhelming illness in the immunocompromised host.
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PMID:Adenovirus infection in the immunocompromised patient. 624 99

The aim of this study was to determine the elements of fatigue in occupations which constitute possible risk factors for the course of a pregnancy, and, in particular, that could cause premature birth. In 1977-1978, a total of 3437 women in France were surveyed after giving birth in two maternity hospitals. One hospital was located in Lyon (a large city) and the other in Haguenau (a small town). Among 1928 working women, it was found that certain occupational categories are more prone to risk of prematurity than others. The authors carried out an analytical breakdown of the job into its diverse components which led them to define five sources of fatigue and to construct an index capable of detecting the strenuous working conditions. There is a significant relationship between the prematurity rate and the number of high fatigue scores observed in the job. When the number of scores varies from 0 to 5 the rate of premature births increases from 2.3% to 11.1%. This relationship remains significant after controlling for confounding factors.
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PMID:Prematurity and occupational activity during pregnancy. 670 9

Premature delivery is defined as birth between 22 and 37 weeks of pregnancy. Perinatal mortality and morbidity and their sequellae are strongly linked to gestational age. Minimum prematurity is around 3% of births. Medical risks of premature birth should be detected outside of pregnancy (uterine) or during pregnancy, at the first outpatient visit, the critical moment for establishing factors of risk. Preventive measures include awakening women to their responsibility, before and during pregnancy, and suppressing toxic agents (tobacco and alcohol). Treatment of medical causes of preterm birth is more effective if accompanied by measures acting on the environment, such as rest adapted to fatigue, improved environmental conditions, decentralisation and local situation of medical follow-up and social assistance, hospitalisation at home, telesurveillance and, in severe cases, total hospital rest (for which alternatives such as family hotels should be sought). Every element of the existing structures should be used complementarily.
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PMID:[Prevention of prematurity]. 749 58

Theophylline alleviates central and obstructive apneas of prematurity, and may improve adult obstructive sleep apnea. One mechanism of action appears to be a stimulatory effect on the motor output to upper airway dilator muscles. The purpose of the present study was to determine whether theophylline might have a second mechanism of action, namely that of improving the force and/or endurance of the pharyngeal dilator musculature. Rat sternohyoid muscle strips were studied in vitro and compared to diaphragm strips. The isometric twitch force and twitch kinetics of neither muscle were altered by theophylline (100 mg/l). Theophylline significantly slowed the rate at which the diaphragm fatigued during intermittent 40-Hz stimulation (p < 0.001). In contrast, theophylline produced no improvement in the fatigue resistance of the sternohyoid muscle. The degree of force potentiation during the early portion of the fatigue protocol was not altered by theophylline for either muscle. These results suggest that the mechanism by which theophylline improves obstructive apnea is unlikely to be due to a beneficial effect on pharyngeal dilator muscle force or endurance.
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PMID:Effects of theophylline on pharyngeal dilator and diaphragm muscle contractile properties. 896 72

Conditions leading to chronic pulmonary insufficiency can affect infants and children. These can lead to growth failure and delayed development. Among the most common and severe of these are bronchopulmonary dysplasia (BPD) and cystic fibrosis. In addition to the respiratory consequences of these diseases, there is ample evidence that they lead to decreased growth as a result of decreased energy intake and increased energy expenditure. Furthermore, there is evidence that infants with BPD may also have delayed development, independent of the effects of their prematurity. Enhancing the long-term outlook for these conditions may therefore require consideration of both improved pulmonary management and aggressive nutritional management to limit growth failure and potentially enhance developmental outcome. Specific micronutrient supplementation, such as antioxidant therapy, may also enhance pulmonary and nutritional status.
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PMID:Chronic pulmonary insufficiency in children and its effects on growth and development. 1123 90

Dietary deficiency in iron and to a lesser extent folic acid is the principle cause of anemia in the world. Reproductive aged women and growing children are the principle groups at risk of anemia. About half of nonpregnant reproductive aged women in tropical countries have hemoglobin levels lower than 12 g/100 ml, the level used by the World Health Organization to define anemia. Nutritional anemia is even more widespread among pregnant and lactating women because of the increased needs for iron during those periods. Pregnant women need almost 500 mg of iron for their increased red blood cell mass, 220 mg for routine iron loss through the urine, bile, sweat, and other routes; 290 mg for the fetus, and almost 25 mg for the placenta. In all, the pregnant women theoretically requires over 1000 mg of iron through diet or bodily reserves. Healthy, well-nourished women have total iron reserves of 2500 mg, but according to published data almost 2/3 of pregnant women even in favorable circumstances end their pregnancies with no remaining iron reserves. In tropical regions the lack of iron reserves is aggravated by parasites and infections, closely spaced pregnancies that do not allow restoration of reserves, and poor dietary availability of iron. Anemia during pregnancy is associated with elevated risks of maternal morbidity and mortality. Fatigue, dyspnea, palpitations and tachycardia, vertigo, loss of appetite and cravings for soil or other inappropriate substances are frequently observed in anemic women. The risks of prematurity and low weight are increased for infants of anemic women. Fetal malformation may be associated with folic acid deficiency. Nutrition education is needed for pregnant women. Local foods may be enriched with iron, and pregnant women may be given iron and vitamin B12 supplements directly. Iron supplements may rapidly increase iron reserves, but they are poorly tolerated by many women. The supplements should be avoided if possible early in the pregnancy because digestive intolerance is more likely in the 1st months of pregnancy. Parasitic and bacterial infections should be diagnosed and treated as a step in controlling anemia.
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PMID:[Impact of nutritional deficiencies on anemia in pregnant women]. 1228 20


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