Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0728731 (prematurity)
 7,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 2,948-g full-term male infant, the product of an uncomplicated pregnancy, developed fundus changes consistent with retrolental fibroplasia in the absence of supplemental oxygen therapy. He had no associated illnesses or congenital anomalies, and had not received exchange transfusions. There was no family history of ocular disease. Changes similar to those of retrolental fibroplasia do occasionally occur in fullterm infants who have had no supplemental oxygen therapy. A relative hyperoxia caused by the increase in arterial oxygen saturation occurring at birth is one possible explanation for these events. This rise, plus susceptibility factors apart from prematurity, may account for these unusual cases. Additionally, these cases may represent sporadic examples of familial exudative vitreoretinopathy.
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PMID:Peripheral proliferative retinopathy without oxygen therapy in a full-term infant. 689 16

The effect of blood transfusion on the occurrence of RLF was evaluated in 58 infants who weighed less than 1001 g at birth (Group I) and 70 oxygen treated infants of various birth weights (Group II). Although there was no significant difference between Group I infants with or without exchange transfusion as to birth weight, gestational age, duration of oxygen therapy, peak Pa02's, or multiple births, there was a significantly increased incidence of pre-retrolental fibroplasia in transfused over non-transfused Group II infants. When Group II infants were stratified for prematurity and oxygen duration, this difference persisted in those not already at risk for RLF. This increased incidence of retinopathy in transfused infants suggests that blood transfusion may be a risk factor in the pathogenesis of RLF.
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PMID:Blood transfusion: a possible risk factor in retrolental fibroplasia. 689 73

Between July, 1977, and December, 1979, a total of 699 babies was screened in special care nurseries for retrolental fibroplasia (RLF). Changes were found in 46 babies (6.6%): in 25 of these, RLF reached only Stage I or Stage II of the Keith classification, and later regressed completely. The remaining 21 reached Stage III or higher and in 25% the condition progressed to permanent visual damage. Retrolental fibroplasia did not occur in babies whose highest PaO2 did not exceed 10.7 kPa (80 mmHg), and in babies who had less then three days of oxygen therapy. It did not reach Stage III in babies who weighed more than 1600 g at birth or were of more than 32 weeks' gestation. Girls were significantly more affected than boys. This study supports the strict correlation of RLF with prematurity and oxygen therapy; we found retrolental fibroplasia only in the very small and very premature infants, and visual damage only occurred in approximately 5% of these.
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PMID:Retrolental fibroplasia: a study of the incidence and aetiological factors, 1977-1979. 689 27

Re-examination of corrected visual acuity was done in 137 18-year-old Danes, who were originally examined at the age of 10 years, as part of a study of sequels to low birth weight (LBW) (Fledelius 1976). Median values indicate that most adolescents are able visually to discriminate considerably above the customary 6/6 limit. As compared with low-birth-weighters (n=70), full-terms (n=67) show a significantly higher cumulated visual acuity score. Similarly, binocular median visual acuities are 1.2 (LBW) and 1.4 (in FT). The difference is neither explained by the ex-prematures' higher frequency of heterotropia, nor by their (minor) share of eyes with subnormal vision. The latter occurred especially in the subgroup of 'myopia of prematurity'. The exceptional cases with RLF-blindness were discarded from follow-up. Concerning visual acuity, the previously reported lagging behind of ex-prematures in childhood has proven to be not only a temporary delay, but a permanent (adult) feature.
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PMID:Ophthalmic changes from age of 10 to 18 years. A longitudinal study of sequels to low birth weight. II. Visual acuity. 721 Dec 84

A review of infants with respiratory distress born at the Mercy Maternity Hospital, Melbourne, during the years from 1975 to 1977 showed that live-born infants totalled 13304; 288 (2.2%) had respiratory distress. Of the 13304 infants, 197 died; 75 (38.1%) were infants with respiratory distress. Hyaline membrane disease was the cause of the respiratory distress in 153 (53.1%) infants; 58 (37.9%) infants with that problem died. Hyaline membrane disease accounted for 58 (77.3%) of the 75 deaths in infants with respiratory distress. Assisted ventilation was required in 147 (51.0%) infants with respiratory distress and chronic complications of its use acceptable as bronchopulmonary dysplasia occurred in only 8.2% and retrolental fibroplasia in only 3.4%; it is suggested that assisted ventilation was commenced too late in 23 (34.0%) infants. Twenty-eight (42.0%) infants with respiratory distress died despite correct usage of assisted ventilation. This number attests to the dangers of prematurity; hence the decision to deliver an infant prematurely should not be taken lightly.
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PMID:Respiratory distress in newborn infants: contribution to current mortality. 725 33

Synthetic surfactant has been shown to reduce neonatal and 1-year mortality and neonatal morbidity in infants with respiratory distress syndrome. However, less is known about the effects of synthetic surfactant on developmental outcome and long-term morbidity. Four multicenter, randomized, placebo-controlled trials of synthetic surfactant administered as rescue therapy were conducted in the United States and Canada, with a total enrollment of 2224 patients. Double-blind developmental evaluations of survivors were conducted at 1 year of age (adjusted for prematurity) in all four trials. Of the 1802 patients enrolled in the placebo-controlled rescue trials who survived to 1 year, 1540 (85%) completed the 1-year follow-up evaluation. Height, weight, and head circumference measurements were not different in the treatment and control groups. Mean and median Bayley Scores of Infant Development for both the Mental Development Index and the Psychomotor Development Index were also equivalent. The incidence of impairments was not different in the two groups (mild to moderate impairment, 12% (92 of 745) for the air placebo group vs 11% (86 of 771) for the synthetic surfactant group; severe impairment, 15% (114 of 745) for the air placebo group vs 13% (102 of 771) for the synthetic surfactant group). No differences in rates of retinopathy of prematurity or hearing impairment were found in the treatment groups. The need for surgery after day 28 of life (relative risk, 0.779; 95% confidence interval, 0.665, 0.927) and the need for respiratory support at 1 year (relative risk, 0.525; 95% confidence intervals, 0.303, 0.911) were both reduced in the synthetic surfactant group. These results indicate that developmental outcome at 1 year of age is at least as good among infants with respiratory distress syndrome who received rescue therapy with synthetic surfactant as it is in infants who received air placebo; the results also indicate that the incidence of long-term morbidity is reduced.
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PMID:Double-blind 1-year follow-up of 1540 infants with respiratory distress syndrome randomized to rescue treatment with two doses of synthetic surfactant or air in four clinical trials. American and Canadian Exosurf Neonatal Study Groups. 774 10

More and more authors point out the existence of the retinal folds at the prematures with retrolental fibroplasia. This form is considered to be achieved. The survey has been done during 3 years on 27 children, divided in 2 groups: the former was the group of the prematures with retinal fold present in retrolental fibroplasia, and the later was the group of children with congenital retinal fold, but born at time. Clinically, the difference between the two types of folds is not so obvious, but from the morphoscopical aspect they differ. The therapy of the diagnosed children was the usual one done in complications: strabismus, cataract, retinal detachment. The conclusions is that, besides the malformative retinal fold of the child born at time, another similar lesion provoked by the prematurity and abusive oxygenation is possible.
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PMID:[The retinal fold in premature infants]. 776 80

Ultrasound axial length measurements were obtained on infants under a birthweight of 1500 g or 32 weeks gestation undergoing screening for retinopathy of prematurity (ROP). A total of 496 readings were obtained on 171 infants between 32 and 41 weeks post-conceptual age. Other details recorded were maximum stage of acute ROP, birthweight, gestational age, sex, and biparietal and occipitofrontal head diameters. The relationship of these variables to axial growth of the eye was examined using analysis of covariance with a repeated measures approach. Mean axial length increased from 15.27 mm to 16.65 mm in the left eye during this period. Following adjustment for repeated readings a growth rate of 0.18 mm/week was obtained for both eyes. Male infants were found to have longer axial lengths despite correction for birthweight, gestation and head size (p < 0.0001 right and left). Higher stages of acute ROP were also associated with shorter axial length (p < 0.05 for all stages of both eyes) but the rate of growth during the study period did not demonstrate significant differences between stages. Stage 3 infants reaching the threshold for cryotherapy had shorter axial length than stage 3 infants not receiving treatment. The effect of prematurity on the growth of the eye and the significance of these findings with respect to the subsequent development of refractive errors in premature infants are discussed.
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PMID:Axial length biometry in infants with retinopathy of prematurity. 782 66

83 infants born before 34 weeks of gestation between 1989 and 1990 and cared for at a neonatal intensive care unit in Kuopio, Finland, were screened for congenital cytomegalovirus (CMV) infection, defined as a positive culture from the sample of urine taken on the first day after birth. Four infants were infected and excreted CMV in the urine. The overall incidence of CMV excretors was 4.8%. The incidence was 1/13 infants born before 28 weeks' gestation and 3/70 infants born between 28 and 34 weeks of gestation. The 4 CMV excretors were followed up for 12-25 months. Two children had normal psychomotor and mental development but exhibited decreasing head growth during follow-up. The other 2 developed severe psychomotor retardation, retinopathy of prematurity, chorioretinitis, and microcephaly. The long-term morbidity was associated not only with congenital CMV infection but to prematurity as well. The incidence of congenital CMV excretors in this preterm population seemed to be higher than reported previously among unselected live-born infants. Early diagnosis of congenital CMV infection would seem to be important in view of forthcoming new therapeutic regimes in the near future.
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PMID:Screening for congenital cytomegalovirus infection among preterm infants born before the 34th gestational week in Finland. 798 66

Myopia is a frequent finding in preterm children. The close association between myopia and retinopathy of prematurity (ROP) suggested a causal relationship, but myopia of prematurity without ROP has yet to be explained. An alternative explanation is presented: myopia is caused by postnatal ellipsoid deformation of the spheric eyeball, i.e. excessive elongation of the optical, as a result of a dolichocephalic deformation of the skull with a short frontal axis. This deformation of the skull is the direct result of bone mineral deficiency frequently observed in very low birth weight infants with increasing postnatal age. This hypothesis is supported by the results of a historical comparison of very low birth weight infants without and with supplementation with calcium and phosphorus that was given in order to prevent postnatal bone mineral deficiency. In the unsupplemented group 4 of 23 children (61%) needed spectacles but only 6 out of 55 (11%) children who were supplemented as babies (questionnaire). Refraction measurements showed myopia stronger than -1 o.d. in group 1 in 5 of 14 infants, whereas in group 2 only 2 out of 22 infants were myopic (P < 0.05).
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PMID:Hypothesis: myopia of prematurity is caused by postnatal bone mineral deficiency. 775 30


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