Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0728731 (prematurity)
 7,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Miscarrying of pregnancy remains a major problem in obstetrics and gynecology. Inflammatory disease is known to affect reproductive function. To identify the role of the urogenital infection in the genesis of miscarriage, 58 women with complicated obstetrical anamnesis are examined. It is found that the persisting sexually transmitted urogenital infection plays a leading role in the genesis of miscarrying. The way of treatment for imminent abortion which significantly increases (70-90%) the rate of full term viable babies in women with habitual noncarrying of pregnancy is offered. Prophylactic measures aimed at against placental insufficiency in early period of pregnancy are proposed. Of a special importance is the prenatal observation, timely diagnostics and correction of disorders in order to prevent imminent abortion, habitual abortion and prematurity or too early birth.
 ...
PMID:Diagnostic indices of fetoplacental complex in pregnancy assessment of women with genital infections. 1907 37

Obstetric complications are the hallmark of antiphospholipid syndrome. Recurrent miscarriage, early delivery, oligohydramnios, prematurity, intrauterine growth restriction, fetal distress, fetal or neonatal thrombosis, pre-eclampsia/eclampsia, HELLP syndrome, arterial or venous thrombosis and placental insufficiency are the most severe APS-related complication for pregnant women. Antiphospholipid antibodies promote activation of endothelial cells, monocytes and platelets, causing an overproduction of tissue factor and thromboxane A2. Complement activation might have a central pathogenetic role. These factors, associated with the typical changes in the hemostatic system during normal pregnancy, result in a hypercoagulable state. This is responsible of thrombosis that is presumed to provoke many of the pregnancy complications associated with APS. Obstetric care is based on combined medical-obstetric high-risk management and treatment with the association between aspirin and heparin. This review aims to deter- mine the current state of the art of APS by investigating the knowledge achievements of recent years, to provide the most appropriate diagnostic and therapeutic management for pregnant women suffering from this syndrome.
 ...
PMID:Antiphospholipid Syndrome during pregnancy: the state of the art. 2243 75