Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0728731 (prematurity)
 7,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Post-perinatal infant mortality (PPIM; deaths from the 8th day to the end of the 1st year of life) was studied in Glasgow over the 3-year period 1979-81. The 244 deaths were divided into three main categories--those determined at birth, those due to accidents and acquired disease, and cot deaths. 50% of deaths were determined at birth, and of these 46% were due to prematurity and 49% to congenital disorder. Cot deaths accounted for 44% of the total (88% of deaths not determined at birth) and a definite cause could be identified in only 10% of these. The PPIM rate was 6.1 per 1000 livebirths, a significant part of the infant mortality rate of 12.6. The significance of these findings is discussed in relation to the possible reduction of these figures.
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PMID:Post-perinatal infant mortality in Glasgow 1979-81. 612 86

Twenty-four fatal cases of echo 11 infection in the eleven years 1968-78 are presented. All were children, and could be divided into two groups according to age at death and clinical presentation. The first group comprised 12 babies who died aged between 5 and 11 days after a short illness characterised by collapse, acidosis, and bleeding. At necropsy there was evidence of disseminated intravascular coagulation with haemorrhage into many organs including the renal medulla, suprarenal glands, gastrointestinal tract, and central nervous system. Six cases showed hepatic necrosis which was massive in three. Virus was present in many tissues. Infection was probably acquired from the mothers at delivery in 3 cases. Low maternal neutralising antibody titres and prematurity were thought to be adverse factors in the outcome. The second group consisted of 12 children aged between 9 weeks and 4 years 10 months who died suddenly. Pathological findings included upper respiratory tract infection, pneumonia, encephalitis, and gastroenteritis. Six of this group had been classified as 'cot deaths'. The role of echo 11 in the death of some of these older children is unknown. This report shows the danger of echo 11 to neonates, especially if unprotected by maternal antibody.
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PMID:Fatal infection with echovirus 11. 719 96

Neonates are at a high risk of temperature loss. Those born at less than 30 weeks' gestation should be placed in a plastic bag or wrapped immediately at birth, drying the head and putting on a hat, while maintaining routine precautions, such as warming the delivery room, pre-warming surfaces and eliminating draughts. Environmental humidity greater than 50 per cent is required, with up to 85 per cent for extreme prematurity, subject to individual assessment. Using regular or, ideally, continuous monitoring, the child's central (core) body temperature should be maintained at 36.7-37.3 degrees C with a core-peripheral difference, if measured, of 0.5-1 degrees C. Stabilised newborns can be transferred from an incubator into an unheated bassinet or open cot at an optimum weight of > 1.6kg, however individual assessment of each neonate is essential before transferring out of the incubator. In the absence of sufficient research, fully evidence-based recommendations cannot be made and individual unit protocols should be followed with careful clinical judgement. In resource-limited settings--in developing countries around the globe, for example--staff should be trained in simple resuscitation techniques, with keeping newborns warm as a key objective.
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PMID:Evidence-based thermal care of low birthweight neonates. Part one. 2358 79