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Query: UMLS:C0700208 (scoliosis)
 8,574 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The natural history, associated anomalies, and response to operative and nonoperative treatment were reviewed in 102 patients with neurofibromatosis and spine deformity. Eighty patients were found to have curvatures associated with dystrophic changes in the vertebrae and ribs. The presence of dystrophic changes such as rib penciling, spindling of the transverse processes, vertebral scalloping, severe apical vertebral rotation, foraminal enlargement, and adjacent soft-tissue neurofibromas was found to be highly significant in prognosis and management. Brace treatment of dystrophic curves was unsuccessful. Posterior fusion, with or without internal fixation, was the procedure of choice for problems due purely to scoliosis. Patients with dystrophic kyphoscoliosis required both anterior and posterior fusion to achieve stability. Sixteen patients had compression of the spinal cord or cauda equina.
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PMID:Spine deformity in neurofibromatosis. A review of one hundred and two patients. 11 Aug 13

Fifty-six patients with neurofibromatosis were examined for abnormalities of the cervical spine and seventeen of them had demonstrated lesions there. Of the thirty-four patients who had scoliosis or kyphoscoliosis, fifteen (44 per cent) had cervical lesions. Many of the patients with those lesions were asymptomatic. To avoid the complications attributable to the cervical spine, we recommend roentgenographic examination in all neurofibromatosis patients who are about to have general anesthesia or skull traction for treatment of scoliosis.
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PMID:Cervical spine abnormalities in neurofibromatosis. 11 Aug 14

A case of neurofibromatosis in a 7-year-old boy from Greenland is presented. The patient suddenly developed a severe thoracic scoliosis because of a total luxation of the upper thoracic vertebrae caused by erosion from soft tissue tumours in the region. Tomography revealed the bone changes, and CT whole-body scanning showed the extent of the soft tissue tumours and also the destruction of the vertebrae. The diagnosis was verified by biopsy.
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PMID:A case of neurofibromatosis with severe osseous disease of the thoracic spine. 11 20

Scoliosis is a complication of spinal lesions in neurofibromatosis, and leads frequently to major deformities with dislocations. The authors conducted a critical study of 31 cases surgically treated during the 1954-73 period of time. The techniques of spine straightening and of arthrodesis were recalled. The authors conclude that in case of moderate deformity (less than 100 degrees) Harrington's operation was satisfactory enough when correctly conducted. In case of severe dislocation and kyphosis, straightening was obtained after long lasting casts and halo tractions. Then posterior fusion using Harrington's rods had usually to be completed by anterior, transthoracic fusion for better solidity.
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PMID:[Critical evaluation of the surgical treatment of vertebral lesions due to neurofibromatosis. 31 cases (1954-1973)]. 12 68

A case of an intrathoracic meningocele associated with vertebral scalloping, enlarged intervertebral foramina and scoliosis in neurofibromatosis without spinal or nerve root rumors is described. A markedly attenuated dura mater anteriorly was present at autopsy and may have predisposed to meningeal herniation and scalloping.
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PMID:Intrathoracic meningocele and vertebral anomalies in a case of neurofibromatosis. 41 67

A case is reported of spontaneous rupture of an intercostal artery at its origin from the aorta in a patient with neurofibromatosis and scoliosis. The possible role played by each of these conditions in the pathogenesis of the spontaneous rupture is discussed. Comment is made on the unusual radiologic appearances of extrapleural hemorrhage.
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PMID:Spotaneous rupture of an intercostal artery in a patient with neurofibromatosis and scoliosis. 80 84

Preoperative correction of scoliotic curves by traction and casting improves the results achieved by operation. Use of the halo-hoop apparatus allows controlled correction when combined with spinal osteotomies. The anterior approach to the spine allows better correction and fusion of the more difficult curves of congenital scoliosis and those associated with neurofibromatosis and myelomeningocele.
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PMID:New technics in the operative treatment of scoliosis. 81 82

Of 400 patients with the diagnosis of neurofibromatosis on their hospital records, 141 actually had the disease. The presence of at least two of the following features was considered diagnostic: positive family history; positive biopsy; a minimum of six cafe-au-lait spots, each with a diameter of at least 1.5 centimeters; and multiple subcutaneous neurofibromas. Scoliosis was present in thirty-seven patients (26 per cent), most commonly associated with cafe-au-lait spots (thirty-five patients). In many of the patients with scoliosis there were associated medical and surgical problems. Although no standard pattern of spinal deformity could be identified, a sharp single right thoracic curve involving more than five vertebrae was the most common. For the whole group the initial measurement of the scoliosis averaged 42 degrees. Double curves were more sever, buth kyphosis was uncommon and no cases of paraplegia were recorded. In patients with progressive scoliosis, the best results were obtained with early Harrington instrumentation and posterior spine fusion. Progression of the scoliosis was observed both before treatment and postoperatively. The amount of progression was not necessarily related to the severity of other manifestations of neurofibromatosis, and was not significantly dependent on the length of the curve.
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PMID:Neurofibromatous scoliosis. Natural history and results of treatment in thirty-seven cases. 81 47

Scoliosis, in particular kyphoscoliosis, is the most frequent bony abnormality in neurofibromatosis (up to 43 per cent). The most usually accepted aetiopathogenesis is a primary mesoblastic defect of the vertebrae, though other hypotheses exist. Hereditary factors have been shown to be present in about half the cases and the spinal deformity is almost always associated with skin changes, and less frequently with nerve or cardiac changes or with elefantiasis. The ages most affected are from four to eleven years, the commonest site is the dorsal spine and the average number of affected vertebrae is 5.5. There are three main radiological characteristics: widening of the spinal canal, widening of the intervertebral foraminae, and a scalloped appearance of the posterior borders of the vertebral bodies. From the point of view of prognisis the scoliosis is markedly progressive and difficult to control, even after bone maturity. In consequence, neurological symptoms frequently arise, usually as late complications.
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PMID:Deformities of the spine in neurofibromatosis. Clinical and radiographic study of 46 cases. 82 27

Cobb in 1950 stated that a high proportion of scolioses, classified as idiopathic, may be due to neurofibromatosis. This paper describes a retrospective study of a series of 3209 scoliosis cases to determine the incidence of neurofibromatosis. It was found to be just over 3 per cent. Two different clinical pictures of scoliosis were seen among the neurofibromatosis cases.
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PMID:The incidence of scoliosis due to neurofibromatosis. 82 4


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