Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0700208 (scoliosis)
 8,574 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

With a rate of 0.5-1/1,000 of the total number of births in West Germany, spina bifida is next to cerebral paresis one of the most frequent congenital defects. Altogether, fifty places in special schools are needed per one million of inhabitants for spina bifida children. The loss of physical unctions is comparable to that in the case of paraplegia. The variety of medical and psychological problems makes the cooperation of highly different branches of study indispensible in a rehabilitation team (neurosurgeon, neuropediatrician, urologist, orthopaedist, pediatrician, educator, social worker, physical therapist). Each team member must be informed about the complete rehabilitation plan. These children's shortage of environmental experience is mainly due to their backwardness as regards motoric development, which cannot be recovered by means of individual physical therapy alone. On the other hand, additional, specifically selected and organised physical education makes possible the necessary mobility and social experiences. By giving the children exercises suitable for their ages it is hoped to achieve a late maturation and stabilization of the personality. In choosing the exercises it is first of all necessary to go back to the so-called fundamental activities like climbing, hanging by one's hands, sliding, pushing oneself up off the ground, swinging or throwing and catching, before going on to wheel-chair sports. Wheel-chair sport promises a varied selection for group exercises (games) and for everyday use. Using the wheel-chair as sports equipment, it is possible for persons with other types of locomotive handicaps to be integrated into the group. For physical education in special schools the pupils whould be arranged into groups according to their ability in order to keep the groups as homogenous and the children's chances as equal as possible. The most important teaching criteria are in this case: the creation of a happy atmosphere, a high degree of clarity, the fulfilment of individual inclinations, the encouragement of independence, the development of community life and the fulfilment of everyday tasks. In swimming, the spina bifida child differs from the normal child in his greater initial fear and in the existence of contractions, a scoliosis, hyperlordosis or -kyphosis due to the resultant instability of the water. Because of this, specifically oriented swim- and work-aids must be used. The didactic procedure is then the same as in the case of normal children. After the child's familiarity with and safety in the water is assured, one can proceed to individual swimming techniques and in a few cases to sport swimming. Bacteriological examination of the water did not yield any results which could cause objection on the grounds of hygiene.
 ...
PMID:[Physical education for spina bifida children in special schools for the physically handicapped (primary school)]. 15 44

An electro-nystagmographic study of postural effects on the nystagmus response has been performed in 40 patients with adolescent idiopathic scoliosis aged from 10 to 16 years. The control group comprised 29 healthy children of the same age. Caloric labyrinthine stimulation was done in the supine and erect position. The results were analysed with the aim of finding out whether an increased scoliotic deformity might influence the labyrinthine response. For comparison of the nystagmus response in the two different positions a quotient of the values (degrees/second) obtained from cold water stimulation in the erect and supine position was calculated. In the control children the labyrinthine response in erect posture was half of the response in supine posture. In erect posture the scoliotic deformity increased. This obvious change in the spine did not increase the caloric response from the convex side labyrinth. The predominance of the convex side labyrinth observed in the supine position was thus not seen in the erect position. The results of this study did not support the assumption that a postural deformity in the spine can influence a calorically induced labyrinthine response.
 ...
PMID:Postural effects on nystagmus response during caloric labyrinthine stimulation in patients with adolescent idiopathic scoliosis. II. An electro-nystagmographic study. 53 84

The aims were to examine the effects of scoliosis (angle), and age on lung volumes, elastic properties of the respiratory system, and the ventilatory response to CO2. The mean age of the 55 patients was 25.4 plus or minus SEM 2.5 yr, and the mean angle was 80 plus or minus SEM 4.2. The mean plus or minus SEM percent predicted lung volumes were vital capacity (VC), 60.5 plus or minus 2.7; total lung capacity (TLC), 70,2 plus or minus 2.6; functional residual capacity (frc), 79.3 plus or minus 3.2; and residual volume (RV), 99.7 plus or minus 5.2. The correlation coefficients between the angle of scoliosis and each of the following were significant: TLC (-0.548), percent predicted TLC (-0.547), VC (-0.485), percent predicted VC (-0.523), FRC (-0.533), percent predicted FRC (-0.338), RV (-0.438), and percent predicted RV (-0.318). The mean compliance of the total respiratory system (Crs) was 0.049 litter/cm H2O plus or minus SEM 0.004, and the mean compliance of the chest wall (Ccw) was 0.080 liter/cm H2O plus or minus SEM 0.012. The Crs and Ccw were inversely proportional to the angle (r-0.620 and -0.721) and directly proportional to the height and the weight. The mean deltaV/deltaPco2 was 1.32 liter/min per mm Hg (SEM 0.171), and the mean deltaVt/deltaPco2 was 28.9 ml/mm Hg (SEM 3.64). The correlation coefficients between deltaV/deltaPco2 and the following were height, 0.499; VC, 0.792; TLC, 0.632; AND Crs, 0.520; and between the deltaTt/deltaPco2 and the following were height, 0.500; VC, 0.878; TLC, 0.802; and Crs, 0.590. We conclude that body size and the deformity were the determinants of the lung volumes and the mechanical properties of the respiratory system, and that these variables were the major factors in both the magnitude and pattern of the ventilatory response to CO2. The correlations between age and the mechanical properties of the respiratory sytem, deltaV/deltaPco2, and deltaVt/deltaPco2, were not significant, but the correlation coefficients between age and several of the derivatives of deltaV/deltaPco2 and deltaVt/deltaPco2 were significant.
 ...
PMID:Idiopathic scoliosis. Mechanical properties of the respiratory system and the ventilatory response to carbon dioxide. 113 65

Since the Scoliosis Research Society released a report on cord injury related to Harrington rod instrumentation for scoliosis, little has been published on the pathophysiology of this disorder. Dolan et al. (4) described diminished cord blood flow associated with spinal distraction in a cat model, but failed to demonstrate its cause. In this article, we describe a series of in vitro experiments performed on dog and sheep cadaver spinal cords. Controlled distractive forces were applied to spinal cords while monitoring both cord interstitial pressure and cord elongation. A close (Ravg = 0.986) correlation was noted between applied tensile forces and cord interstitial pressure. At 1,000-g loads, the average tissue pressure obtained was 29.5 cm H2O, ranging from 17 to 47 cm H2O. However, it was noted that the cord demonstrated nonlinear tensile elastic properties that appeared exponential in the range examined. These properties are consistent with those described for collagen-containing compounds. We conclude that spinal cord distraction is capable of generating cord tissue pressures that could cause a spinal cord compartment syndrome and thereby seriously impair spinal cord blood flow causing spinal cord injury.
 ...
PMID:Spinal cord distraction: an in vitro study of length, tension, and tissue pressure. 180 82

Seven hundred fifty-five children with myelomeningoceles were evaluated radiologically at the Children's Memorial Hospital in Chicago. From our material, we propose a diagnostic radiologic model to accurately evaluate the neurological problems in the myelomeningocele child. This model is based on the clinical symptoms in these children and the radiologic modalities of magnetic resonance imaging (MRI), computed tomography (CT), ultrasound, myelography, and plain radiographs. We found MRI to be the best modality to evaluate the posterior fossa and total spine. Computed tomography and ultrasound are used to evaluate ventricular size. At times MRI may not adequately diagnose subtle cases of tethering of the spinal cord, cord infarction, arachnoid cysts, or diastematomyelia. In these cases, further evaluation may be necessary with real time ultrasound to look at cord pulsations and water soluble myelography with follow through CT to differentiate cord infarction, arachnoid cyst, localized hydromyelia, or diastematomyelia. If MRI is not adequate to completely visualize the cord because of the severe nature of the scoliosis, then water soluble myelography with CT is indicated.
 ...
PMID:The radiological evaluation of the child with a myelomeningocele. 192 May 18

The trend in the aerobic reserve obtained from maximal oxygen utilization and other clinicophysiological indices was investigated for children with scoliosis stage I, II and III on pelotherapy and hydrokinesitherapy in the pool. The aim was to design therapeutic regiments differentiated by the patients' initial functional condition. Baseline reduction of the aerobic reserve was recorded in 35% of the examinees. The response to balneopelotherapy appeared more pronounced when the treatment was adjusted to initial functional condition of the child. Functional classes of scoliosis were defined to justify dosing of balneotherapy and peloids by temperature of water, mud, duration of the procedure and the whole course.
 ...
PMID:[The development of differentiated methods of balneological mud therapy for children with scoliotic disease]. 227 4

Eight paediatric patients undergoing major surgery for correction of scoliosis who were treated postoperatively with hypotonic saline and 5% dextrose have been studied. Plasma sodium, renin and aldosterone, and urine volume, sodium and osmolality were measured. These patients had an impaired ability to excrete a sodium-free water load. In the first 60 h urine volume remained reduced, while in the first 36 h urine sodium remained concurrently high. If the first 36 h postoperation are considered, the sodium-free water given was quantitatively retained and the serum sodium at 36 h was significantly correlated with the amount of free water given (P less than 0.01). To minimize postoperative hyponatraemia and the associated shift of water into the brain causing cerebral oedema, it is recommended that no more than 50 ml/kg sodium-free water be given until urine sodium falls and volume increases.
 ...
PMID:Pathogenesis of postoperative hyponatraemia following correction of scoliosis in children. 307 98

Mechanisms causing the reduction in lung capacity commonly found in adolescents with idiopathic scoliosis (IS) have not been understood. In 29 patients with typical thoracic curvatures of mild to moderate degree (less than 60 degrees), total lung capacity (TLC) was a mean 75 +/- 13% (SD) of predicted. The patients could generate only -70 +/- 26 cm H2O (SD) maximal inspiratory airway pressure at function residual capacity, as compared with -102 +/- 28 cm H2O in 21 normal control subjects (p less than 0.001). Studies of lung mechanics in 15 of the patients showed that maximal transpulmonary pressure at TLC was also reduced. Static pressure volume curves were shifted to the right, and both static and dynamic lung compliance were significantly reduced. Although both upstream conductance per TLC and anatomic dead space per TLC were abnormally high, relationships between maximal expiratory flow and static lung recoil were appropriate for age, indicating a normal growth of airway dimensions. From results of the single-breath nitrogen washout procedure, amounts of trapped nitrogen were also normal, indicating that the low lung compliance is not caused by airway closure. After a 5-min period of positive pressure (25 cm H2O) breathing, dynamic compliance increased by a mean of 34% in subjects with low TLC, and by a significantly smaller (p less than 0.05) mean increase of 14% in subjects with normal TLC. The 15 patients were restudied 1 yr after corrective surgery by the Harrington procedure.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Respiratory mechanics in adolescents with idiopathic scoliosis. 674 6

Using Wister albino rats, bipedal rats were prepared; to which semicarbazide at a concentration of 0.075%, 0.05% and 0.025% were given as drinking water and the rats were divided into three groups A, B and C according to such concentrations. Osteolathyrism was caused in this way and the relations between doses as well as the dosing period and the progress of scoliosis were examined roentgenologically and histologically and the following conclusions were obtained. 1. The frequency of occurrence of scoliosis was 82% in the bipedal rats and 13% in the quadrupedal rats (level of significance alpha = 0.001% or less). 2. Primordial top vertebrae were located concentratively in the lower 1/3 of thoracic vertebra. 3. In the primordial curve, those cases showing a right side curve accounted for 76%. 4. After termination of administration of semicarbazide, spontaneous improvement took place only in those cases showing scoliosis of less than 40 degrees. 5. In the author's experimental scoliosis, the static and dynamic condition of posture nearly coincided with those of men in clinical studies. 6. Histological changes were especially marked in the cartilage layer on the vertebral epiphyseal line, being quite diversified.
 ...
PMID:The experimental study of scoliosis in bipedal rat in lathyrism. 716 97

Of thirty-one patients who underwent posterior fusion for congenital scoliosis from 1972 through 1977 at the Children's Hospital Medical Center, Boston, Massachusetts, and were followed for two years or more, eighteen (average age, fourteen and one-half years and average curve, 62 degrees) were treated by spine fusion using Harrington instrumentation, and thirteen (average age, and one-half years and average curve, 43 degrees) were treated by fusion without instrumentation. Correction of the curve in the instrumented group was obtained at operation, while in the group without instrumentation correction was attempted using a plaster jacket applied during the postoperative period. After an average follow-up of thirty-four months in the group with Harrington instrumentation, the average curve was reduced from 62 to 40 degrees, for an average correction of 22 degrees, while in the non-instrumented group, after an average follow-up of fifty-three months the average curve was reduced from 43 to 38 degrees, for an average correction 5 degrees. A myelogram using water-soluble contrast medium should be performed in all patients who are to have instrumentation and in all patients who have any neural abnormality or are suspected of having diastematomyelia. An intraoperative wake-up test was used in all patients who had instrumentation after 1973 and averted neural complications in one. Proper treatment of congenital scoliosis requires early recognition of curves that have already progressed or will certainly do so. Fusion without instrumentation then is sufficient. If correction is necessary, staged procedures (halo-femoral traction, anterior release, and posterior fusion) may be required for severe curves. For the less severe curves, instrumentation as the primary means of obtaining correction proved to be safe and effective in this small series, but should only be attempted by experienced surgeons in institutions with all of the necessary facilities.
 ...
PMID:Surgical treatment of congenital scoliosis with or without Harrington instrumentation. 721 27


1 2 3 4 5 Next >>