Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0700208 (scoliosis)
 8,574 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Background. The selection of the appropriate type of stabilization in the treatment of thoraco-lumbar scoliosis is still a matter for discussion. Material and methods. We present treatment outcome in a group of 127 patients with thoraco-lumbar scoliosis, operated between 1996-2001. The techniques used were the anterior spinal approach with DIF (direct intercorporal fusion) and three-dimensional CD-Hopf stabilization. Results and Conclusions. Deformities were corrected surgically in 78% of the cases. The average duration of surgery was 150 min, with average intraoperative blood loss of 80 ml. Corrective surgery in scoliosis should stop the progression of deformity. The most important advantage of anterior spinal stabilization is the possibility to shorten the area of spinal fusion and save free moving lumbar segments. The DIF technique gives better fusion and correction of the deformity.
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PMID:Anterior stabilization in thoraco-lumbar scoliosis. 1761 5

Bisphenol A (BPA) is being recognized as an endocrine-disrupting chemical (EDC). Recently, several reports indicated that BPA affects the central nervous system (CNS) during embryonic development. However, the molecular mechanism of BPA in the CNS is not well known. Here, we show that BPA affected Notch signaling by inhibiting the activity of the Notch intracellular domain (NICD) cleavage-related enzyme, gamma-secretase (gamma-secretase), at the neurula stage of the Xenopus laevis. BPA caused various morphologic aberrations including scoliosis, eye dysplasia, and loss of pigments in the X. laevis tadpole. These abnormalities were seen whenever BPA was used at the neurula stage. In addition, the expression levels of several marker mRNAs at the neurula stage were investigated by RT-PCR, and we found that the mRNAs expression of ectodermal marker, Pax6, CNS marker, Sox2, and neural crest marker, FoxD3, were decreased by treatment with BPA. These genes contribute to the neural differentiation at the neurula stage, and also the downstream factors of Notch signaling. Injection of NICD but not a Notch ligand, delta 1, rescued the abnormalities caused by BPA. We subsequently assayed the inhibition of the activities of NICD cleavage-related enzymes, tumor necrosis factor alpha converting enzyme, and gamma-secretase, by BPA and found that BPA inhibited the gamma-secretase activity. Furthermore, we expressed presenilin, a main component of gamma-secretase, in Escherichia coli and found the direct binding of BPA with presenilin. These results suggest that BPA affected the neural differentiation by inhibiting gamma-secretase activity, leading to neurodevelopmental abnormalities.
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PMID:Bisphenol A disrupts Notch signaling by inhibiting gamma-secretase activity and causes eye dysplasia of Xenopus laevis. 1921 31