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Query: UMLS:C0700208 (scoliosis)
 8,574 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Congenital anomalies of the cervical spine are uncommon. The majority of afflicted individuals are asymptomatic or have only mild restriction of neck motion. If symptoms develop, they are usually due to cervical instability or degenerative osteoarthrosis. Recent information indicates that patients with upper cervical anomalies such as atlantooccipital fusion, anomalies of the odontoid, or the transverse atlantal ligament have a great propensity to develop early instability and neurologic problems secondary to minor traumatic events. If symptoms occurs in the lower cervical spine, it is usually in adult life and due to degenerative arthritis in the hypermobile articulations adjacent to the area of synostosis. The relatively good prognosis of cervical lesions is overshadowed by the "hidden" or unrecognized associated anomalies. There is a high incidence of significant scoliosis, Sprengel's deformity, renal anomalies, deafness, and neurologic malformations. Early recognition and treatment of these problems may be of substantial benefit, sparing the patient further deformity or serious illness.
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PMID:Congenital anomalies of the cervical spine. 199 31

Congenital anomalies were seen at necropsy of two neonatal tamarins. The defects included achondroplastic-like dwarfism, polydactyly and syndactyly in a Saguinus oedipus, and scoliosis and uterus didelphys in a S. fuscicollis. Both infants were the offspring of incestuous matings between twin siblings.
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PMID:Congenital anomalies in two neonatal tamarins (Saguinus oedipus and Saguinus fuscicollis). 302 46

Congenital anomalies of the spine usually originate in (toxic) disturbances during pregnancy. There are occasional hereditary types. These are characterized by the presence of multiple anomalies. Congenital scolioses are often associated with other anomalies like spinal dysraphy (20-30%) and fusion of the ribs. Furthermore heart defects, Sprengel's deformity, cleft palates, hemimelias, clubfeet or congenital vertical talus are frequently associated with congenital scoliosis. We classify in failures of formation, segmentation and combined types. The type of malformation determines the prognosis. One hemivertebra is associated with a risk of progression of 0-2 degrees/year, 2 ipsilateral hemivertebra with 2-3 degrees/year, a unilateral unsegmented bar with 5 degrees/year and a combination of a unilateral unsegmented bar with a contralateral hemivertebra with approximately 10 degrees/year. Conservative treatment is usually ineffective. The indication for operative treatment should be made before the deformity becomes unacceptable, as a correction is difficult and dangerous. The following operations can be carried out: Anterior and/or posterior fusion with or without instrumentation, epiphyseodesis, (hemi)vertebrectomies (with anterior and/or posterior approach), distraction with a halo, osteotomies, separation of the fused ribs and gradual distraction (Campbell's expansion thoracoplasty). The operations carry significant risks and the indication to the various treatment modalities is difficult. Operations should be made under monitoring of sensory and motor evoked potentials. From 498 patients with congenital anomalies of the spine in our observation we have operated on 143. Hemivertebrectomies were the most frequent interventions (56).
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PMID:[Congenital anomalies of the spine]. 1196 67

Congenital anomalies of the vertebrae producing a scoliosis, kyphoscoliosis or kyphosis are potentially serious conditions, which can, on occasion, result in an extremely severe rigid spinal deformity with possible spinal cord compression. The key to successful management depends on: (1) Early diagnosis while the curve is still small. (2) Anticipation of the likely prognosis based on the type and site of the vertebral anomaly, the degree of growth imbalance it produces and the amount of spinal growth remaining. (3) Preventing progression of the deformity and this may necessitate surgical treatment in the first few years of life. It is much better to carry out a relatively simple operation to balance the growth of the spine at an early stage than to wait and perform potentially hazardous anterior and posterior spinal surgery as a salvage procedure at a later stage.
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PMID:James IV Lecture: congenital deformities of the spine. 1201 90

The thrombocytopenia-absent radius (TAR) syndrome is a congenital malformation syndrome characterised by bilateral absence of the radii and a thrombocytopenia. The lower limbs, gastrointestinal, cardiovascular, and other systems may also be involved. Shaw and Oliver in 1959 were the first to describe this condition, but it was Hall et al in 1969 who reported the first major series of patients. Since then most reports have been based on single or small numbers of cases. We report the results of a clinical study looking at the phenotype of 34 patients with TAR syndrome. All cases had a documented thrombocytopenia and bilateral radial aplasia, 47% had lower limb anomalies, 47% cow's milk intolerance, 23% renal anomalies, and 15% cardiac anomalies. Congenital anomalies not previously described in association with TAR syndrome included facial capillary haemangiomata, intracranial vascular malformation, sensorineural hearing loss, and scoliosis. Karyotype analysis, chromosome breakage studies including premature centromeric separation and fluorescence in situ hybridisation studies looking for a deletion of chromosome 22q11 were undertaken. Two abnormal karyotypes were identified.
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PMID:Thrombocytopenia-absent radius syndrome: a clinical genetic study. 1247 Nov 99

Congenital anomalies in horses are very rare, and contracted foal syndrome is one of the most commonly reported. This malformation is characterized by contraction of the joints of the forelimbs and/or hindlimbs. In addition, the syndrome can be characterized by vertebral column malformations, such as scoliosis or torticollis, and cranial deformity. The present report describes the radiological and necroscopical findings of multiple rare malformations in two foals. Both foals showed skeletal abnormalities and fenestration of the abdominal cavity. Other pathological findings include a interventricular septal defect in one and a unilateral hydronephrosis and partial hydroureter in the other foal. Although in this report a specific aetiology could not be provided, insecticides treatment provided during the second month of pregnancy might play a role in the pathogenesis of these malformations.
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PMID:Contracted foal syndrome associated with multiple malformations in two foals. 2340 78