Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0700208 (scoliosis)
 8,574 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This third autopsy study of 23 centenarians (7 men and 16 women) included the pathologic examination of bone, the detection of malignant neoplasms, and the determination of the main and contributory causes of death. (Previous studies concerned the lungs and the cardiovascular, urogenital and digestive systems). The vertebral bone specimens showed definite osteoporosis in 14 of the 23 subjects. In some cases it was associated with kyphosis or scoliosis of the spine or a history of femoral fracture. Eight malignant neoplasms were observed in six patients. Prostatic cancers were found in three of the seven men. All the cancers were well differentiated structurally. Four latent cancers were detected at autopsy. Most of these centenarians died of bronchopneumonia or myocardial fibrosis. Death from a malignant neoplasm was uncommon, and usually the cancer was only a contributory cause. The importance of atherosclerosis prevention is stressed by the fact that atherosclerosis was the basic cause of the cardiovascular lesions that constituted a main cause of death.
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PMID:Pathology of centenarians. III. Osseous system, malignant lesions, and causes of death. 71 21

Longstanding scoliosis of the lumbar spine with convexity to the left leads to severe atherosclerosis in the adjacent segment of the abdominal aorta. By contrast, the lateral wall of the ascending aorta, which is free to pulsate, usually is not affected even in very old persons. This relative immunity, however, is not maintained in cases of syphilitic mesaortitis; damage to the elastic tissues of the media leads to atherosclerosis. Man is the only mammal known to be highly susceptible to severe atherosclerosis. The concept is advanced that the erect posture of man, which leads to the physiologic anterior curvature of the lumbar spine, predisposes to atheroma formation in the abdominal aorta, particularly in women. Evidence for the osteoporosis-atherosclerosis concept is presented. Sustained muscular activity starting early in life can delay osteoporosis and atherosclerosis. A possible mechanism for the onset and gradual progression of physiologic osteoporosis is suggested. The concept of atherogenesis advanced here is based on observations which suggest a correlation of aging processes in the mesenchymal tissues. These aging processes, in conjunction with mechanical factors partly caused by the erect posture, may account for the unique susceptibility of man to severe atherosclerosis.
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PMID:Observations on the natural history of atherogenesis. 124 85

Isolated spontaneous renal artery dissection (RAD) without known trauma is rare, and its etiology has not been determined. However, notable risk factors including hypertension, strenuous exercise, connective tissue disorders, atherosclerosis, extracorporeal shock wave lithotripsy, and cocaine abuse have been reported. To the best of our knowledge, isolated RAD caused by lumbar vertebra osteophytes in patients with degenerative lumbar scoliosis has not been reported in the literature. In this article, we present a case of RAD caused by lumbar vertebra osteophyte in a patient with degenerative scoliosis and discuss the management of the disease.
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PMID:Renal Artery Dissection in a Patient With Degenerative Scoliosis: A Rare Complication Caused by Lumbar Vertebra Osteophyte. 2949 58