Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Sep
1826
Mol
1719
p53
1510
colon carcinoma
1001
caspase-3
842
catenin
712
Bcl-2
607
p21
551
cage
462
gut
458
beta-catenin
439
DLD
407
cytokine
402
E-cadherin
385
AKT
383
COX-2
380
cyclin D1
376
carcinoembryonic antigen
353
APC
344
cyclooxygenase-2
339
vascular endothelial growth factor
317
NMR
315
KRAS
313
ERK
308
epidermal growth factor receptor
295
PARP
283
PI3K
275
insulin
273
adenomatous polyposis coli
273
She
259
MAPK
258
histone
256
mucin
253
CEA
250
p38
250
mTOR
246
caspase-9
243
tumor necrosis factor
235
cytochrome c
228
TNF
219
BRAF
219
IL-6
218
caspase-8
214
cyclooxygenase
213
ERK1
211
c-Myc
210
CD44
208
proliferating cell nuclear antigen
198
EGFR
195
tyrosine kinase
186
collagen
183
TNM
181
endoplasmic reticulum
180
CD8
178
annexin V
177
ras
174
glycoprotein
172
ATP
171
survivin
171
VEGF
169
MLH1
169
ROS
166
proteasome
161
STAT3
157
matrix metalloproteinase
156
p65
155
c-myc
153
histone deacetylase
152
CRC
151
MEK
150
CD133
150
inducible nitric oxide synthase
148
thymidylate synthase
147
JNK
146
lymphoid
145
p27
142
Fas
138
epidermal growth factor
136
IFN
134
MMP-9
134
more...
Disease
colon cancer
28837
cancer
15677
tumor
9605
colorectal cancer
5506
carcinogenesis
2325
breast cancer
1773
carcinoma
1716
adenocarcinoma
1671
metastases
1619
tumor growth
1517
tumorigenesis
1426
rectal cancer
1160
Colon cancer
1100
lung cancer
979
tumor progression
908
gastric cancer
797
melanoma
785
prostate cancer
613
adenoma
610
colitis
602
liver metastases
556
leukemia
480
inflammatory bowel disease
467
ulcerative colitis
460
pancreatic cancer
447
hepatocellular carcinoma
447
MCF
420
familial adenomatous polyposis
409
ovarian cancer
407
polyposis
379
obesity
353
APC
345
Colon
344
Colon
344
Colon
344
primary tumor
325
Dukes
319
diabetes
294
liver cancer
287
dysplasia
280
liver cancer
241
lymphoma
225
Crohn's disease
215
metastatic colon cancer
209
Lynch syndrome
203
cervical cancer
189
non-small cell lung cancer
180
bladder cancer
179
gastrointestinal cancer
164
squamous cell carcinoma
160
hypertension
156
anemia
152
renal cell carcinoma
148
renal cancer
147
bowel obstruction
146
esophageal cancer
140
glioblastoma
131
lung metastases
129
solid tumor
128
endometrial cancer
126
esophageal cancer
125
adenocarcinoma of the colon
125
multiple myeloma
121
tumor angiogenesis
120
glioma
116
cardiovascular disease
116
lung carcinoma
115
sarcoma
112
Colorectal Cancer
109
retinoblastoma
108
aggressiveness
107
stage III colon cancer
106
carcinomatosis
105
GSH
97
SCID
94
Rectum
93
Rectum
93
Rectum
93
Rectum
93
type 2 diabetes
92
more...
Symptom
diarrhea
262
abdominal pain
223
pain
189
constipation
98
nausea
95
vomiting
85
fatigue
78
starvation
66
anesthesia
62
overweight
61
colic
55
anorexia
55
nausea and vomiting
52
discomfort
29
discomfort
29
dyspnea
28
cough
25
headache
24
cachexia
22
weakness
20
back pain
19
analgesia
18
chills
16
Ill
16
menopausal symptoms
15
chest pain
14
erythema
13
abdominal discomfort
13
collapse
13
abdominal fullness
12
ataxia
12
seizures
12
Wind
12
bloating
12
dizziness
11
angina
11
splenomegaly
11
shortness of breath
9
epigastric pain
9
vertigo
8
exhaustion
8
numbness
8
flushing
8
acidity
8
asthenia
7
HSA
7
hot flashes
7
acute abdomen
7
fever of unknown origin
7
paresthesia
6
pelvic pain
6
dysarthria
6
hepatomegaly
6
hoarseness
6
Sister Mary Joseph's nodule
6
low back pain
6
flank pain
6
arthralgia
5
sleepiness
5
intestinal bleeding
5
cancer pain
5
tenesmus
5
chronic constipation
5
acute abdominal pain
4
decreased appetite
4
lethargy
4
hemoptysis
4
agitation
4
respiratory distress
4
hypoproteinemia
3
tinnitus
3
leg edema
3
pneumaturia
3
acute pain
3
myalgia
3
left lower quadrant pain
3
thinning
3
left upper quadrant pain
3
persistent cough
3
physical appearance
3
more...
Drug
CPT-11
199
ROS
166
lysine
117
Oxaliplatin
96
Leucovorin
84
vitamin E
75
IL-2
70
ascorbate
66
IFN-gamma
65
Irinotecan
60
Bevacizumab
46
GEO
45
Bifidobacterium
44
Cetuximab
38
Adriamycin
38
Dermatol
37
Monit
36
caffeine
31
CSF
29
Taxol
25
lactose
25
Glutathione
25
Cardiovasc
25
ADM
23
MAP
22
ROC
22
Mutagen
21
Indomethacin
20
NADH
19
ABC
19
Gel
18
CAM
18
THF
18
MRC
17
uPA
17
Xeloda
16
ADR
16
Imatinib
16
Gefitinib
15
Vitamin E
15
CTC
15
G-CSF
15
G418
15
ALA
15
niacin
14
Heme
14
EPA
14
Vitamin A
14
CTC
13
CCL
13
Sorafenib
13
Asn
12
Leaf
12
Lovastatin
12
Herceptin
12
Panitumumab
11
Bortezomib
11
Portal
11
Ethanol
10
Nitric Oxide
10
Fluorescein
9
DNase I
9
EE2
9
Pemetrexed
9
Activin
9
Etoposide
9
Norplant
9
Simvastatin
9
Troglitazone
8
Lipiodol
8
Ginger
8
Ginseng
8
CPR
8
ICI
7
Meth
7
citric acid
7
TTC
7
Glycyrrhiza
7
Paraffin
7
Gleevec
7
more...
Enzyme
mitogen-activated protein kinase
813
ERK
753
caspase-3
651
protein kinase
382
luciferase
372
APC
348
PARP
313
focal adhesion kinase
268
MEK
211
caspase-9
190
protein kinase C
190
proteasome
162
thymidylate synthase
156
caspase-8
152
catalase
124
alkaline phosphatase
117
topoisomerase
112
topoisomerase
108
P-glycoprotein
108
superoxide dismutase
104
cdc2
102
GSK
100
ornithine decarboxylase
94
phosphatidylinositol 3-kinase
91
AMP-activated protein kinase
91
reverse transcriptase
90
glutathione S-transferase
88
urokinase-type plasminogen activator
85
peroxidase
74
lactate dehydrogenase
70
ATPase
69
ACS
65
thymidine kinase
63
MMP
63
glutathione peroxidase
60
NQO1
58
phosphoinositide 3-kinase
57
DNA methyltransferase
52
trypsin
51
beta-glucuronidase
49
AMPK
49
collagenase
47
AMPK
42
RNA polymerase
40
dihydropyrimidine dehydrogenase
37
neuraminidase
36
thymidine phosphorylase
35
granzyme B
34
MDR
34
calcineurin
32
phospholipase A2
32
lipoxygenase
31
RNase
31
aldehyde dehydrogenase
30
sialyltransferase
29
RNase
29
sialyltransferase
29
aldehyde dehydrogenase
29
sialyltransferase
29
DNA polymerase
29
aldehyde dehydrogenase
27
aldehyde dehydrogenase
27
aldehyde dehydrogenase
27
caspase-7
27
thrombin
27
beta-galactosidase
27
alanine aminotransferase
27
caspase-7
27
dihydropyrimidine dehydrogenase
27
PDK1
25
NO synthase
25
sucrase
25
IKK
25
glutathione reductase
24
endonuclease
24
phosphodiesterase
24
NADPH oxidase
24
dihydrofolate reductase
24
ribonucleotide reductase
24
phospholipase C
23
more...
Compound
DNA
2941
Dec
2065
Clin
1361
oxygen
728
MTT
695
sodium
614
5-FU
580
water
571
calcium
525
sulfate
404
glucose
392
1,2-dimethylhydrazine
273
tyrosine
255
MDA
244
phosphate
221
TNF
219
vitamin D
214
acetate
206
bromide
198
CPT-11
198
nitric oxide
198
iron
184
TNM
181
serine
178
ethanol
175
galactose
171
ATP
171
methionine
159
cysteine
150
lysine
148
barium
148
hydrogen
145
MEK
145
Curcumin
140
iodine
138
threonine
133
PEG
126
selenium
125
ASA
124
arginine
115
GSH
113
GSH
113
His
111
butyric acid
110
zinc
110
PGE
99
Pac
99
nitrogen
98
methanol
97
PEG
96
folinic acid
96
DSS
93
leucine
90
salt
87
PGE2
86
retinoic acid
83
Adriamycin
82
SN-38
82
Leucovorin
80
copper
78
DPPH
72
ACS
66
ethyl acetate
66
N-acetylcysteine
65
pyrimidine
65
pyrimidine
65
ACS
65
SDS
65
pyridine
64
alanine
63
acridine
63
cAMP
62
urea
61
TOF
61
COX
61
ADR
60
dUTP
60
Resveratrol
57
silver
57
NH2
56
more...