Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 1826
Mol 1719
p53 1510
colon carcinoma 1001
caspase-3 842
catenin 712
Bcl-2 607
p21 551
cage 462
gut 458
beta-catenin 439
DLD 407
cytokine 402
E-cadherin 385
AKT 383
COX-2 380
cyclin D1 376
carcinoembryonic antigen 353
APC 344
cyclooxygenase-2 339
vascular endothelial growth factor 317
NMR 315
KRAS 313
ERK 308
epidermal growth factor receptor 295
PARP 283
PI3K 275
adenomatous polyposis coli 273
insulin 273
She 259
MAPK 258
histone 256
mucin 253
CEA 250
p38 250
mTOR 246
caspase-9 243
tumor necrosis factor 235
cytochrome c 228
TNF 219
BRAF 219
IL-6 218
caspase-8 214
cyclooxygenase 213
ERK1 211
c-Myc 210
CD44 208
proliferating cell nuclear antigen 198
EGFR 195
tyrosine kinase 186
collagen 183
TNM 181
endoplasmic reticulum 180
CD8 178
annexin V 177
ras 174
glycoprotein 172
ATP 171
survivin 171
MLH1 169
VEGF 169
ROS 166
proteasome 161
STAT3 157
matrix metalloproteinase 156
p65 155
c-myc 153
histone deacetylase 152
CRC 151
MEK 150
CD133 150
inducible nitric oxide synthase 148
thymidylate synthase 147
JNK 146
lymphoid 145
p27 142
Fas 138
epidermal growth factor 136
MMP-9 134
IFN 134
extracellular signal-regulated kinase 131
interferon 131
MSH2 128
CD4 125
fibronectin 122
nodal 119
alkaline phosphatase 117
cyclin 116
c-Jun 116
COX-1 115
MMP-2 114
PC-3 108
K-ras 108
Ki-67 108
vimentin 108
ubiquitin 108
lipopolysaccharide 108
TRAIL 107
P-glycoprotein 107
lectin 105
IL-10 104
type II collagen 104
peroxisome proliferator-activated receptor gamma 104
UTR 100
PTEN 100
phosphatase 99
IL-8 97
GSH 97
catalase 96
cyclin E 95
topoisomerase I 95
hMLH1 94
ornithine decarboxylase 94
TCF 94
poly(ADP-ribose) polymerase 93
chemokine 92
vitamin D receptor 92
phosphatidylinositol 3-kinase 91
mutant p53 90
tumour suppressor 90
DSS 90
estrogen receptor 89
TNF-alpha 88
CCD 86
CDK4 86
MRI 86
GSK 86
gastrin 85
insulin-like growth factor 84
AP-1 83
Sp1 81
osteosarcoma 79
WAF1 79
fused 78
BAX 78
p16 78
leptin 78
FDG 77
EGF 76
DR5 75
cyclin B1 75
threonine 74
urokinase-type plasminogen activator 74
superoxide dismutase 73
cyclin-dependent kinase 73
PKC 73
hemoglobin 72
Rho 71
interleukin-6 71
focal adhesion kinase 71
N-cadherin 71
MSH6 70
hMSH2 69
IL-2 69
PIK3CA 68
kit 68
polypeptide 67
IFN-gamma 66
histone H3 66
TGF-beta 66
more...
Disease
colon cancer 28837
cancer 15677
tumor 9605
colorectal cancer 5506
carcinogenesis 2325
breast cancer 1773
carcinoma 1716
adenocarcinoma 1671
metastases 1619
tumor growth 1517
tumorigenesis 1426
rectal cancer 1160
Colon cancer 1100
lung cancer 979
tumor progression 908
gastric cancer 797
melanoma 785
prostate cancer 613
adenoma 610
colitis 602
liver metastases 556
leukemia 480
inflammatory bowel disease 467
ulcerative colitis 460
pancreatic cancer 447
hepatocellular carcinoma 447
MCF 420
familial adenomatous polyposis 409
ovarian cancer 407
polyposis 379
obesity 353
APC 345
Colon 344
Colon 344
Colon 344
primary tumor 325
Dukes 319
diabetes 294
liver cancer 287
dysplasia 280
liver cancer 241
lymphoma 225
Crohn's disease 215
metastatic colon cancer 209
Lynch syndrome 203
cervical cancer 189
non-small cell lung cancer 180
bladder cancer 179
gastrointestinal cancer 164
squamous cell carcinoma 160
hypertension 156
anemia 152
renal cell carcinoma 148
renal cancer 147
bowel obstruction 146
esophageal cancer 140
glioblastoma 131
lung metastases 129
solid tumor 128
endometrial cancer 126
adenocarcinoma of the colon 125
esophageal cancer 125
multiple myeloma 121
tumor angiogenesis 120
cardiovascular disease 116
glioma 116
lung carcinoma 115
sarcoma 112
Colorectal Cancer 109
retinoblastoma 108
aggressiveness 107
stage III colon cancer 106
carcinomatosis 105
GSH 97
SCID 94
Rectum 93
Rectum 93
Rectum 93
Rectum 93
type 2 diabetes 92
DSS 90
DSS 90
AIN 86
CCD 86
CCD 86
osteosarcoma 85
tumor initiation 83
ileus 82
osteoporosis 82
thrombocytopenia 82
neuroblastoma 79
neutropenia 79
skin cancer 78
stage II colon cancer 78
B-cell lymphoma 77
neoplastic transformation 74
peritonitis 72
Hodgkin's disease 70
irritable bowel syndrome 68
sepsis 68
diverticular disease 67
acute myeloid leukemia 67
MTS 66
depression 65
cancer recurrence 65
cirrhosis 65
Alzheimer's disease 64
thyroid cancer 63
DDP 62
diverticulitis 61
sepsis 60
stroke 59
intestinal cancer 59
uterus 59
SDS 59
coronary heart disease 59
cold 58
HNPCC 58
gallstones 58
ATM 56
heart disease 56
non-Hodgkin's lymphoma 56
adenomatous polyp 54
HCA 52
atherosclerosis 51
SEM 50
small cell lung cancer 49
epithelial ovarian cancer 49
head and neck cancer 49
stomatitis 48
EMT 48
Blocking 47
leukopenia 45
invasive cancer 44
rheumatoid arthritis 44
infectious diseases 43
NOD 43
hyperinsulinemia 43
ureter 43
HIV 43
chronic myeloid leukemia 43
fibrosarcoma 42
herpes simplex 42
suicide 42
arthritis 41
recurrent colon cancer 41
asthma 40
coronary artery disease 40
myelosuppression 40
brain tumor 40
metabolic syndrome 39
Barrett's esophagus 39
residual disease 38
liver disease 38
malnutrition 38
mesothelioma 37
Gardner's syndrome 37
Adhesion 36
myocardial infarction 36
hematologic malignancies 35
more...
Symptom
diarrhea 262
abdominal pain 223
pain 189
constipation 98
nausea 95
vomiting 85
fatigue 78
starvation 66
anesthesia 62
overweight 61
colic 55
anorexia 55
nausea and vomiting 52
discomfort 29
discomfort 29
dyspnea 28
cough 25
headache 24
cachexia 22
weakness 20
back pain 19
analgesia 18
chills 16
Ill 16
menopausal symptoms 15
chest pain 14
erythema 13
abdominal discomfort 13
collapse 13
bloating 12
abdominal fullness 12
ataxia 12
seizures 12
Wind 12
dizziness 11
angina 11
splenomegaly 11
epigastric pain 9
shortness of breath 9
flushing 8
vertigo 8
exhaustion 8
acidity 8
numbness 8
fever of unknown origin 7
hot flashes 7
acute abdomen 7
asthenia 7
HSA 7
flank pain 6
paresthesia 6
pelvic pain 6
hepatomegaly 6
hoarseness 6
Sister Mary Joseph's nodule 6
dysarthria 6
low back pain 6
arthralgia 5
tenesmus 5
sleepiness 5
intestinal bleeding 5
chronic constipation 5
cancer pain 5
lethargy 4
hemoptysis 4
acute abdominal pain 4
agitation 4
respiratory distress 4
decreased appetite 4
tinnitus 3
myalgia 3
hypoproteinemia 3
heartburn 3
thinning 3
left lower quadrant pain 3
left upper quadrant pain 3
physical appearance 3
persistent cough 3
pneumaturia 3
leg edema 3
acute pain 3
exertional dyspnea 3
oliguria 3
stridor 3
skin irritation 3
anal pain 3
tremor 2
consciousness disturbance 2
Neuropathic pain 2
hyperemesis gravidarum 2
hot flushes 2
skin damage 2
frequent urination 2
distraction 2
cerebellar ataxia 2
Scratch 2
muscle stiffness 2
hepatosplenomegaly 2
Gastrointestinal symptoms 2
No adverse effect 2
clubbing 2
cyanosis 2
spasm 2
functional recovery 2
DNA marker 2
ataxic gait 2
dysuria 2
Postoperative pain 2
right upper quadrant pain 2
night sweats 2
dysesthesia 2
syncope 2
urinary frequency 2
Anoxia 2
breakthrough pain 1
clumsiness 1
halitosis 1
nerve pain 1
Opposition 1
precordial pain 1
productive cough 1
hemiplegia 1
insomnia 1
PUO 1
hip pain 1
hyperoxia 1
hypercapnia 1
microbial colonization 1
Flare 1
spasticity 1
lightheadedness 1
rectal pain 1
wheezing 1
hypothermia 1
iliac fossa pain 1
thigh pain 1
ENT 1
Chills and fever 1
apathy 1
hypotonia 1
dyschezia 1
feeling worried 1
abdominal cramps 1
groin pain 1
nipple discharge 1
limb pain 1
rigors 1
chronic cough 1
infant diarrhea 1
nipple discharge 1
penile lesion 1
Functional abdominal pain 1
alexithymia 1
Stiffness 1
corpulence 1
body pain 1
hopelessness 1
ophthalmoplegia 1
fasciculation 1
Skin symptoms 1
more...
Drug
CPT-11 199
ROS 166
lysine 117
Oxaliplatin 96
Leucovorin 84
vitamin E 75
IL-2 70
ascorbate 66
IFN-gamma 65
Irinotecan 60
Bevacizumab 46
GEO 45
Bifidobacterium 44
Cetuximab 38
Adriamycin 38
Dermatol 37
Monit 36
caffeine 31
CSF 29
lactose 25
Cardiovasc 25
Glutathione 25
Taxol 25
ADM 23
MAP 22
ROC 22
Mutagen 21
Indomethacin 20
NADH 19
ABC 19
CAM 18
THF 18
Gel 18
MRC 17
uPA 17
Xeloda 16
ADR 16
Imatinib 16
Vitamin E 15
CTC 15
G418 15
ALA 15
Gefitinib 15
G-CSF 15
Heme 14
Vitamin A 14
niacin 14
EPA 14
Sorafenib 13
CTC 13
CCL 13
Asn 12
Leaf 12
Lovastatin 12
Herceptin 12
Panitumumab 11
Bortezomib 11
Portal 11
Ethanol 10
Nitric Oxide 10
DNase I 9
Activin 9
Pemetrexed 9
Norplant 9
Simvastatin 9
EE2 9
Etoposide 9
Fluorescein 9
CPR 8
Troglitazone 8
Lipiodol 8
Ginger 8
Ginseng 8
ACT 7
Retinoic acid 7
Paraffin 7
IL-11 7
citric acid 7
NH3 7
Glycyrrhiza 7
TTC 7
Emodin 7
Meth 7
IL-1ra 7
Emodin 7
Gleevec 7
ICI 7
IFN-beta 6
CoCl2 6
ampicillin 6
CoCl2 6
NBT 6
TAC 6
PTH 6
MOF 6
CaCl2 6
Gelatin 6
TAT 6
NVP 6
Docetaxel 6
CDX 6
CDX 6
Photofrin 6
Raloxifene 5
Tocopherol 5
Alliance 5
AZT 5
CaCl2 5
CaCl2 5
Histamine 5
nitroglycerin 5
Doxifluridine 5
p75 5
VCR 5
DPA 5
ENT 5
ETS 5
Epigallocatechin 5
CTX 5
Rosiglitazone 5
Vioxx 5
Glucagon 5
Fraction 4
Rutin 4
Pravastatin 4
Infliximab 4
Aloe 4
Infliximab 4
ZnO 4
CTX 4
Rituximab 4
NAG 4
Fluorescein 4
Cimetidine 4
Silica 4
PTC 4
Cremophor EL 4
DM1 4
Dihydro 4
CTX 4
BLM 4
Cimetidine 4
VCR 4
AMC 4
Erlotinib 4
Everolimus 4
Dasatinib 4
AZT 4
-deoxyadenosine 3
Urokinase 3
LCM 3
OTC 3
Growth hormone 3
PFT 3
Corn oil 3
Olive oil 3
Methylene blue 3
OTC 3
Celebrex 3
CPM 3
more...
Enzyme
mitogen-activated protein kinase 813
ERK 753
caspase-3 651
protein kinase 382
luciferase 372
APC 348
PARP 313
focal adhesion kinase 268
MEK 211
caspase-9 190
protein kinase C 190
proteasome 162
thymidylate synthase 156
caspase-8 152
catalase 124
alkaline phosphatase 117
topoisomerase 112
topoisomerase 108
P-glycoprotein 108
superoxide dismutase 104
cdc2 102
GSK 100
ornithine decarboxylase 94
AMP-activated protein kinase 91
phosphatidylinositol 3-kinase 91
reverse transcriptase 90
glutathione S-transferase 88
urokinase-type plasminogen activator 85
peroxidase 74
lactate dehydrogenase 70
ATPase 69
ACS 65
thymidine kinase 63
MMP 63
glutathione peroxidase 60
NQO1 58
phosphoinositide 3-kinase 57
DNA methyltransferase 52
trypsin 51
beta-glucuronidase 49
AMPK 49
collagenase 47
AMPK 42
RNA polymerase 40
dihydropyrimidine dehydrogenase 37
neuraminidase 36
thymidine phosphorylase 35
MDR 34
granzyme B 34
phospholipase A2 32
calcineurin 32
RNase 31
lipoxygenase 31
aldehyde dehydrogenase 30
RNase 29
DNA polymerase 29
aldehyde dehydrogenase 29
sialyltransferase 29
sialyltransferase 29
sialyltransferase 29
aldehyde dehydrogenase 27
dihydropyrimidine dehydrogenase 27
aldehyde dehydrogenase 27
thrombin 27
aldehyde dehydrogenase 27
caspase-7 27
caspase-7 27
beta-galactosidase 27
alanine aminotransferase 27
IKK 25
NO synthase 25
sucrase 25
PDK1 25
endonuclease 24
NADPH oxidase 24
dihydrofolate reductase 24
glutathione reductase 24
phosphodiesterase 24
ribonucleotide reductase 24
aspartate aminotransferase 23
phospholipase C 23
NADPH oxidase 22
15-hydroxyprostaglandin dehydrogenase 22
ribonucleotide reductase 22
MAP 21
pyruvate kinase 21
thioredoxin reductase 21
cathepsin B 20
caspase-1 20
cytosine deaminase 20
demethylase 20
UDP-glucuronosyltransferase 20
sucrase-isomaltase 19
transcriptase 19
methylenetetrahydrofolate reductase 19
methylenetetrahydrofolate reductase 19
aldose reductase 18
gamma-glutamyl transpeptidase 18
alcohol dehydrogenase 17
ACE 17
matrix metalloproteinase 9 17
15-lipoxygenase 17
PKG 16
plasmin 16
ALDH 16
cathepsin D 16
glucose-6-phosphate dehydrogenase 16
histone acetyltransferase 16
beta-glucosidase 15
beta-glucosidase 15
N-acetyltransferase 15
sialidase 15
glyceraldehyde-3-phosphate dehydrogenase 14
hexokinase 14
acetylcholinesterase 14
protein phosphatase 2A 14
ADH 14
caspase-2 14
tissue plasminogen activator 14
CPT 14
CD10 14
adenylate cyclase 14
caspase-2 14
arginase 14
CPT 13
matrix metalloproteinase 2 13
CPT 13
prostate-specific antigen 13
hexosaminidase 12
NOS 12
TdT 12
TSA 12
histone demethylase 12
invertase 12
hyaluronidase 12
pepsin 12
MIP 11
carbonic anhydrase 11
ATP synthase 11
BAT 11
CPR 11
heme oxygenase 11
AST 11
MMP-3 11
guanylate cyclase 11
CYP3A4 11
succinate dehydrogenase 11
lysozyme 10
farnesyltransferase 10
hyaluronidase 10
prostaglandin synthetase 10
farnesyltransferase 10
carboxylesterase 10
DNA ligase 10
DNA ligase 10
creatine kinase 10
folylpolyglutamate synthetase 9
caspase-6 9
N-acetylglucosaminyltransferase 9
O-GlcNAc transferase 9
more...
Compound
DNA 2941
Dec 2065
Clin 1361
oxygen 728
MTT 695
sodium 614
5-FU 580
water 571
calcium 525
sulfate 404
glucose 392
1,2-dimethylhydrazine 273
tyrosine 255
MDA 244
phosphate 221
TNF 219
vitamin D 214
acetate 206
nitric oxide 198
CPT-11 198
bromide 198
iron 184
TNM 181
serine 178
ethanol 175
galactose 171
ATP 171
methionine 159
cysteine 150
lysine 148
barium 148
hydrogen 145
MEK 145
Curcumin 140
iodine 138
threonine 133
PEG 126
selenium 125
ASA 124
arginine 115
GSH 113
GSH 113
His 111
butyric acid 110
zinc 110
Pac 99
PGE 99
nitrogen 98
methanol 97
folinic acid 96
PEG 96
DSS 93
leucine 90
salt 87
PGE2 86
retinoic acid 83
SN-38 82
Adriamycin 82
Leucovorin 80
copper 78
DPPH 72
ethyl acetate 66
ACS 66
pyrimidine 65
N-acetylcysteine 65
SDS 65
pyrimidine 65
ACS 65
pyridine 64
acridine 63
alanine 63
cAMP 62
TOF 61
urea 61
COX 61
dUTP 60
ADR 60
Resveratrol 57
silver 57
NH2 56
GalNAc 55
PGA 55
quinoline 54
quinoline 53
Capecitabine 52
HCA 52
Asp 51
MMC 50
ADP 50
NAD 49
GlcNAc 49
ADP-ribose 49
H2O2 49
Phe 48
DDP 47
glutamine 47
PMA 47
Celecoxib 46
potassium 46
Vitamin D 46
THP 45
Insulin 44
THP 44
hexane 43
CO2 43
MTS 42
AMP 42
NAD 42
ammonia 41
Sulindac 41
Vimentin 41
ADP 40
ADP 40
hydrazine 39
acetic acid 39
Gly 39
boron 39
hyaluronic acid 39
gallic acid 39
GTP 38
cGMP 38
phenol 38
aldehyde 38
creatinine 36
H2S 35
tryptophan 35
ammonium 34
butyric acid 34
MDR 34
adenosylmethionine 34
chloroform 34
NADPH 34
NADPH 34
retinol 33
proline 33
tryptophan 32
tryptophan 32
aldehyde 32
tryptophan 32
uridine 32
DCC 32
A 71 31
caffeine 31
Lea 31
CAT 31
Quercetin 30
TEM 30
Hoechst 33342 30
glutamic acid 30
pyrene 30
Azoxymethane 30
Estrogen 30
carbonate 30
CAT 29
CAT 29
Estrogen 28
kaempferol 28
DMSO 28
formaldehyde 27
FAP 27
more...