Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In our previous study, low expression of
FAM172A
protein was found in
colon cancer
tissues. This research was planned to explore the functions of
FAM172A
gene and examine the mechanisms of its transcriptional regulation. Firstly, flow cytometry showed that
FAM172A
inhibited proliferation and promoted apoptosis and differentiation of
colon cancer
cells. Then through continuous truncation, we identified the minimal functional promoter region of
FAM172A
. Subsequently, we found that STAT1, as a transcription factor, could bind to the minimal
FAM172A
promoter, as evaluated using Chromatin immunoprecipitation (ChIP) and Electrophoreticmobility shift assay (EMSA). The results of Western blot analysis and qRT-PCR indicated that STAT1 was able to upregulate the expression of
FAM172A
. Our results showed that
FAM172A
could suppress proliferation of
colon cancer
cells, and STAT1 could bind to the minimum promoter region of
FAM172A
and upregulated the expression of
FAM172A
. These results may provide advanced insights into the functions of
FAM172A
and its regulatory mechanisms.
...
PMID:FAM172A modulates apoptosis and proliferation of colon cancer cells via STAT1 binding to its promoter. 2667 44
