Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Emerging evidence shows that exocytosis plays a key role in tumor development and metastasis.
Secernin-1
(
SCRN1
) is a novel regulator of exocytosis. Our previous work identified
SCRN1
as a tumor-associated gene by bioinformatics analysis of transcriptomes. In this study, we demonstrated the aberrant overexpression of
SCRN1
at mRNA and protein level in
colon cancer
. We also revealed that overexpression of
SCRN1
was significantly associated with the tumor development and poor prognosis. Experiments in vitro validated that
SCRN1
may promote cancer cell proliferation and secretion of matrix metalloproteinase-2/9 (MMP-2/9) proteins to accelerate tumor progression.
...
PMID:Secernin-1 contributes to colon cancer progression through enhancing matrix metalloproteinase-2/9 exocytosis. 2581 79
