Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The most prevalent malignancy that can occur in the gastrointestinal tract is
colon cancer
. The current treatment options for
colon cancer
patients include chemotherapy, surgery, radiotherapy, immunotherapy, and targeted therapy. Although the chance of curing the disease in the early stages is high, there is no cure for almost all patients with advanced and metastatic disease. It has been found that over-activation of
cyclooxygenase 2
(
COX-2
), followed by the production of prostaglandin E2 (PGE2) in patients with
colon cancer
are significantly increased. The tumorigenic function of
COX-2
is mainly due to its role in the production of PGE2. PGE2, as a main generated prostanoid, has an essential role in growth and survival of
colon cancer
cell's. PGE2 exerts various effects in
colon cancer
cells including enhanced expansion, angiogenesis, survival, invasion, and migration. The signaling of PGE2 via the EP4 receptor has been shown to induce colon tumorigenesis. Moreover, the expression levels of the EP4 receptor significantly affect tumor growth and development. Overexpression of EP4 by various mechanisms increases survival and tumor vasculature in
colon cancer
cells. It seems that the pathway starting with COX2, continuing with PGE2, and ending with EP4 can promote the spread and growth of
colon cancer
. Therefore, targeting the
COX-2
/PGE2/EP4 axis can be considered as a worthy therapeutic approach to treat
colon cancer
. In this review, we have examined the role and different mechanisms that the EP4 receptor is involved in the development of
colon cancer
.
...
PMID:EP4 receptor as a novel promising therapeutic target in colon cancer. 3319 14
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