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Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The correlation among lymphoid cell infiltration (LI), cell-mediated immunity and immunoglobulin-containing cells distribution in the colon cancer was studied in resected materials of 136 patients with colonic cancer. The results were as follows: 1) LI of the colon cancer tended to be found more commonly in patients with colonic cancer in clinical early stage than advanced stage. 2) The cumulative 5-year survival rate in patients with positive LI was longer than that in the patients with negative or normal LI. 3) In colonic cancer patients with the better prognosis, IgA-containing cells were distributed around the tumor tissues more abundantly than that in the poor ones. 4) These results suggest that the IgA system somewhat participates in cancer immunity.
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PMID:[Histology and immunopathology of colonic carcinoma]. 239 58

The surgical specimens from forty-two patients with colorectal cancer were studied by the immunoperoxidase method for immunoglobulin (Ig); the number of Ig containing cells and round cells within the lamina propria adjacent to the tumor was calculated. The results were as follows; 1) Population per 0.025 mm2 of IgA, IgM, IgG containing cells in the adjacent part to the tumor were 15.5 +/- 0.9, 13.6 +/- 1.4, 8.9 +/- 0.4, respectively. 2) IgA containing cells in the adjacent part to the tumor decreased in number compared with the histologically normal part, while IgG containing cells were more frequently observed in the adjacent part. The differences were statistically significant (p less than 0.05). 3) The number of IgG containing cells was closely related to the size of the tumor, and IgM containing cells was in proportion to the presence of the lymph node metastasis. 4) The number of IgG containing cells in the adjacent part differed significantly between rectal cancer and colon cancer; the number being fewer in rectal cancer. 5) The round cells within the adjacent part increased in number, compared to the histologically normal part, and were observed to be more numerous in the localized ulcerative type of cancer than in the invasive ulcerative type. From these results it could be concluded that Ig containing cells play an important role in the local immunity of colorectal cancer.
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PMID:[An immunohistological study of local immunity of colorectal cancer]. 268 98

Leukocyte adherence inhibition-cell mediated immunity (LAI-CMI) studies were performed on leukocytes obtained from patients with various stages of breast cancer, colon carcinoma and lung cancer in order to monitor cell mediated immunity during tumor progression. In the presence of autologous serum, all patients with localized tumors showed positive LAI-CMI indexes (greater than 20%), while significant reduction of homologous tumor antigen recognition as measured by the LAI-CMI responses was observed in nearly all patients with Stage IV breast cancer, Duke C colon cancer and Stage III lung cancer. On substituting autologous serum with normal AB serum, leukocytes from patients with large tumor burdens responded to homologous tumor antigens. These results indicate the existence of organ-specific serum factor(s) which may mask the receptor sites on effector cells for tumor recognition. Patients with such serum blocking factor(s) showed significant increase of IgG immune complexes IgM, IgA and alpha-2-macroglobulins. Application of a protein A affinity column purification resulted in a major reduction of IgG and other immune globulins but not of alpha-2-macroglobulin. The blocking effects of autologous serum, however, were not completely abrogated by filtration on the protein A column, thus suggesting that SBF may be heterogeneous in nature and may occur in other serum protein fractions beside the immune globulins.
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PMID:Effector lymphocyte response to homologous tumor antigens in various stages of malignant disease as monitored by leukocyte adherence inhibition--cell mediated immunity (LAI-CMI). 328 Apr 78

Two Crohn's disease tissue-specific proteins are identified and purified several thousand-fold from crude tissue extracts by different chromatographic procedures. The two proteins migrate in sodium dodecyl sulfate-polyacrylamide gel electrophoresis as 200-210-kilodalton and 150-160-kilodalton species. They are glycoproteins, as evidenced by their binding to concanavalin A-Sepharose 4B and positive staining with Schiff's reagent. Specific immunoreactivity of the two glycoproteins against Crohn's disease sera was demonstrated by immunotransblot analysis. All but one of the operative specimens of colon or small intestine (or both) from 13 patients with Crohn's disease contained either or both of the proteins; they were not detected in specimens of colon from 5 patients with ulcerative colitis, 1 patient with diverticulitis, 1 patient with ischemic colitis, from the normal bowel segments resected from 3 patients with colon cancer, and from two normal ileal tissue specimens. The two glycoproteins did not react with antihuman IgG, IgM, and IgA, suggesting that they are not immunoglobulins. The purified glycoproteins may provide important leads toward the understanding of the pathogenesis of Crohn's disease.
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PMID:Isolation and characterization of Crohn's disease tissue-specific glycoproteins. 352 40

A double antibody enzyme-linked immunosorbent assay (ELISA) was developed to quantitate circulating immune complexed IgA (IgA IC) in human serum. The serum panel for this study consisted of normal blood donors, benign surgery (BS), head and neck cancer (HN), nasopharyngeal carcinoma (NPC), lung cancer (LC), and colon cancer (CC) patients. Immune complexes (IC) were isolated from these sera by precipitation with 3.5% polyethylene glycol (PEG), washed and then redissolved in 0.1 M phosphate-buffered saline pH 7.2. The amount of IgA IC present were then quantified using the double antibody IgA ELISA. This assay was found to be both sensitive (26.0 ng/ml) and reproducible (intra-assay coefficient of variation 4.0%). The mean IgA IC for each cancer group tested (HN = 11.38 +/- 12.54 micrograms/ml; NPC = 13.36 +/- 17.56 micrograms/ml; LC = 17.39 +/- 13.04 micrograms/ml; CC = 26.50 +/- 4.60 micrograms/ml) were significantly elevated (P = 0.001) over both the normals (5.12 +/- 4.09 micrograms/ml) and the benign surgery controls (5.92 +/- 5.04 micrograms/ml). In addition to providing a new tumor marker the presence of high levels of IgA IC in cancer patients could provide a source of tumor-specific antibody as well as antigen and provide reagents to study immune regulation in cancer patients.
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PMID:Circulating IgA immune complexes in head and neck cancer, nasopharyngeal carcinoma, lung cancer, and colon cancer. 382 45

Plasma exchange was performed in patients with recurrent colon cancer with evaluable liver metastasis or abdominal tumor with dissemination. This therapy was undertaken a total of 19 times in 11 cases. The cases were divided into effective and ineffective cases according in terms of the clinical effects, and changes in blood parameters and prognosis were examined in each case. Subjective symptoms, such as increase in appetite and disappearance of general fatigue or pain, were remarkably improved in 6 cases, and these patients were allowed to be discharged from the hospital. Marked regression of hepatomegalia was observed in 2 cases out of these 6 cases, but no remarkable effect was noted in patients with abdominal dissemination. In the effective cases the following parameters were significantly improved; beta- and gamma-globulin of serum protein fractions, IgG, IgA and IgM of immunoglobulin, alpha 2-macroglobulin, ceruloplasmin, and transferrin. However, since these effects are temporal and short-lived, one must consider applying plasma exchange therapy in conjunction with anticancer drugs, and the like. Plasma exchange seems applicable to cases of colon cancer with metastasis in the liver, because this therapy showed improvement in clinical symptoms, decreased hepatomegaly and prolonged survival.
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PMID:[Clinical trials of plasma exchange therapy in patients with recurrent colon cancer]. 643 4

Three electrophoretically atypical creatine kinase (CK) bands were found simultaneously in the serum of a patient with terminal carcinoma of the colon. The atypical CKs were found at the cathodal side of CK-MB (CK-X1), at a sample application point (CK-X2), and at the anodal side of CK-MM (CK-X3) on agar plates. Our data seemed to suggest that CK-X1 was predominantly a CK-IgA/beta-lipoprotein complex, CK-X3 was a CK-IgG complex, and CK-X2 was macromolecular, different from both CK-X1 and CK-X3. The light chains of IgA and IgG were both of the lambda type. All native isoenzymes comprising these atypical CKs were identified as MM type. There was no change of the electrophoretic pattern of serum CK isoenzymes throughout the course of the study.
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PMID:Three atypical serum creatine kinases in a patient with carcinoma of the colon. 723 28

A human colon cancer cell line CaCo-2 differentiates spontaneously by expressing enterocytic phenotypes after the confluence of the culture. The authors examined a production of secretory components (SC) by CaCo-2 in relation to its differentiation. The SC production showed an increase immediately after the cells came to confluence, and reached its peak production during the 6th to the 9th day after confluence of the culture. SC production decreased remarkably after the 10th day. On the other hand, the activity of alkaline phosphatase of CaCo-2 showed a gradual increase up to the 18th day after confluence. The production of SC was not affected by the presence of dimeric IgA in the culture. Interferon-gamma enhanced SC production of CaCo-2 with dose-dependent manner. These observations indicate that capability of SC production of CaCo-2 is enhanced in the early stage of differentiation but is reduced in the late stage. Moreover, CaCo-2 provides a useful model for studying the regulation of SC production in enterocytic differentiation.
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PMID:The human colon cancer cell line CaCo-2 produces secretory components during enterocytic differentiation. 837 26

A 65-year old man presented with complaints of sclerosis of skin and numbness in the extremities. During last 10 year, he had developed monoclonal gammopathy, Raynaud's phenomenon, ischemic heart disease, sigmoid colon cancer, hyperkalemia, polyneuropathy and scleroderma-like skin changes. Laboratory examinations revealed a monoclonal protein (IgA-lambda) and an elevated serum level of IL-6. Subsequently a diagnosis of POEMS syndrome was made based on the clinical features and laboratory findings which were characteristic of this syndrome. Further examinations showed the presence of glomerulonephritis and brain tumor. These various complications are of great interest in understanding the pathogenesis of POEMS syndrome.
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PMID:[A case of POEMS syndrome with various complications]. 881 May 50

Mutated p21 ras protein contains single substituted amino acid residue. It can be considered as cancer-specific protein. The current study examined whether T-cell and Ab responses to mutant p21 ras protein and/or peptide can be detected in patients with pancreatic or colon cancer. Studies focused on the aspartic acid substitution in amino acid position 12(ras D12) as the commonest mutation in gastrointestinal malignancy. IgA antibodies directed against mutated ras D12 protein were detected in 51 of 160 (31.8%) colon cancer patients, but only in 1 of 40 (2.5%) normals. The greater incidence of antibody in cancer patients provides evidence that immunization to the ras proteins occurred as a result of the malignancy. Seven of sixteen (43.7%) pancreas cancer patients responded to ras D12 peptide. T cell responses to ras D12 peptides were detected in only 2 of 25 (8.0%) colon cancer patients. None of the 11 normal individuals tested had positive responses to normal or mutant ras p21 proteins and/or peptides. Thus, Ab and CD4+ T cell immunity to the mutated segment of ras protein is present in some patients with gastrointestinal cancer.
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PMID:[CD4+ T-cell immunity and Ab responses to mutant ras protein in pancreas and colon cancer patients]. 938 47


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