Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
RBP7
is a member of the cellular retinol-binding protein (CRBP) family and previous data suggested a link between CRBPs and the malignant transformation of
colon cancer
cells. Here, we investigated the potential of
RBP7
as a predictive biomarker for patients with
colon cancer
and determined its functional relevance for tumor progression. We analyzed RBP7 protein and mRNA expression in independent tissue collections of colon cancers with recorded follow-up data, including data from TCGA. We used gene set enrichment analyses to characterize its functional role. Effects of
RBP7
on migration and invasion were determined in transwell assays. High expression of
RBP7
was an independent biomarker of poor cancer specific survival in early and late stage
colon cancer
, and linked to
colon cancer
progression. Gene set enrichment analysis revealed a strong association of
RBP7
,
colon cancer
invasion and epithelial mesenchymal transition (EMT). Ectopic expression of
RBP7
increased migration and invasion of
colon cancer
cells. Our findings demonstrate that
RBP7
is a strong prognostic biomarker in
colon cancer
that functionally contributes to the malignant phenotype of
colon cancer
cells. This may aid in risk stratification for the therapeutic management of patients with colorectal cancer.
...
PMID:RBP7 is a clinically prognostic biomarker and linked to tumor invasion and EMT in colon cancer. 3159 60
