Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Several Butyrophilin (BTN) and Btn-like (BTNL) molecules control T lymphocyte responses, and are genetically associated with inflammatory disorders and cancer. In this study, we present a comprehensive expression analysis of human and murine
BTN
and
BTNL
genes in conditions associated with intestinal inflammation and cancer. Using real-time PCR, expression of human
BTN
and
BTNL
genes was analyzed in samples from patients with ulcerative colitis, irritable bowel syndrome, and colon tumors. Expression of murine
Btn
and
Btnl
genes was examined in mouse models of spontaneous colitis (
Muc2
-/-
) and intestinal tumorigenesis (
Apc
Min/+
). Our analysis indicates a strong association of several of the human genes with ulcerative colitis and
colon cancer
; while especially
BTN1A1
,
BTN2A2
,
BTN3A3
, and
BTNL8
were significantly altered in inflammation, colonic tumors exhibited significantly decreased levels of
BTNL2
,
BTNL3
,
BTNL8
, and
BTNL9
as compared to unaffected tissue. Colonic inflammation in
Muc2
-/-
mice significantly down-regulated the expression of particularly
Btnl1
,
Btnl4
, and
Btnl6
mRNA, and intestinal polyps derived from
Apc
Min/+
mice displayed altered levels of
Btn1a1
,
Btn2a2
, and
Btnl1
transcripts. Thus, our data present an association of
BTN
and
BTNL
genes with intestinal inflammation and cancer and represent a valuable resource for further studies of this gene family.
...
PMID:Altered expression of Butyrophilin (
BTN
) and BTN-like (
BTNL
) genes in intestinal inflammation and colon cancer. 2795 27
