Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Like many epithelial-derived cancers,
colon cancer
results from a multistep tumorigenic process. However, the detailed mechanisms involved in
colon cancer
formations are poorly characterized. In the present study, we investigated the role of
RTKN
in
colon cancer
and explored underlying mechanisms. The results showed that
RTKN
expression was significantly increased in
colon cancer
tissues when compared with the adjacent tissues of patients in Shanghai People's hospital and in TCGA independent dataset. Furthermore, silencing of
RTKN
inhibited cell proliferation, migration, invasion, and arrested cell cycle at G1 phase in LOVO cells. Bioinformatics analysis demonstrated that DNA replication and cell cycle were involved in the regulation of
RTKN
. MCM2/3/5, CDK1/2 and PCNA expression had a direct relationship with the reduction of
RTKN
.
RTKN
could affect the proliferation and metastasis of
colon cancer
by reducing expression of MCM2/3/5, CDK1/2 and PCNA, suggesting that
RTKN
was a potential target for treating
colon cancer
.
...
PMID:Effect of RTKN on progression and metastasis of colon cancer in vitro. 2634 72
