Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In recent years it has become more and more apparent that the regulation of gene expression by RNA-binding proteins (RBPs) is of utmost importance for most cellular signaling pathways. RBPs control several aspects of RNA biogenesis including splicing, localization, stability, and translation efficiency. One of these RBPs is
RBM47
that recently has been suggested to function as a tumor suppressor as it was shown to suppress breast and
colon cancer
progression. Here we demonstrate that
RBM47
is an important regulator of basal and DNA damage-induced p53 and p21
WAF1/CIP1
protein expression. Knockdown of
RBM47
by siRNAs results in a strong reduction in p53 mRNA and protein levels due to an impaired p53 promoter activity. Accordingly, overexpression of Flag-
RBM47
enhances p53 promoter activity demonstrating that
RBM47
regulates p53 at the transcriptional level. By controlling p53, knockdown of
RBM47
concomitantly decreases also p21 expression at the transcriptional level, driving irradiated carcinoma cell lines from different entities into cell death rather than into senescence. Thus,
RBM47
represents a novel molecular switch of cell fate decisions that functions as a regulator of the p53/p21-signaling axis.
...
PMID:The RNA-binding protein RBM47 is a novel regulator of cell fate decisions by transcriptionally controlling the p53-p21-axis. 3151 50
