Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Many patients who present with chronic diarrhea are not found to have an important organic disease. Most will have "functional" diarrhea. The history, the physical examination and the initial laboratory tests should lead to a provisional diagnosis, with respect to the organic or functional origin, and the location of disease in the small or the large bowel. Specific tests are then done to define particular organic causes of which malabsorption, inflammatory bowel diseases, carcinoma of the large bowel, parasitic infections, and metabolic disorders are most common. Patients with suspected functional diarrhea should be investigated at least by stool analysis, proctosigmoidoscopy, and barium enema. Functional diarrhea is common and these patients are no less susceptible to severe disease than is the rest of the population.
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PMID:Chronic diarrhea. A practical approach. 34 Aug 15

Two patients with colonic adenocarcinoma and Streptococcus bovis endocarditis suggested a possible association between the two. Non-enterococcal Group D streptococci were isolated from fecal cultures of 11 of 105 controls, 35 of 63 patients with carcinoma of the colon, seven of 25 with inflammatory bowel disease, four of 21 with non-colonic neoplasms and five of 37 with other gastrointestinal disorders. All such streptococci examined for lactose fermentation were S. bovis. The prevalence of S. bovis in fecal cultures from patients with carcinoma of the colon was significantly increased (P less than 0.001) as compared to that in controls, and also to all other groups (P less than 0.001). No other group had results significantly different from those of controls (P less than 0.05) although patients with inflammatory bowel disease were more frequently carriers. The carrier state was unrelated to age, hospitalization status, colonic stasis, gastrointestinal bleeding or recent barium-enema examination. The implications of this association are unknown.
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PMID:Association of Streptococcus bovis with carcinoma of the colon. 40 87

Twenty-four patients with chronic ulcerative colitis and colon carcinoma who underwent barium enema examination prior to the diagnosis of cancer were studied in an attempt to correlate the radiographic appearance of the tumors with their biologic behavior, as well as to assess the accuracy of the barium enema in detection. Of the radiographically detected tumors, 65% displayed an annular infiltrative appearance, with the prime radiographic manifestation being relative nondistensibility of the involved segment. The remaining tumors had various appearances more typical of noncolitic colon cancer. Patients with infiltrative lesions had a much poorer prognosis than those with noninfiltrative lesions. Of 33 gross tumors described pathologically and/or surgically, only 70% were correctly detected by barium enema. It is suggested that periodic barium enema examinations are an unreliable means of following patients with ulcerative colitis if malignant degeneration is to be detected at an early and curative stage. Prophylactic proctocolectomy may be the best therapeutic approach.
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PMID:Chronic ulcerative colitis and colon cancer: can radiographic appearance predict survival patterns? 41 78

Two cases of irradiation-associated carcinoma of the colon are reported and the literature reviewed. The clinical courses and operative difficulties in treating these patients are emphasized. The necessity for life-long follow-up examinations with proctoscopic and barium-enema evaluations in high-risk patients is stressed. Irradiation-associated carcinoma of the colon occurs almost exclusively in women, but should be investigated in patients of either sex who live for long periods after pelvic irradiation.
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PMID:Late development of colorectal cancer subsequent to pelvic irradiation. 42 78

The technical progress in the development of the fiber coloscopy gives the possibility to inspect the whole large intestine including the terminal ileum. The essential contribution of the coloscopy consists in the early diagnosis of the carcinoma of the large intestine. The malignant change of the polyp may be proved or excluded only after total polypectomy. In our clinical material consisting of 250 patients in 44% of the cases the total coloscopy confirmed the radiological suspicion. In 38% of the cases the pathological changes of the large intestine could be excluded, and a laparotomy was unnecessary. In 18% another severe finding of the large intestine was established. In haemorrhage of the large intestine of unclear genesis the coloscopy made possible the final recognition of the source of haemorrhage in 92% of the cases. In patients with colitis we established coloscopically larger changes than could be assumed on the basis of the barium enema. The total coloscopy given a highest possible certainty in the diagnostics of the large intestine.
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PMID:[Serology of toxoplasmosis in patients with lymphogranulomatosis]. 53 6

An abnormal zone of DNA synthesis at the surface and upper portion of colonic crypts has been thought to be related to future adenomatous polyp development and to express a regulatory defect in the mechanism that normally terminates synthesis in the upper third. As part of a screening program for early colon cancer detection, patients over 40 years of age found to have occult blood in their stool (Ho+) are evaluated by barium enema and colonscopy as well as isotopic incorporation studies of biopsy and lavage specimens. This proliferative abnormality occurred most frequently among patients with an adenoma or adenocarcinoma although the frequency varied among simultaneous biopsies from the same patient. Specimens from Ho+ patients with a tumor often contained small areas of focal atypism in the biopsy or fragments of atypical epithelial cells in the lavage sample. A small group of Ho+ patients in whom no overt neoplasm could be detected also demonstrated surface-labeled epithelial cells with morphological alteration of these cells. Based on the microscopic findings presented, continued surveillance of these patients is suggested, as well as extension of these studies to include other high risk groups.
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PMID:Early detection of colonic neoplasia in patients at high risk. 59 71

Two cases of ischemic colitis occurring proximal to carcinoma of the colon are described, with special reference to the barium enema and pathological findings. The association of these two conditions is rare but when present may cause some confusion. It is possible that the two lesions may, for instance, be considered to be both due to ischemic colitis, or mistaken for granulomatous colitis with a stricture.
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PMID:Ischemic colitis associated with carcinoma of the colon. 61 99

A symptomatic hernia (most inguinal or femoral hernia, seldom epigastric, umbilical or post-operative hernia)--appeared a little while ago--originates from a preexisting, so far unknown or long since known illness. All patients with a hernia--especially those over 40 years old--are to be carefully asked for preexisting illnesses. Barium-enema and rectoscopy are not indicated at each inguinal or femoral hernia as a screening-method to exclude a symptomatic hernia; however, both methods must be employed in suspicious cases. 320 Patients with a histologically verified carcinoma of the rectum and colon had no inguinal or femoral hernia. From 387 patients with an inguinal or femoral hernia 318 patients were over 40 years old; at these patients polyps were found in five cases by rectoscopy, but never by barium-enema, and two carcinoma of the colon transverse appeared by barium-enema. A 23-years old patient with a great intraabdominal malignant tumor must be added to the sum total.
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PMID:[Symptomatic hernia (author's transl)]. 62 60

In 3 patients with carcinoma of the colon, lesions were seen as linear shadows on air-contrast barium enema studies. When the elevation of a lesion is slight or the tumor--mucosal interface is gently sloping, the tumor's proximal and distal edges may be ill-defined or disappear altogether. Thus only a linear shadow representing the interface between the tumor surface and air in the lumen appears. Other causes of these lines are also discussed.
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PMID:Linear shadows in the air-contrast barium enema. 66 47

The purpose of this presentation is to point out the importance of this new diagnosis and treatment method, recently incorporated. The studies were done with the Fibroscope F9-A with doble channel, equipped with an desection smear for polipectomies and an extracting forceps. The patients arrive with their intestine perfectly cleaned with classical methods. This detail is most important for the polipectomies. If the local conditions aren't the desired, presence of bowels or barium of an previous enema, we postpone both, examination and polipectomy, because those are causes of false diagnosis in the first case or eventual accidents in the second condition. Regarding this, we had an performing doing a biopsy in an stenosing neoplasm of the sigmoid colon. We believe it convenient to prevent this complication, to reduce the air pressure before performing the biopsy. Of the 160 patients examinated, 54 had no patology, 32 had polips and of this group 4 had multiple poliposis, 4 had association with diverticulosis and 3 associated with neoplasm. (4 were neoplasm, 10 stenosis without mucous lesions, 1 villous adenoma, 1 megacolon and 1 rectitis). We made 12 polipectomies, 10 with the conventional technique and 2 associated with surgery. We had no accidents and one of them was an early stage of colon cancer.
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PMID:[Personal experience in colonoscopy and polypectomy]. 74 24


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