Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
[VO(Sal-
L
-tryp)(H
2
O)]
1
(where sal-
L
-tryp =
N
-salicylidene-
L
-tryptophanate) was used as a precursor to produce the novel complexes, [VO(Sal-
L
-tryp)(MeATSC)].1.5C
2
H
5
OH
2
(where MeATSC =
9-Anthraldehyde
-N(4)-methylthiosemicarbazone), [VO(Sal-
L
-tryp)(
N
-Ethhymethohcarbthio)].H
2
O
3
(where
N
-Ethhymethohcarbthio = (
E
)-
N
-ethyl-2-(4-hydroxy-3-methoxybenzylidene)hydrazinecarbothioamide), and [VO(Sal-
L
-tryp)(acetylethTSC)].C
2
H
5
OH
4
(where acetylethTSC = (
E
)-
N
-ethyl-2-(1-(thiazol-2-yl)ethylidene)hydrazinecarbothioamide), by reaction with the respective thiosemicarbazone. The chemical and structural properties of these ligands and complexes were characterised by elemental analysis, ESI MS, FT-IR, UV-visible, ESR,
1
H and
13
C NMR spectroscopy, and X-ray crystallography. DMSO and DMSO-d
6
solutions of compounds
1-4
were oxidised in air to produce vanadium(V) species which were verified by ESI MS and
51
V NMR spectroscopy. Anti-cancer properties of compounds
2-4
were examined with three
colon cancer
cell lines, HTC-116, Caco-2, and HT-29, and also with non-cancerous colonic myofibroblasts, CCD18-Co. Compounds
2-3
exhibited less inhibitory effects in the CCD-18Co cells, indicating a possible cytotoxic selectivity towards
colon cancer
cells. In general, those compounds which exhibited anti-proliferative activity on cancer cells, but did not affect non-cancerous cells, may have a potential in chemotherapy.
...
PMID:Synthesis, characterization, and preliminary
in vitro
studies of vanadium(IV) complexes with a Schiff base and thiosemicarbazones as mixed-ligands. 2390 89
