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Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Xanthatin
is a natural plant bicyclic sesquiterpene lactone extracted from
Xanthium plants (Asteraceae).
In the present study, we demonstrated for the first time that
Xanthatin
inhibited cell proliferation and mediated G
2
/M phase arrest in human
colon cancer
cells.
Xanthatin
also activated caspase and mediated apoptosis in these cells. Concomitantly,
Xanthatin
triggered cell autophagic response. We found down-regulation of X-linked inhibitor of apoptosis protein (XIAP) contribute to the induction of apoptosis and autophagy. Moreover, reactive oxygen species (ROS) production was triggered upon exposure to
Xanthatin
in
colon cancer
cells. ROS inhibitor N-acetylcysteine (NAC) significantly reversed
Xanthatin
-mediated XIAP down-regulation, G
2
/M phase arrest, apoptosis and autophagosome accumulation. In summary, our findings demonstrated that
Xanthatin
caused G
2
/M phase arrest and mediated apoptosis and autophagy through ROS/XIAP in human
colon cancer
cells. We provided molecular bases for developing
Xanthatin
as a promising antitumor candidate for
colon cancer
therapy. AbbreviationsROSreactive oxygen speciesDMSOdimethyl sulfoxide5-FU5-Fluorouracil3-MA3-MethyladenineDCFH-DA2'7'-dichlorfluorescein-diacetateNACN-acetylcysteineXIAPX-linked inhibitor of apoptosis protein.
...
PMID:Xanthatin mediates G
2
/M cell cycle arrest, autophagy and apoptosis via ROS/XIAP signaling in human colon cancer cells. 3058 55
