Gene/Protein
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Drug
Enzyme
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Gene/Protein
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Drug
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Target Concepts:
Gene/Protein
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Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Several Butyrophilin (BTN) and Btn-like (BTNL) molecules control T lymphocyte responses, and are genetically associated with inflammatory disorders and cancer. In this study, we present a comprehensive expression analysis of human and murine
BTN
and
BTNL
genes in conditions associated with intestinal inflammation and cancer. Using real-time PCR, expression of human
BTN
and
BTNL
genes was analyzed in samples from patients with ulcerative colitis, irritable bowel syndrome, and colon tumors. Expression of murine
Btn
and
Btnl
genes was examined in mouse models of spontaneous colitis (
Muc2
-/-
) and intestinal tumorigenesis (
Apc
Min/+
). Our analysis indicates a strong association of several of the human genes with ulcerative colitis and
colon cancer
; while especially
BTN1A1
,
BTN2A2
,
BTN3A3
, and
BTNL8
were significantly altered in inflammation, colonic tumors exhibited significantly decreased levels of
BTNL2
,
BTNL3
,
BTNL8
, and
BTNL9
as compared to unaffected tissue. Colonic inflammation in
Muc2
-/-
mice significantly down-regulated the expression of particularly
Btnl1
,
Btnl4
, and
Btnl6
mRNA, and intestinal polyps derived from
Apc
Min/+
mice displayed altered levels of
Btn1a1
,
Btn2a2
, and
Btnl1
transcripts. Thus, our data present an association of
BTN
and
BTNL
genes with intestinal inflammation and cancer and represent a valuable resource for further studies of this gene family.
...
PMID:Altered expression of Butyrophilin (
BTN
) and BTN-like (
BTNL
) genes in intestinal inflammation and colon cancer. 2795 27
Immunogenomics studies of
colon cancer
have lagged behind other cancer types, such as melanoma and lung cancer, potentially limiting immunotherapy approaches to
colon cancer
, also less common than in the cases of melanoma and lung cancer. Here we applied an extensively benchmarked algorithm for retrieving immune receptor recombination sequencing reads from
colon cancer
exomes available via the cancer genome atlas. Assessment of the complementarity determining region-3 chemical features represented by the reads revealed associations of distinct chemical features with better or worse survival rates, for both T-cell and B-cell receptor, recombination reads. A follow up assessment of immune gene expression correlations with the recovery of the recombination reads revealed a consistent association of high level expression of
BTN
gene family members and better survival rates. Overall, these approaches provide several striking consistencies connecting immunogenomics features with
colon cancer
survival rates, potentially providing a basis for guiding immuno-therapy applications.
...
PMID:Immunogenomics of colorectal adenocarcinoma: Survival distinctions represented by immune receptor, CDR3 chemical features and high expression of BTN gene family members. 3276 37
