Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Circulating levels of carcinoembryonic antigen (CEA) and glucose phosphate isomerase (GPI) have been measured and compared in 51 subjects with gastric and colonic diseases. Levels were higher in gastric and colonic cancer patients than in normals or patients with other diseases. Elevations of both these markers were most frequent in patients with metastases. Concentrations of CEA and GPI in gastrointestinal washings were also measured. No correlation was found between total protein content and concentrations of CEA or GPI in the washings. Further characterization of the perchloric acid-soluble material from colon washings by gel filtration indicated that the CEA-like substance from colon cancer patients was higher in molecular weight than standard radiolabeled CEA and CEA from normal colon washings. When tested against anti-CEA antiserum and pure CEA from a colonic cancer metastasis, all CEA preparations showed immunological identity in gel-diffusion plates; on immunoelectrophoresis similar mobility was indicative of a similar charge.
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PMID:Quantitation and immunochemical characterization of carcinoembryonic antigen and glucose phosphate isomerase in blood and washings of patients with gastric and colonic diseases. 61 27

Carcinoembryonic antigen and activities of glucosephosphate isomerase (EC 5.3.1.9), gamma-glutamyltransferase (EC 2.3.2.2), and lactate dehydrogenase (EC 1.1.1.27) were measured in aqueous extracts of fetal, normal adult, and malignant human colon tissues. Fetal colon, as well as primary and metastatic colon tumor tissue, showed higher activities of these analytes than did normal adult human colon. Liver metastases of colon cancer gave the highest values, normal adult human colon the lowest. Statistically, these differences were more striking in the case of carcinoembryonic antigen and glucosephosphate isomerase than for gamma-glutamyltransferase or lactate dehydrogenase. In contrast to the other markers, gamma-glutamyltransferase activity was lower in fetal organs than in normal adult colon and colon tumors. These results are consistent with earlier observations that activities of these markers are significantly increased in the blood of patients with metastatic colon cancer.
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PMID:Concurrent measurements of carcinoembryonic antigen, glucosephosphate isomerase, gamma-glutamyltransferase, and lactate dehydrogenase in malignant, normal adult, and fetal colon tissues. 610 67