Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We developed a smart activity-based probe that detects the activity of
asparaginyl endopeptidase
(
AEP
) in live cells to monitor the dynamics of enzyme regulation. The newly designed probe generated a turn-on fluorescence signal in response to the activity of
AEP
in living cells without compromising the labelling efficiency or selectivity. Our probe closely reflected the enzyme activity in its native state, detecting subcellular
AEP
activity in
colon cancer
cells and neuronal cells.
...
PMID:Development of a smart activity-based probe to detect subcellular activity of asparaginyl endopeptidase in living cells. 2892 Jan 16
