Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neoplastic transformations are accompanied by an alteration in the composition of cell membrane glycoproteins, major structural components of the cell surface. Plasma sialyltransferase enzyme is involved in the transfer of sialic acid residues from cytosine monophosphate (CMP) sialic acid to a suitable acceptor. In the present study plasma sialyltransferase was assayed using a radiometric method, which measured the transfer of radioactivity from (14C) CMP sialic acid to desialated fetuin. Plasma sialyltransferase was measured in 127 normal and 91 cancer patients. The mean plasma sialyltransferase in the normal volunteers was 837 units (CPM/25 microliters plasma/hr). The mean plasma sialytransferase in 26 breast cancer patients, 22 lung cancer patients, 20 colon cancer patients, 5 ovarian cancer patients, 4 cervix cancer patients, 5 pancreas cancer patients, 6 prostate cancer patients, and 3 gastrointestinal tract cancer patients was 1710, 1406, 1344, 1227, 1233, 1406, 1250, and 1426 units, respectively. No significant difference was observed with respect to age. In 32 treated breast cancer patients the mean value was 757 units. Serial determinations in 17 patients correlated well with tumor burden. However, in 2 patients the plasma enzyme level did not correspond to tumor mass. These results indicate that plasma sialyltransferase is significantly elevated in patients with a variety of cancers. Plasma sialyltransferase determination may be useful in the followup of patients with a variety of cancers.
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PMID:Plasma sialyltransferase as a tumor marker. 339 Aug 43

The whole blood monocyte count (WBMC), migratory response (MMR), phagocytic index (MPI), chemiluminescence (MCL) and serum opsonic activity (SOA) were measured in a group of 31 patients before and after undergoing elective operation for carcinoma of the colon and rectum (group 1). In the early postoperative period, there was a reduction of the WBMC (preoperatively: 54.1 +/- 41.8, 24 hours; 38.4 +/- 24.8, 48 hours, and 39.1 +/- 24.2 X 10(4) per milliliter, both p less than 0.05), impairment of MMR (preoperatively, 72.2 +/- 34.4; 24 hours, 56.7 +/- 28.6, and 48 hours, 54.7 +/- 30.8 cells per high power field [HPF], both p less than 0.01), enhancement of the MPI (preoperatively, 208.1 +/- 44.1, 24 hours, 225.9 +/- 45.6, p less than 0.05, and 48 hours, 242.0 +/- 48.0, p less than 0.01) and an increase of the MCL (preoperatively, 26,091 +/- 14,419; 24 hours, 30,896 +/- 13,741, and counts per minute [CPM], not significant and 48 hours: 33,576 +/- 18,167 CPM, p less than 0.02). There was also a small reduction in monocyte SOA during this period (preoperatively, 89.4 +/- 13.9; 24 hours, 83.0 +/- 20.1, and 48 hours, 78.3 +/- 29.3 per cent control, both p less than 0.05). At one week after operation, monocyte function tended to return to the normal range in patients who had undergone uncomplicated curative resection. These functions tended to be increased in those patients with complications. The administration of the immunostimulant levamisole (5 milligrams per kilogram) preoperatively to a group of 20 patients with carcinoma of the colon and rectum (group 2) did not result in any significant differences of the postoperative monocyte functions when compared with the patients in group 1.
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PMID:The effect of surgical procedures on monocyte function in patients with carcinoma of the colon and rectum. 375 Jan 79

Invasive colon adenocarcinomas with lymph node metastases can be induced in Sprague-Dawley rats by 15 weekly intrarectal injections of 2 mg N-methyl-N-nitrosourea (NMU). Extracts were prepared from invasive adenocarcinomas and normal rat colon mucosa by a 2 phase gradient. Mixed leukocyte tumor interaction (MLTI) assays stimulating lymphocytes from tumor-bearing and normal rats were performed using these extracts. Quadruplicate cultures were established with 2 X 10(5) lymphocytes and tumor or normal colon extract. Cultures were pulsed with H3 thymidine at 7 days and harvested 6 hours later. Results were expressed as net counts (experimental CPM minus background CPM). Reactivity in tumor-bearing animals was first seen when rat colons showed intraepithelial dysplasia histologically and was maximal when early invasive colon tumors were present. No difference in stimulation was seen between tumor-bearing and normal animal lymphocyte reactivity with normal colon extract. In conclusion, animals with NMU-induced rat colon cancer show specific tumor reactivity in MLTI assays. Immune reactivity in these animals may provide clues to clinical tumor status by immunologic assay.
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PMID:Tumor specific reactivity during development of N-methyl-N-nitrosourea-induced rat colon cancer. 622 94