Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fluorouracil (Adrucil) has been used for more than 20 years to treat metastatic colorectal carcinoma and has provided significant palliation of symptoms to some patients. Investigators are attempting to exploit pharmacologic aspects of fluorouracil that will provide further benefits. Prolonged infusion of the drug appears to overcome the problems of its brief half-life and the small percentage of cancer cells that are susceptible to the drug at any one time. The addition of leucovorin increases fluorouracil's ability to inhibit thymidylate synthase and thus colon cancer cell replication. It is hoped that the increased response rates produced by these advances will produce increased survival rates as well.
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PMID:Treatment of metastatic colorectal carcinoma. Recent advances in use of fluorouracil. 281 19

Levamisole, a widely used antihelminthic drug has been shown to restore cutaneous delayed hypersensitivity in anergic patients with cancer and to amplify the activation of T lymphocytes by in vitro mitogens. Levamisole has been approved for the treatment of colon cancer in combination with 5 Fluorouracil. Herein we report a case of a 5 1/2 y.o. male who presented with a fulminant, disseminated mycobacterial infection of his joints secondary to a deficiency in his cellular mediated immunity in association with chemotherapy for a T cell leukemia. The patient was treated with Levamisole resulting in restoration of his T cell functions and resolution of his mycobacterial infection.
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PMID:Levamisole as an immunopotentiator for T cell deficiency. 807 2