Gene/Protein
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Drug
Enzyme
Compound
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Target Concepts:
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Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Xanthatin is a natural plant bicyclic sesquiterpene lactone extracted from
Xanthium
plants (Asteraceae).
In the present study, we demonstrated for the first time that Xanthatin inhibited cell proliferation and mediated G
2
/M phase arrest in human
colon cancer
cells. Xanthatin also activated caspase and mediated apoptosis in these cells. Concomitantly, Xanthatin triggered cell autophagic response. We found down-regulation of X-linked inhibitor of apoptosis protein (XIAP) contribute to the induction of apoptosis and autophagy. Moreover, reactive oxygen species (ROS) production was triggered upon exposure to Xanthatin in
colon cancer
cells. ROS inhibitor N-acetylcysteine (NAC) significantly reversed Xanthatin-mediated XIAP down-regulation, G
2
/M phase arrest, apoptosis and autophagosome accumulation. In summary, our findings demonstrated that Xanthatin caused G
2
/M phase arrest and mediated apoptosis and autophagy through ROS/XIAP in human
colon cancer
cells. We provided molecular bases for developing Xanthatin as a promising antitumor candidate for
colon cancer
therapy. AbbreviationsROSreactive oxygen speciesDMSOdimethyl sulfoxide5-FU5-Fluorouracil3-MA3-MethyladenineDCFH-DA2'7'-dichlorfluorescein-diacetateNACN-acetylcysteineXIAPX-linked inhibitor of apoptosis protein.
...
PMID:Xanthatin mediates G
2
/M cell cycle arrest, autophagy and apoptosis via ROS/XIAP signaling in human colon cancer cells. 3058 55
