Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0699790 (colon cancer)
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Male, of 58 years, caucasian, construction worker, non smoker, with depressive syndrome, biliary lithiasis, renal cysts, surgery for benign intestinal polyps and relevant familiar history - aunt with lung cancer and mother with colon cancer. He initiated thorax pain and vomitting and made a chest x-ray, showing a right basal lung mass. During the etiologic study, he was submitted to thoracotomy with biopsy, in April 2006 - "fine granulations, spread for all the pulmonary field", allowing the diagnosis - adenosquamous lung carcinoma, stage IV (16/05/2006). He initiated citostatic treatment with vinorelbine-carboplatin in 02/06/2006, with haematological toxicity and later with neurological toxicity. At that time, he passed to second line treatment with erlotinib, that it was initiated in 11/06/2007, without significant secondary effects. Patient developed trigemic nerve pain, in October/2007, which subsequent study disclosed right esfenopetroclival meningioma, treated with radiosurgery. Later he presented cerebral metastization and erlotinib was discontinued in 09/06/2008. He was submitted to neuroradiosurgery. Now is under symptom support care. Rev Port Pneumol 2008; XIV (Supl 3): S79-S82.
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PMID:Erlotinib in non-small cell lung cancer's second line treatment. Clinical case. 2596 92