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Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-one patients with inoperable colon cancer in the pelvis were treated with intra-arterial 5-fluorouracil (5-FU) and mitomycin C, given bilaterally into the internal iliac arteries. Seventeen of the 21 patients had failed previous radiation therapy and 15 had also failed systemic intravenous chemotherapy. Eighteen of the 21 patients received intra-arterial treatments because of pelvic pain. Effect of this treatment on the pain could be evaluated in 16 patients. A measurable decrease in pain medication occurred in 8 of 16, whereas a subjective feeling of pain relief was observed in 12 of 16 patients for a mean period of 3.5 months. However, objective tumor response was considered definite only if associated with a greater than 50% decline of an elevated plasma carcinoembryonic antigen level; this was observed in 5 of 11 patients (45%). Reduction in tumor mass as measured by imaging techniques was observed in two of ten patients in whom it was evaluable. Improvement in hydronephrosis was observed in five of seven evaluable patients. Hematuria was present in 12 patients and improved in 10 of those patients. The most significant side effect of chemotherapy was perineal and gluteal skin erythema, which was observed in 36% of the patients after the first course and in 24% during the second course. This frequently escalated to cutaneous vesiculation and desquamation. This side effect was prevented by concurrent administration of steroids. Pelvic arterial infusion of 5-FU and mitomycin C can offer temporary pain relief to patients who have failed other means of therapy. Objective antitumor effects may have also resulted but were much harder to assess in this group of patients.
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PMID:Palliation of pelvic recurrence of colorectal cancer with intra-arterial 5-fluorouracil and mitomycin. 299 49

In the last few years, an enormous progress has been achieved in the treatment of Colorectal Cancer due to a better know ledge of the biology, natural history, prevention and treatment of colon and rectum adenocarcinoma. Genetic alterations produce changes in thecolonic mucosa that lead to the formation of adenoma and eventually, its transformation into cancer. At present, it is well established that the Adenomatous Polyp preceeds Colorectal Cancer. The average span of time from normal mucosa to Adenomatous Polyp is about 5 years, and it takes around 5 more years for the Adenomatous Polyp to transform into cancer. The treatment of patients with Colorectal Cancer varies from Endoscopic Polypectomy or formal surgical resection to combined multidisciplinary strategies, according with the stage of the disease. Endoscopic Polypectomy has helped to avoid multiple operations that were performed in the past, it also reduces significantly the development of a second cancer in cured patients who had suffered Colon Cancer. The prognosis of node-negative patients is excellent with a 5 year survival of 80 per cent. Adjuvant chemotherapy has proven to be effective in node-positive Colon Cancer, improving the overall survival. In Rectum Cancer, the use of staplers and changes in the surgical technique have reduced the number of abdominoperineal resections, preserving the annal sphincter and improving the quality of life in patients. Adjuvant chemoradiation control groups and historical controls show a local recurrence of 20-45 per cent in node-positive Rectum Cancer, and 15-30 per cent in node-negative patients. Recently, the improvement of the lateral dissection reduces recurrence in 10 per cent, avoiding pelvic pain, although overall survival has not been improved. Local excision of early lesions from the rectum is an interesting choice in patients who have been carefully selected. We believe that in the following years, the clinical appearance of Colorectal Cancer can be prevented with a better knowledge of its molecular biology.
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PMID:[COLON AND RECTUM CANCER SURGERY] 1227 38

INTRODUCTION. During the last 30 years, the multidisciplinary treatments of colon and uterus neoplasm have yielded an increase in total survival rates, fostering therefore the increase of cases with regional relapse involving the urinary tract. In these cases the iterative surgery can be performed, if no disease secondary to pelvic pain, haemostatic or debulking procedure is present, and must be considered and discussed with the patient, according to his/her general status. MATERIALS AND METHODS. From 1997 to August 2007 we performed altogether 43 pelvic iterative surgeries, with simultaneous urologic surgical procedure because of pelvic tumor relapse in patients with uterus neoplasm and colon and rectal cancer. In 4 cases of anal cancer, the urological procedure were: one radical prostatectomy with continent vesicostomy in the first case, while in the other 3 cases radical pelvectomy with double-barrelled uretero-cutaneostomy. In 23 cases of colon cancer, the urologic procedures were: 9 cases of radical cystectomy with double-barrelled uretero-cutaneostomy, 4 cases of radical cystectomy with uretero-ileo-cutaneostomy according to Bricker- Wallace II procedure, and 9 cases of partial cystectomy with pelvic ureterectomy and ureterocystoneostomy according to Lich-Gregoire technique (7 cases) and Lembo-Boari (2 cases) procedure. In 16 cases of uterus cancer, the urological procedure were: 7 cases of partial cystectomy with pelvic ureterectomy and uretero-cystoneostomy according to Lich-Gregoire procedure; in 3 cases, a radical cystectomy with urinary continent cutaneous diversion according to the Ileal T-pouch procedure; 2 cases of total pelvectomy and double uretero-cutaneostomy, and 4 cases of bilateral uretero-cutaneostomy. RESULTS. No patients died in the perioperative time; early systemic complications were: 2 esophageal candidiasis, 1 case of venous thrombosis. CONCLUSIONS. The iterative pelvic surgery in the case of oncological relapse involving the urinary tract aims to achieve the best quality of life with the utmost oncological radicality. The equation: eradication of pelvic neoplasm and urinary tract reconstruction, with acceptable quality of life, will be the future target; nevertheless, it is not possible to establish guidelines beforehand, and the therapy must be adapted to each single case.
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PMID:[Urologic surgical procedures in patients with uterus neoplasm and colon-rectal cancer]. 2108 75

Impar ganglion is a solitary ganglion located retroperitoneally at the end of paravertebral sympathetic chain and usually in front of sacrococcygeal joint. Solitary or metastatic tumour in the surrounding tissues causes poorly localized pain. This case report presents a 75-year old male patient with colon cancer, whose severe pain during defecation could not be controlled with conventional high-dose opioid application but with transcoccygeal radiofrequency thermocoagulation. Radiofrequency thermocoagulation is promising not only for chronic pelvic pain control but also in pelvic pain secondary to malignancy particularly when the ganglion is localized by radiologic imaging techniques.
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PMID:Impar ganglion radiofrequency application in successful management of oncologic perineal pain. 2525 94

Primary angiosarcoma of the bone (PAB) is a rare and fatal high-grade malignant vascular bone tumor. We report a rare case of multicentric PAB mimicking bone metastasis in a 59-year-old female patient with a history of sigmoid colon cancer. This patient complained of lower back and pelvic pain and presented with multiple osteolytic bone lesions on plain radiography and pelvic computed tomography. First, bone metastasis of sigmoid colon cancer was suspected. However, on the (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) scan, the patient presented unusual multiple hypermetabolic osteolytic bone lesions involving contiguous bones of the lower half of the body. After bone biopsy, these lesions were confirmed to be multicentric PAB. To the best of our knowledge, this is the first case report of an (18)F-FDG PET/CT scan in a patient with multicentric primary bone angiosarcoma.
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PMID:Multicentric Primary Angiosarcoma of Bone Mimicking Metastasis on (18)F-FDG PET/CT in a Patient with a History of Sigmoid Colon Cancer: a Case Report. 2655 53

Ultrasound is a first line imaging modality for the evaluation of female pelvic pain. Pelvic pain constitutes one of the most common reasons for presentation to the emergency department with increasing use of point of care ultrasound. Infrequently, point of care or formal ultrasound evaluation may lead to misdiagnosis of extraovarian disease. This can have serious consequences, especially if an extraovarian malignancy is mistaken for a normal ovary or an ovary with a benign process. We present a case of a 41-year-old female who presented to the emergency department for a chief complaint of pelvic pain and vaginal bleeding. Transvaginal ultrasound demonstrated a left adnexal mass, later characterized as a sigmoid colon cancer on MRI and pathology, simulating ovarian echotexture with peripheral hypoechoic components resembling follicles. This article will review the literature of various cases of extraovarian pathology misidentified as ovarian processes and highlight the importance of considering these extraovarian mimickers to prevent potential morbidity and mortality of a missed diagnosis.
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PMID:Sigmoid cancer mimicking ovarian echotexture on transvaginal ultrasound: Case report with literature review. 3301 34