Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A truncating mutation (C to T transition) at codon 531 of the human protooncogene c-src, possibly accounting for the activation of c-src tyrosine kinase, has been recently identified in a subset of advanced colorectal cancer from North-American patients. However, two subsequent studies have failed to confirm the occurrence of SRC 531 mutation in colorectal cancers from North-European and Asiatic patients, raising the hypothesis that the genetic activation of src in colon cancer might be restricted to patients belonging to specific ethnic groups. We investigated a large series of colorectal cancers from Italian patients (155 cases) with a high prevalence of liver metastasis (43%). Using a PCR-RFLP assay, the occurrence of a SRC 531 mutation was ruled out in all the investigated specimens of primary tumours and/or metastases. Our results demonstrate that SRC Gln531AMB plays no role in the development or in the progression of colorectal cancer among Italian patients.
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PMID:Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patients. 1116 76

We have examined the activity of protein tyrosine phosphatase in various tumor cell lines and surgically resected human colon carcinoma specimens. The protein tyrosine phosphatase activity of rat fibroblasts increases with the transformation by v-src gene. Likewise human colon carcinoma and human neuroblastoma cell lines, in which the activation of c-src tyrosine kinase was reported, show elevated protein tyrosine phosphatase activity in most cases. We compared the protein tyrosine phosphatase activity of eight human colon cancer tissues with that of normal mucosa of the same patient. The results show that the protein tyrosine phosphatase activity in tumor tissue was increased, suggesting the biological significance of protein tyrosine phosphatase in colon cancer.
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PMID:Elevated protein-tyrosine-phosphatase activity in human colon-carcinoma. 2160 41