Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The expression of serine/threonine kinase (STK) family is frequently altered in human cancers. However, the functions of these kinases in cancer development remain elusive. Here, we report that
STK31
is robustly and heterogeneously expressed in
colon cancer
tissues and plays a critical role in determining the differentiation state of
colon cancer
cells. Knockdown or overexpression of
STK31
induced or inhibited differentiation of
colon cancer
cells, respectively. Deletion of the STK domain abolished the inhibiting effect of
STK31
. Associated with differentiation, knockdown of
STK31
resulted in significant suppression of tumorigenicity both in vitro and in vivo. Genome microarray analysis showed that knockdown of
STK31
altered the expression profile of genes that are known to be involved in germ cell and cancer differentiation. Taken together, these results suggest that
STK31
is able to control the differentiation state of
colon cancer
cells, which critically depends on its STK domain. The present findings may shed light on the new therapeutic approach against cancer by targeting
STK31
and cancer differentiation.
...
PMID:STK31 maintains the undifferentiated state of colon cancer cells. 2282 37
Although large-scale efforts for molecular profiling of cancer samples provide multiple data types for many samples, most approaches for finding candidate cancer genes rely on somatic mutations and DNA copy number only. We present a new method, OncoScape, which exploits five complementary data types across 11 cancer types to identify new candidate cancer genes. We find many rarely mutated genes that are strongly affected by other aberrations. We retrieve the majority of known cancer genes but also new candidates such as
STK31
and MSRA with very high confidence. Several genes show a dual oncogene- and tumor suppressor-like behavior depending on the tumor type. Most notably, the well-known tumor suppressor RB1 shows strong oncogene-like signal in
colon cancer
. We applied OncoScape to cell lines representing ten cancer types, providing the most comprehensive comparison of aberrations in cell lines and tumor samples to date. This revealed that glioblastoma, breast and
colon cancer
show strong similarity between cell lines and tumors, while head and neck squamous cell carcinoma and bladder cancer, exhibit very little similarity between cell lines and tumors. To facilitate exploration of the cancer aberration landscape, we created a web portal enabling interactive analysis of OncoScape results (http://ccb.nki.nl/software/oncoscape).
...
PMID:OncoScape: Exploring the cancer aberration landscape by genomic data fusion. 2732 17
