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Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nontraumatic Clostridium septicum infections may present as either septicemia or as metastatic myonecrosis. Most of these infections occur in debilitated patients with diabetes who are receiving cancer chemotherapy. The majority have a hematologic abnormality or a carcinoma of the colon. Usually there is an ulcerative lesion of the gastrointestinal tract that serves as the portal of entry. While most of these patients die from overwhelming sepsis, our patient was debrided early and treated promptly with high-dose penicillin therapy as well as hyperbaric oxygen therapy. He fully recovered from C. septicum gas gangrene and underwent resection of a recurrent colonic cancer.
Dis Colon Rectum 1983 Nov
PMID:Nontraumatic Clostridium septicum gangrenous myonecrosis. 662 41

The development of identically sited carcinoma of the colon in identical twins is described. A simultaneous presentation occurred. The case is discussed in the context of the cancer family syndrome.
Dis Colon Rectum 1983 May
PMID:Site-specific, simultaneous presentation of colonic carcinoma in identical twins. 668 10

In a case-control study of cholecystectomy and carcinoma of the colon conducted in a residential retirement community near Los Angeles, California, no significant association was found, either for all colonic cancer (relative risk = 1.2) or by subsite (relative risk = 0.8 for right-sided colonic cancer and 1.3 for other colonic cancer). Because of this negative finding and the inconsistency of other epidemiologic studies, certain aspects of the descriptive epidemiology of colonic cancer in Los Angeles were examined to see if they were consistent with a major etiologic role for cholecystectomy. The distribution of right-sided colonic cancer by sex and race contrasted sharply with that expected, based on the known distribution of cholecystectomies in the population. Cholecystectomy is unlikely to be an important factor in the etiology of right-sided colonic cancer.
Dis Colon Rectum 1984 May
PMID:Cholecystectomy and colonic cancer. 671 43

To evaluate the influence of inhibitors of prostaglandin synthesis on the incidence of DMH-induced colon cancer, 90 male Sprague-Dawley rats were randomly assigned to: indomethacin 20 mg per liter drinking water, meclofenamate 50 mg per liter drinking water, or normal drinking water (control group). Dimethylhydrazine was given by weekly subcutaneous injections (20 mg/kg body weight) during the first 20 weeks. Thirty-two weeks after the start of treatment and carcinogen exposure, the animals were killed and examined for the number, size, location, and spread of intestinal tumors. Colon cancer incidence was significantly lower in animals receiving indomethacin (56 per cent) compared with the control group (88 per cent) and with the meclofenamate group (90 per cent) (P less than 0.005). The corresponding figures for tumors in the small intestine were 31, 46, and 35 per cent, respectively. The tumors in indomethacin-treated animals did not differ in number, size, location, or spread from tumors of the other groups, suggesting that indomethacin might influence the carcinogenic process itself, rather than the natural course of the established disease. We conclude that indomethacin significantly reduces the incidence of large-bowel cancer in this animal model and that this observation may have some potential for future chemopreventive studies in human high-risk groups (e.g. ulcerative colitis, familial polyposis).
Dis Colon Rectum 1984 Jun
PMID:Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer. 673 60

During the first 60 years of this century, a seemingly logical and effective operation for carcinoma of the colon was developed. The basic features of the operation are early isolation of the malignancy, wide lymphadenectomy, excision of involved adjacent organs when indicated, and adequate colonic resection. In 1977 a report appeared that purported to show that less radical procedures were equally effective in curing the disease and associated with less morbidity than the more extensive operation. This paper questions the validity of that report and gives other reported data which tend to refute that view. However, all reported series are retrospective and therefore the answer to the question posed in the title is: "We don't really know." A plea is made for a sponsored, randomized, prospective trial to see if a lesser operation will provide the same cure rate.
Dis Colon Rectum
PMID:Is segmental sounder? 708 76

A clinical study to evaluate the Makari Intradermal Test (MIT) involved 180 patients seen with symptoms suggestive of malignant disease, 85 of whom were subsequently shown to have carcinoma of the large bowel, and 66 asymptomatic volunteers. The prognostic value of initial and serial studies relative to patient-survival rate and the efficacy of serial studies in detecting disease in long-term follow-up of patients with resected malignant lesions were evaluated. On the basis of this study, the MIT appears to merit further investigation, not as a definitive diagnostic procedure, but as a survey for identifying patients with early malignancy or individuals at high risk to malignant epigenesis.
Dis Colon Rectum 1981 Apr
PMID:Clinical evaluation of the Makari Intradermal Test in patients with cancer of the colon and rectum. 722 29

Patients with pancolonic chronic ulcerative colitis are at increased risk to develop carcinoma of the colon. Controversy continues, however, as to whether this carcinoma is more "virulent" than "type ordinaire" carcinoma of the colon and as to the best way to manage these patients. This study reviews the characteristics and survival of 70 patients with cancer of the colon superimposed on chronic ulcerative colitis. Patients with carcinoma identified incidentally during prophylactic colectomy for chronic ulcerative colitis fared well (5-year survival of 72 per cent), while those with clinical symptoms or radiographic suggestion of cancer had a poor survival rate (5-year survival of 35 per cent). Patients with panproctocolitis, 10 years of disease, and early onset of disease are most likely to have cancer superimposed on chronic ulcerative colitis. This cancer is likely to have a poorer prognosis than type ordinaire cancer of the colon. Prophylactic proctocolectomy should be considered before evidence suggesting carcinoma develops.
Dis Colon Rectum 1980 Apr
PMID:Carcinoma of the colon and rectum complicating chronic ulcerative colitis. 737 68

It is widely accepted that carcinoma of the large bowel is common in the Western world because we eat a low-residue diet which causes fecal stasis. The part of the large bowel with the most stasis is the appendix, which has similar mucosa; but the incidence of carcinoma per unit area of appendicular mucosa is four times less than carcinoma per unit area of large bowel. Therefore, fecal stasis is probably not important in the etiology of carcinoma of the appendix.
Dis Colon Rectum 1980 Sep
PMID:Carcinoma of colon and appendix related to fecal stasis. 741 78

The role of surgery in the management of intra-abdominal recurrence of colon cancer has not been clearly determined. We reviewed the charts of 28 patients operated upon at our institution for nonhepatic intra-abdominal recurrence of carcinoma of the colon and followed for a median of 10.5 months after reoperation. Total resection of gross disease was possible in 15 patients, who had a median overall actuarial survival of 25.5 months and a disease-free survival of 13 months. Within this group, disease-free survival was significantly prolonged when time to first recurrence was greater than 16 months and when patients had not had a prior operation for recurrent disease (P < 0.05). Six patients having a partial resection and seven patients having only a bypass or ostomy had significantly shorter survivals than those in the totally resected group, with median survivals of 8 and 3.5 months, respectively (P < 0.05). Operative management of recurrent colon cancer may prolong survival when disease can be eradicated, and palliative operations appear more successful when tumor is resected rather than bypassed.
Dis Colon Rectum 1993 Jun
PMID:Surgical management of nonhepatic intra-abdominal recurrence of carcinoma of the colon. 768 66

Surgery has become progressively more reliant on technology. The technique of colonic anastomosis utilizing the biofragmentable anastomotic ring (BAR) is one such example. The benefits of therapeutic laparoscopy have been applied to the arena of colorectal surgery. A case is presented that combines these two modalities in a patient with colon cancer, laparoscopic mobilization of the large bowel, exteriorized resection, and BAR anastomosis.
Dis Colon Rectum 1993 Jun
PMID:Laparoscopic endocorporeal mobilization followed by extracorporeal sutureless anastomosis for the treatment of carcinoma of the left colon. 820 Feb 45


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