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Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The more common patterns of dissemination and recurrence of colonic cancer are known and well-documented. In contrast, extravisceral, distant soft tissue metastases are comparatively rare. Therefore, these metastases are not subject to meaningful generalizations, with the exception that they are often associated with widespread metastatic disease. This report describes the first case of carcinoma of the colon metastatic to the skeletal muscle of the contralateral buttock and the sciatic nerve without concurrent evidence of pelvic or distant metastases. Curative resection was not possible because of involvement of the proximal sciatic nerve.
Dis Colon Rectum 1985 Feb
PMID:Isolated metachronous metastases to soft tissues of the buttock from a colonic adenocarcinoma. 397 5

Three cases of adenocarcinoma of the appendix are reported. All three patients presented with acute appendicitis and the tumors were diagnosed only on histologic examination of the excised appendix. The first patient subsequently had a right hemicolectomy and was proven to have a Dukes' B tumor. The second patient probably had a Dukes' B also, but no further surgery was performed because of advanced presenile dementia. Advanced disease was found in the third patient. Analysis of 145 cases reported over the last ten years suggests that, unless the tumor is in Dukes' A stage, right hemicolectomy should be carried out if the patient is fit for radical surgery. The overall prognosis appears to be the same as that for carcinoma of the colon.
Dis Colon Rectum 1985 Jun
PMID:Adenocarcinoma of the appendix. 400 40

The generally held belief that early diagnosis and treatment are associated with a greater proportion of localized tumors and better prospects of salvage is not supported in carcinoma of the large intestine. This study is not to be interpreted to mean that purposefully delayed treatment in an individual patient will improve his chances of survival. Its purpose is to place the emphasis on early diagnosis in its proper perspective. Entirely different methods of diagnosis need to be developed so as to be able to diagnose carcinoma of the large intestine during its presymptomatic phase.
Dis Colon Rectum 1985 Aug
PMID:Relationship of symptom duration and survival in patients with carcinoma of the colon and rectum. 401 22

A new colon cancer antigen is reported. It is designated as COTA, Colon-Ovarian Tumor Antigen, because it is found in mucins produced by both tissues during malignancy. The new antigen was identified by making antibodies against human colon cancer tissue in goats. The antisera were exhaustively absorbed with lyophilized extracts of normal colon, lung, liver, spleen, kidney, plasma, and the well-known colon tumor antigen, carcinoembryonic antigen (CEA). The new antigen was identified by immunodiffusion. Studies of 28 malignant tissue extracts, 10 ovarian adenocarcinoma cyst fluids, 43 normal tissues, and 5 plasma samples revealed that this antigen is found only in colon tumors and mucinous ovarian adenocarcinomas. The antigen was not detected in serous adenocarcinoma of the ovaries, extracts of adenocarcinoma of lung, breast, kidney or stomach nor in the extracts of normal tissues. Other tests show that this antigen is not CEA, Ca 19-9, or CSAp. It is stable to heating at 65 degrees for 5 minutes; it elutes from an ion exchange matrix (DEAE) with 0.3-0.5M NaCl; it migrates to the alpha-2 region on immunoelectrophoresis; and its size, by exclusion chromatography on Sepharose 4B, is 3-15 million daltons. Anti-COTA stains colon cancer tissue sections indicating that COTA is present in goblet-cell mucin.
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PMID:Characterization of a common antigen of colorectal and mucinous ovarian tumors, COTA. 644 55

The mechanism by which dietary cholesterol facilities colon carcinogenesis was investigated in the dimethylhydrazine-induced rat colon cancer model. Fifty female Wistar rats received a standard course of dimethylhydrazine (DMH) injections (40 mg/kg/week subcutaneously for ten weeks) while being fed Vivonex, a cholesterol-free elemental diet. Animals were allocated to one of five dietary regimens. One control group received Vivonex with added cholesterol (10 mg/100 ml Vivonex/rat/day) throughout the experiment, while another group received Vivonex alone. The remaining three groups received added cholesterol exclusively before, during or after the ten week DMH induction period. The experiment continued for over 500 days, and was evaluated by comparing, between groups, the time taken for the development of objective signs of colonic disease (time to tumour presentation or TTP). Animals either died spontaneously or were killed and autopsied. Colon cancers were confirmed histologically in every animal. The results showed that cholesterol feeding throughout the experiment or during the DMH induction period reduced the TTP compared to controls (p less than 0.05). Cholesterol prefeeding had no such effect. In the after group, the TTP was correspondingly delayed (p less than 0.05). Cholesterol-fed controls and groups receiving cholesterol during or after the DMH induction had more colon tumours and/or a greater incidence of metastases than cholesterol-free controls or those pre-fed cholesterol. The findings indicate a direct relationship between timing of cholesterol exposure and signs of colon cancer, and demonstrate that dietary cholesterol has promoter-like characteristics.
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PMID:An investigation into the mechanism of co-carcinogenesis of dietary cholesterol during the induction of colon cancer in rats by 1,2 dimethylhydrazine. 647 81

Nontraumatic Clostridium septicum infections may present as either septicemia or as metastatic myonecrosis. Most of these infections occur in debilitated patients with diabetes who are receiving cancer chemotherapy. The majority have a hematologic abnormality or a carcinoma of the colon. Usually there is an ulcerative lesion of the gastrointestinal tract that serves as the portal of entry. While most of these patients die from overwhelming sepsis, our patient was debrided early and treated promptly with high-dose penicillin therapy as well as hyperbaric oxygen therapy. He fully recovered from C. septicum gas gangrene and underwent resection of a recurrent colonic cancer.
Dis Colon Rectum 1983 Nov
PMID:Nontraumatic Clostridium septicum gangrenous myonecrosis. 662 41

The development of identically sited carcinoma of the colon in identical twins is described. A simultaneous presentation occurred. The case is discussed in the context of the cancer family syndrome.
Dis Colon Rectum 1983 May
PMID:Site-specific, simultaneous presentation of colonic carcinoma in identical twins. 668 10

In a case-control study of cholecystectomy and carcinoma of the colon conducted in a residential retirement community near Los Angeles, California, no significant association was found, either for all colonic cancer (relative risk = 1.2) or by subsite (relative risk = 0.8 for right-sided colonic cancer and 1.3 for other colonic cancer). Because of this negative finding and the inconsistency of other epidemiologic studies, certain aspects of the descriptive epidemiology of colonic cancer in Los Angeles were examined to see if they were consistent with a major etiologic role for cholecystectomy. The distribution of right-sided colonic cancer by sex and race contrasted sharply with that expected, based on the known distribution of cholecystectomies in the population. Cholecystectomy is unlikely to be an important factor in the etiology of right-sided colonic cancer.
Dis Colon Rectum 1984 May
PMID:Cholecystectomy and colonic cancer. 671 43

To evaluate the influence of inhibitors of prostaglandin synthesis on the incidence of DMH-induced colon cancer, 90 male Sprague-Dawley rats were randomly assigned to: indomethacin 20 mg per liter drinking water, meclofenamate 50 mg per liter drinking water, or normal drinking water (control group). Dimethylhydrazine was given by weekly subcutaneous injections (20 mg/kg body weight) during the first 20 weeks. Thirty-two weeks after the start of treatment and carcinogen exposure, the animals were killed and examined for the number, size, location, and spread of intestinal tumors. Colon cancer incidence was significantly lower in animals receiving indomethacin (56 per cent) compared with the control group (88 per cent) and with the meclofenamate group (90 per cent) (P less than 0.005). The corresponding figures for tumors in the small intestine were 31, 46, and 35 per cent, respectively. The tumors in indomethacin-treated animals did not differ in number, size, location, or spread from tumors of the other groups, suggesting that indomethacin might influence the carcinogenic process itself, rather than the natural course of the established disease. We conclude that indomethacin significantly reduces the incidence of large-bowel cancer in this animal model and that this observation may have some potential for future chemopreventive studies in human high-risk groups (e.g. ulcerative colitis, familial polyposis).
Dis Colon Rectum 1984 Jun
PMID:Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer. 673 60

During the first 60 years of this century, a seemingly logical and effective operation for carcinoma of the colon was developed. The basic features of the operation are early isolation of the malignancy, wide lymphadenectomy, excision of involved adjacent organs when indicated, and adequate colonic resection. In 1977 a report appeared that purported to show that less radical procedures were equally effective in curing the disease and associated with less morbidity than the more extensive operation. This paper questions the validity of that report and gives other reported data which tend to refute that view. However, all reported series are retrospective and therefore the answer to the question posed in the title is: "We don't really know." A plea is made for a sponsored, randomized, prospective trial to see if a lesser operation will provide the same cure rate.
Dis Colon Rectum
PMID:Is segmental sounder? 708 76


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