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Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present a retrospective study on 610 patients with colorectal cancer diagnosed over a 10 year period; 21 patients (3.4%) had synchronous multiple primary carcinomas. Age and clinical symptoms were similar to those with single carcinomas. In 57% of patients, the presence of synchronous neoplasms was diagnosed preoperatively by colonoscopy and/or barium enema, in 38% peroperatively and in 5% postoperatively. The more frequent localizations were rectum-sigmoid colon (24%) and descendent colon-sigmoid colon (19%). Three patients had 3 synchronous tumors, respectively. According to the Dukes classification, 80% of the patients had stage B or C. The five-year survival rate was 61%, similar to that for colon cancer in general. We emphasize the importance of preoperative identification of synchronous lesions; the whole colon should be investigated before surgery in order to ensure that no synchronous tumor has been missed or to change planned surgery.
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PMID:[Synchronous carcinoma of the colon and the rectum (21 cases)]. 163 13

A 71-year-old female patient underwent urgent laparotomy due to severe right lower quadrant abdominal pain and fever. Macroscopically duplex coecal and transverse colon cancer as well as a sigmoid or left ovarian cancer were suspected. Pathological findings revealed synchronous left ovarian and transverse colonic neoplasms. Both primaries metastatized to their regional lymph nodes. Furthermore, the ovarian cancer infiltrating the sigmoid colon gave distant metastasis in the coecum, too. Ovarian cancer histology showed papillary adenocarcinoma, and transverse colon cancer was a tubular adenocarcinoma. The affected lymph nodes were clearly distinguished by immunohistochemistry staining: ovarian metastases were CK7 positive, and colonic metastases were CK20 and CEA positive. The patient was treated with combinated chemotherapy: FOLFOX-4 two weekly and paclitaxel monotherapy every other week. The patient tolerated this combined treatment well. The authors conclude that multiple synchronous neoplasms can be treated with individualized chemotherapeutic protocol with good efficacy and few adverse reactions.
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PMID:[Individualized therapy of synchronous ovarian and colon cancers with lymph]. 2602 2