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Query: UMLS:C0699790 (colon cancer)
 28,837 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cancers of the buccal cavity and the pharynx are not only anatomically related but, except for the nasopharynx, also have risk factors in common. Multifocal occurrence of cancers in the buccal cavity and pharynx must be kept in mind when one is interpreting findings on multiple tumors. However, susceptibility to common risk factors, predominantly alcohol and tobacco, seem to be in operation among males, inasmuch as excess lung cancer followed cancers of the tongue [relative risk (RR) = 2.2], other parts of the mouth (RR = 2.2), and pharynx (RR = 2.0). Among females, lung cancer was in excess after cancers of the tongue (RR = 3.7) and mouth (RR = 3.6). Among males, esophageal cancer was elevated after cancers of the mouth (RR = 4.7) and tongue (RR = 5.7). Other combinations of tobacco-related cancers among males include those of the bladder (RR = 2.5) after cancer of the tongue and larynx (RR = 5.4) after pharyngeal cancer. Common etiologic factors or the multifocal nature of tumors of the buccal cavity might also account for the increases of cancer of the mouth (RR = 2.6) following lip cancer and cancer of the tongue (RR = 14) following mouth cancers among males. Among females, cancer of the mouth (RR = 17) was elevated after tongue, tongue (RR = 31) after mouth, and tongue (RR = 10) after salivary gland tumors. The excess of pharyngeal cancers in women (RR = 19) following cancer of the lip may be explained by common risk factors. Observed deficits of colon cancer following cancer of the lip in males and after tongue and salivary gland tumors in females could reflect low socioeconomic status, although a deficit of stomach cancer among males (RR = 0.1) also followed cancer of the salivary glands.
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PMID:Second cancer following cancers of the buccal cavity and pharynx in Denmark, 1943-80. 408 2

The risk of developing a second primary cancer was evaluated in approximately 64,000 persons diagnosed with cancer of the digestive system in Connecticut during 1935-82. Significant excesses of all second cancers combined were observed following cancer of the esophagus (58 observed vs. 33 expected), small intestine (41 vs. 24), and colon (2,268 vs. 1,714). A slight excess of multiple primaries was observed following cancer of the liver and biliary tract (47 vs. 40). The observed number of second cancers was nearly equal to the expected number for persons initially diagnosed with cancers of the stomach (251 vs. 258), rectum (952 vs. 941), and pancreas (40 vs. 40). Persons with initial cancers of the small intestine, colon, and rectum also had excess second cancers arising primarily in the colon, which suggested the influence of common etiologic factors or possibly misclassified metastases in some. Shared dietary, socioeconomic, or hormonal factors may explain the excess of uterine and ovarian cancers among patients with colon cancer and the excess of breast cancer among patients with colon and rectal cancers. Oral and respiratory cancers occurred more frequently than expected in persons with an initial esophageal cancer, which is likely due to common risk factors of cigarette smoking or alcohol intake, or both. The elevations in cancer of the prostate among males with cancers of the esophagus, small intestine, colon, rectum, liver/biliary, and pancreas are probably artifacts associated with increased medical surveillance of cancer patients. The prostate cancer excesses were limited to the first year after diagnosis of the initial cancer or decreased over time for all but cancer of the colon and small intestines. Increased medical surveillance may also contribute to the excess renal and bladder cancers seen within 5 years of diagnosis of stomach cancer. Excesses were also seen for second pancreatic cancer among small intestine and liver/biliary cancer patients and second kidney and brain cancers among those with colon cancer. The deficits of stomach and rectal cancer among persons initially diagnosed with the same tumors, respectively, were anticipated because surgical removal of the organ is the primary form of treatment. Patients with rectal cancer also had deficits of stomach and pancreatic cancers. Future research should clarify the role of diet, alcohol, metabolic and endocrine factors, and host susceptibility on the risk of second neoplasms following cancer of the digestive system.
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PMID:Second cancer following cancer of the digestive system in Connecticut, 1935-82. 408 13

The risk of a person developing a second primary cancer was evaluated in approximately 30,000 persons who developed cancer of the respiratory system in Connecticut between 1935 and 1982. A significant 44% excess of all second cancers was observed following cancer of the lung (614 observed vs. 426 expected). The excess of second tumors was 72% following cancer of the larynx (541 vs. 314) and 34% following cancer of the nasal cavities and sinuses (43 vs. 32). For cancers of the lung and larynx, second cancers arose mainly along the respiratory tract or other sites associated with cigarette smoking (oral cavity, bladder, kidney). A threefold excess of esophageal cancer followed cancer of the larynx, which was indicative of risk factors in common (alcohol and tobacco) and possibly an effect of radiotherapy. Radiotherapy may have contributed also to the increased risk of second lung and breast cancers. A slight excess risk of leukemia after lung cancer points to a possible effect of chemotherapy given for certain histologic types. An unexpected finding was a significant 50% increased risk of colon cancer following cancer of the larynx. Significant excesses of prostate cancer are probably artifacts associated with increased medical surveillance and higher autopsy rates among cancer patients than in the general population. No deficits of any second cancers were observed. The risk of a second cancer developing did not appear to vary by sex or time since initial diagnosis, except that the risks following cancer of the nasal cavities and sinuses returned to normal levels among long-term survivors. Among persons observed for 10 or more years after their initial diagnosis of cancers of the lung or larynx, the risk of developing a second cancer remained high, i.e., on the order of 50% above expectation. Further analytic studies should clarify the role of smoking, alcohol, other life-style and host factors, and various forms of therapy on the risk of second cancers following cancer of the respiratory system.
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PMID:Second cancer following cancer of the respiratory system in Connecticut, 1935-1982. 408 14

Serum tissue polypeptide antigen (TPA) levels were measured in 33 patients with esophageal cancer, 39 with stomach cancer and 50 with colon cancer. At the same time five glycoproteins, namely immunosuppressive acidic glycoprotein (IAP), alpha 1-antichymotripsin (alpha 1-ACT), acid soluble glycoproteins (ASP), sialic acid and carcinoembryonic antigen (CEA), were measured for comparison. The mean TPA values were 59.0 +/- 15.4 U/l in 61 normal subjects, 103.6 +/- 104.2 U/l (positive rate, 24.2%) in esophageal cancer patients, 111.9 +/- 49.8 U/l (71.8%) in stomach cancer patients and 124.8 +/- 195.5 U/l (40%) in colon cancer patients. The serum TPA levels in patients with stomach cancer rose with an increased number of involved lymph nodes and with a higher degree of infiltrative growth and increased with the advancement of tumor growth postoperatively. Serum TPA levels correlated well with those of alpha 1-ACT, IAP and ASP in stomach cancer patients and with those of CEA, ASP and sialic acid in colon cancer, but not in esophageal cancer patients. It is suggested that the serum TPA might represent one of the reactant proteins and/or tumor-associated antigens that appear to be dependent upon the cancer status.
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PMID:[Clinical evaluation of tissue polypeptide antigen in patients with esophageal, stomach and colon cancer]. 648 66

Four hundred and eight cases with multiple primary malignant neoplasms from 5,456 autopsy cases were reviewed, and their age, sex, sites and relationship between the two cancers were analysed. Expected number of the second cancer was calculated based upon the person-years of 8,444 cases with primary gastro-intestinal cancers. Significant higher incidence was observed in the oropharyngeal cancer, esophageal cancer in male, and colon cancer in female. Organ relationship was present along the gastrointestinal tract, as observed in autopsy cases. Biological meaning of multiple primary malignant neoplasms was discussed.
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PMID:[Multiple primary malignant neoplasms in the national cancer center during 1962-1981]. 651

The relationships between areal differences in mortality from six digestive-tract cancers and consumption of selected foods in 46 of the 47 Japanese prefectures (Okinawa being excluded) were analyzed. Statistical analyses disclosed that the groups of foods positively associated with cancer death were as follows: for esophageal cancer, pork, oil, popular-grade sake, and green tea; for stomach cancer, fresh fish, salted or dried fish, salt, and special-grade sake; for colon cancer, bread, milk, butter, margarine, ketchup, beer, and salted or dried fish; for rectal cancer, fresh fish, salted or dried fish, salt, and popular-grade sake; for cancer of the biliary passages, pork, popular-grade sake, and green tea; and for pancreatic cancer, oil, mayonnaise, fresh fish, and salted or dried fish. These results are based on statistical analyses. Further epidemiological analyses are required to find a biological causal relationship.
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PMID:Statistical analyses on the pattern of food consumption and digestive-tract cancers in Japan. 654 78

Sera from 111 patients with various gastro-intestinal (GI) diseases were studies for the presence of antibodies to human serum albumin (HSA), bovine serum albumin (BSA) and ovalbumin (OA) by passive haemagglutination assay. The antibody titre to BSA was higher than that to HSA or OA. The anti-BSA antibody was demonstrated in upper GI diseases i.e. esophageal cancer, gastric ulcer, gastric cancer and duodenal ulcer, and not in lower GI disease i.e. Crohn's disease, ulcerative colitis and colon cancer. Both the mean titre and the incidence of the anti-BSA antibody tended to be higher in women than in men, and the titre was in a positive correlation with serum gamma-globulin levels. Sephadex G-200 column chromatography revealed that the anti-BSA antibody was widely distributed between void volume and 7S fraction.
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PMID:Anti-albumin antibodies in sera of patients with gastro-intestinal disease. 714 Nov 96

A good coverage by the Hong Kong Cancer Registry of cases of the common cancers diagnosed in Hong Kong during 1974-78 is indicated by an excess of cases over deaths registered, which is according to expectation from survival prospects. The trends during 1961-79 showed a rapid increase in mortality from lung cancer in both sexes, a moderate rise in liver cancer in males, and small increases in esophageal cancer in males and colon cancer in females. Cervical cancer was the only neoplasm that showed a decreasing trend, although this was small in proportion. Some epidemiological observations on cancer arising in the lung, liver, larynx, and nasopharynx are presented.
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PMID:Cancer in Hong Kong: some epidemiological observations. 716 94

In Yugoslavia, esophageal cancer is the fourth most frequent malignant disease of the gastrointestinal tract, after stomach cancer, rectum, and colon cancer. Incidence of esophageal cancer in Croatia in 1975 was 6.0 per 100,000 population for males, and considerably less for females with 1.4 per 100,000 population. There is not a statistically significant difference in the incidence of esophageal cancer in the different regions within Croatia. During the period from March 1973 to April 1980 at the Central Institute for Tumors and Allied Diseases in Zagreb, esophagoscopy was performed on 179 patients with esophageal tumors. Test results of 170 patients was 60.4 years (male 60.0, female 62.4). The authors present the analyses of histopathologic types of tumors. In 79.4% of patients (135/170) squamous cell carcinoma was found. In 69 patients histologic findings were compared with cytology. In six patients, only the cytological examinations were positive. Furthermore, the localizations of tumors in the esophagus were analyzed, and in 53.6% of patients (91/170) tumor was localized in the middle third of the esophagus. In almost all cases the disease was advanced and inoperable. Smoking and alcoholism were analyzed as potential etiological factors. The authors consider that esophagoscopy could be a valuable method in the early detection of esophageal carcinoma in the high risk group of the population (men over 50 years of age who are heavy alcoholics and smokers).
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PMID:Esophageal tumors--the role of esophagoscopy. 734 97

Gastrointestinal bleeding is believed to cause iron-deficiency anemia (IDA). The information concerning ideal evaluation of the gastrointestinal tract and exact findings in patients with IDA is scant. The aim of this study was to prospectively evaluate patients with IDA for gastrointestinal lesions potentially causing IDA at a US Army Teaching Medical Center with Gastroenterology Fellowship. Seventy patients with IDA had esophagogastroduodenoscopy (EGD) and colonoscopy, and if this evaluation was unremarkable, then small bowel biopsy was obtained at EGD to evaluate for celiac disease. Enteroclysis was done if endoscopic evaluation was negative. At endoscopy, at least one lesion potentially accounted for the IDA in 50 (71%) patients. At colonoscopy, 21 (30%) patients had 22 lesions (four colon cancer, seven adenoma > 1 cm, six vascular malformation, four severely bleeding hemorrhoids, one ileal Crohn's); at EGD, 39 (56%) patients had 43 lesions (11 gastric erosion, 10 esophagitis, four vascular malformation, four celiac disease, three gastric cancer, three gastric ulcer, three duodenal ulcer, two gastric polyp > 1 cm, one duodenal lymphoma, one esophageal cancer, and one duodenal Crohn's). Twelve (17%) patients had both upper and lower gastrointestinal tract lesions. Twenty-four of 32 (75%) patients with positive fecal occult blood test had potentially bleeding lesions compared to 24 of 38 (63%) patients with negative fecal occult blood test (P > 0.05). Six of nine patients with malignancy had positive fecal occult blood test. Twenty patients with normal endoscopy and small bowel biopsy had normal enteroclysis.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Prospective evaluation of gastrointestinal tract in patients with iron-deficiency anemia. 778 48


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